Editorial Material
Cell Biology
David Corujo, Marcus Buschbeck
Summary: The interaction between non-immune and immune cells in the tumor microenvironment plays a crucial role in the immune attack on cancer cells. A recent study on melanoma cells reveals that specific histone variants can suppress the expression of cytokine genes in cancer-associated fibroblasts, resulting in an immunosuppressive tumor microenvironment.
NATURE CELL BIOLOGY
(2023)
Article
Immunology
Mateus da Silva Matias Antunes, Fabricia Heloisa Cavicchioli Sugiyama, Humberto Doriguetto Gravina, Ricardo Cardoso Castro, Francisco Javier Romero Mercado, Julia Oliveira de Lima, Caroline Fontanari, Fabiani Gai Frantz
Summary: This study aimed to investigate the immunophenotyping, cytokine, and metabolic profile of monocytes from individuals who were vaccinated with inactivated COVID-19 vaccine or non-replicating viral vector vaccine. The results showed that vaccination reduced the inflammatory response of monocytes to unrelated stimuli, indicating the induction of trained immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Michael Karin, Shabnam Shalapour
Summary: Chronic inflammation promotes tumor development and treatment resistance, while the antagonism between inflammation and immunity, as well as cancer cells' ability to evade immune detection, affect cancer development and treatment outcomes.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Cell Biology
Arailym Aronova, Federica Tosato, Nawraa Naser, Yaw Asare
Summary: Innate immune pathways play a crucial role in the development of atherosclerosis and targeting these pathways may effectively reduce the risk of cardiovascular disease. Understanding the interplay between these pathways and the long-term reprogramming of immune cells is essential for the development of targeted therapeutic interventions.
Article
Medicine, General & Internal
Roberta Romano, Francesca Cillo, Cristina Moracas, Laura Pignata, Chiara Nannola, Elisabetta Toriello, Antonio De Rosa, Emilia Cirillo, Emma Coppola, Giuliana Giardino, Nicola Brunetti-Pierri, Andrea Riccio, Claudio Pignata
Summary: The epigenome plays a crucial role in fine-tuning gene transcription by bridging environmental factors and the genome. It involves various intricate changes, such as DNA methylation, chromatin remodeling, histone modifications, and RNA processing, which regulate physiological processes in development, maturation, and maintenance of cellular identity and function. Recent studies on genome-wide DNA methylation data have shed new light on the potential contribution of epigenetics in the pathophysiology of the immune system and host defense. Understanding environment-genome interactions through the study of patients with mutations in genes encoding for epigenetic machinery has provided insights and potential therapeutic options.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Maojun You, Yanan Gao, Junliang Fu, Runze Xie, Zhenyu Zhu, Zhixian Hong, Lingzhan Meng, Shunda Du, Junliang Liu, Fu-Sheng Wang, Pengyuan Yang, Liang Chen
Summary: This study investigates the epigenomic programs that regulate the differentiation and generation of HBV-related T cells in response to viral infection and HBV + HCC unique immune exhaustion. The study also highlights the correlation between HBV-related tumor-infiltrating regulatory T cells and increased viral titer and poor prognosis in patients.
Article
Biochemistry & Molecular Biology
Sushmita Seni, Roshan Kumar Singh, Manoj Prasad
Summary: Plants control gene expression by manipulating chromatin structure and histone modifications, in which SDGs play a crucial role. SDGs affect chromatin structure and protein-protein interactions, and also impact alternative splicing events.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Review
Cell Biology
Martin Montecino, Margarita E. Carrasco, Gino Nardocci
Summary: Genomic DNA in the eukaryotic nucleus is organized into chromatin through stable interactions with histone proteins and other nuclear components, contributing to differential control of access to key genetic information. Epigenetic mechanisms, such as DNA methylation and chromatin remodeling, play critical roles in regulating gene expression by modifying chromatin compaction levels for transcription activation and repression. The review discusses evidence supporting the role of these mechanisms in the transcriptional control of osteoblast-related genes, particularly at the Runx2 and Sp7 genes, which encode master regulators of osteogenic lineage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Huizhe Wang, Xiaohui Xiong, Jiaqi Zhang, Meicen Wu, Yinhui Gu, Yanli Chen, Yueqing Gu, Peng Wang
Summary: This study found that CycNHOH NPs and CypNHOH NPs can activate innate immunity by accelerating the DNA damage process through phototherapy and releasing immunogenic cell death, providing a new direction for the development of photo-immunotherapy.
Article
Oncology
Jinyang Li, Salina Yuan, Robert J. Norgard, Fangxue Yan, Yu H. Sun, Il-Kyu Kim, Allyson J. Merrell, Yogev Sela, Yanqing Jiang, Natarajan Bhanu, Benjamin A. Garcia, Robert H. Vonderheide, Andres Blanco, Ben Z. Stanger
Summary: This study identifies lysine demethylase 3A (KDM3A) as an epigenetic regulator that affects the response to immunotherapy in pancreatic ductal adenocarcinoma by modulating the expression of epidermal growth factor receptor (EGFR) through Krueppel-like factor 5 (KLF5) and SMAD family member 4 (SMAD4). Inhibition of EGFR can reshape the immune microenvironment, offering a potential immunotherapy-sensitizing strategy for PDA.
Article
Biochemistry & Molecular Biology
Adielle Rodrigues da Silva, Delmira da Costa Silva, Kaliane Nascimento dos Santos Pinto, Hermes Peixoto Santos Filho, Mauricio Antonio Coelho Filho, Walter dos Santos Soares Filho, Claudia Fortes Ferreira, Abelmon da Silva Gesteira
Summary: The study explores the relationship between DNA methylation, scion-rootstock interaction, and plant response to Phytophthora infection in citrus plants. Results show that different combinations of scion and rootstock varieties impact DNA methylation patterns and plant resistance to the pathogen, suggesting a potential for enhancing plant defense mechanisms against gummosis caused by Phytophthora in citrus.
Review
Immunology
Hunter Bennett, Ty D. Troutman, Mashito Sakai, Christopher K. Glass
Summary: Kupffer cells are the resident macrophages of the liver, playing important roles in responses to tissue damage and specialized activities such as iron scavenging. Recent studies have focused on the epigenetic pathways that establish Kupffer cell identity and function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Andrew W. Daman, Steven Z. Josefowicz
Summary: Interferons play a crucial role in inhibiting viral replication and are associated with autoimmune diseases and infections. Researchers have focused on the transcriptional regulation of interferons, particularly emphasizing the assembly and function of factors that regulate IFN-beta enhancer activity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Cell Biology
Feng-Ming Tien, Hsuan-Hsuan Lu, Shu-Yung Lin, Hsing-Chen Tsai
Summary: The tumor immune microenvironment is a complex system where immune cell subtypes interact with cancer cells and stromal cells. The composition and characteristics of the immune landscape during cancer development greatly impact the effectiveness of systemic antitumor therapy in patients. Epigenetic mechanisms play a key role in antitumor immunity and immune state transitions. Targeting epigenetic modifiers to reshape the immune microenvironment has the potential to improve cancer immunotherapy and overcome therapeutic challenges.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Correction
Multidisciplinary Sciences
Shane J. F. Cronin, Corey Seehus, Adelheid Weidinger, Sebastien Talbot, Sonja Reissig, Markus Seifert, Yann Pierson, Eileen McNeill, Maria Serena Longhi, Bruna Lenfers Turnes, Taras Kreslavsky, Melanie Kogler, David Hoffmann, Melita Ticevic, Debora da Luz Scheffer, Luigi Tortola, Domagoj Cikes, Alexander Jais, Manu Rangachari, Shuan Rao, Magdalena Paolino, Maria Novatchkova, Martin Aichinger, Lee Barrett, Alban Latremoliere, Gerald Wirnsberger, Guenther Lametschwandtner, Meinrad Busslinger, Stephen Zicha, Alexandra Latini, Simon C. Robson, Ari Waisman, Nick Andrews, Michael Costigan, Keith M. Channon, Guenter Weiss, Andrey V. Kozlov, Mark Tebbe, Kai Johnsson, Clifford J. Woolf, Josef M. Penninger
Article
Biochemistry & Molecular Biology
Rene Rauschmeier, Charlotte Gustafsson, Annika Reinhardt, Noelia A-Gonzalez, Luigi Tortola, Dilay Cansever, Sethuraman Subramanian, Reshma Taneja, Moritz J. Rossner, Michael H. Sieweke, Melanie Greter, Robert Mansson, Meinrad Busslinger, Taras Kreslavsky
Article
Immunology
Grace J. Liu, Markus Jaritz, Miriam Wohner, Benedikt Agerer, Andreas Bergthaler, Stephen G. Malin, Meinrad Busslinger
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Louisa Hill, Anja Ebert, Markus Jaritz, Gordana Wutz, Kota Nagasaka, Hiromi Tagoh, Daniela Kostanova-Poliakova, Karina Schindler, Qiong Sun, Peter Boenelt, Maria Fischer, Jan-Michael Peters, Meinrad Busslinger
Article
Immunology
Astrid Hagelkruys, Gerald Wirnsberger, Johannes Stadlmann, Miriam Wohner, Marion Horrer, Bojan Vilagos, Gustav Jonsson, Melanie Kogler, Luigi Tortola, Maria Novatchkova, Peter Bonelt, David Hoffmann, Rubina Koglgruber, Ulrike Steffen, Georg Schett, Meinrad Busslinger, Andreas Bergthaler, Christoph Klein, Josef M. Penninger
Summary: Loss of Jagn1 leads to alterations in ER and reduced antibody production in B cells, resulting in compromised humoral immune response in mice.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Tinhinane Fali, Tegest Aychek, Maroua Ferhat, Jean-Yves Jouzeau, Meinrad Busslinger, David Moulin, Gerard Eberl
MUCOSAL IMMUNOLOGY
(2020)
Article
Immunology
Vassilis Glaros, Rene Rauschmeier, Artem Artemov, Annika Reinhardt, Sebastian Ols, Aikaterini Emmanouilidi, Charlotte Gustafsson, Yuanyuan You, Claudio Mirabello, Asa K. Bjorklund, Laurent Perez, Neil P. King, Robert Mansson, Davide Angeletti, Karin Lore, Igor Adameyko, Meinrad Busslinger, Taras Kreslavsky
Summary: Cell fate decisions during early B cell activation dictate the immune response to pathogens and vaccines. The study found that a homogeneous population of activated precursors gives rise to plasmablasts and germinal center B cells after antigen exposure, with most precursors quickly exiting the cell cycle to form early memory B cells. The decline in antigen availability controls these events, demonstrating the plasticity of the immune response.
Article
Multidisciplinary Sciences
Ramesh Yelagandula, Aleksandr Bykov, Alexander Vogt, Robert Heinen, Ezgi Oezkan, Marcus Martin Strobl, Juliane Christina Baar, Kristina Uzunova, Bence Hajdusits, Darja Kordic, Erna Suljic, Amina Kurtovic-Kozaric, Sebija Izetbegovic, Justine Schaeffer, Peter Hufnagl, Alexander Zoufaly, Tamara Seitz, Manuela Foedinger, Franz Allerberger, Alexander Stark, Luisa Cochella, Ulrich Elling
Summary: The SARSeq method presented in this study uses a dual indexing strategy in a multiplexed RT-PCR reaction to diagnose SARS-CoV-2 at scale with high sensitivity and robustness. It can also be used for simultaneous detection of other viruses and expanded to detect other pathogens.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Lesly Calderon, Karina Schindler, Stephen G. Malin, Alexandra Schebesta, Qiong Sun, Tanja Schwickert, Chiara Alberti, Maria Fischer, Markus Jaritz, Hiromi Tagoh, Anja Ebert, Martina Minnich, Adrian Liston, Luisa Cochella, Meinrad Busslinger
Summary: Pax5 plays a crucial role in mature B cells by inhibiting PTEN protein expression, which promotes differentiation and survival of B cells, thereby enhancing humoral immunity.
SCIENCE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sabine Jurado, Anna S. Fedl, Markus Jaritz, Daniela Kostanova-Poliakova, Stephen G. Malin, Charles G. Mullighan, Sabine Strehl, Maria Fischer, Meinrad Busslinger
Summary: PAX5 is an important tumor suppressor gene in B-cell acute lymphoblastic leukemia, but it is also involved in coding for various PAX5 fusion proteins. A study found that the PAX5-JAK2 fusion protein can promote leukemia development in a mouse model.
Article
Immunology
Rene Rauschmeier, Annika Reinhardt, Charlotte Gustafsson, Vassilis Glaros, Artem V. Artemov, Josefine Dunst, Reshma Taneja, Igor Adameyko, Robert Mansson, Meinrad Busslinger, Taras Kreslavsky
Summary: The transcription factor Bhlhe40 plays a crucial negative regulatory role in the germinal center reaction by affecting both B cells and T follicular helper cells intrinsically, leading to a dysregulated germinal center response and potential lymphomagenesis in its absence.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Fabian M. P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A. S. H. Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, Andre Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D. Katsikis, Joyce H. G. Lebbink, Kikue Tachibana, Mirjam van der Burg, Chris De Zeeuw, Aleksandra Badura, Meinrad Busslinger
Summary: This study identifies PAX5 mutations associated with primary antibody deficiencies and autism spectrum disorder (ASD) and reveals their roles in immune and neural development using a patient-specific mouse model. These findings provide new insights into the underlying mechanism of this novel immunological and neurodevelopmental syndrome.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Theresa Pinter, Maria Fischer, Markus Schaefer, Michaela Fellner, Julian Jude, Johannes Zuber, Meinrad Busslinger, Miriam Woehner
Summary: Plasma cells and plasmablasts are crucial for immune protection, and this study identified several new genes that are essential for plasmablast development through CRISPR-Cas9 screening.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Miriam Woehner, Theresa Pinter, Peter Boenelt, Astrid Hagelkruys, Daniela Kostanova-Poliakova, Johannes Stadlmann, Stephen F. Konieczny, Maria Fischer, Markus Jaritz, Meinrad Busslinger
Summary: Plasma cells secrete antibodies to protect against pathogens, and the secretion potential of plasma cells is controlled by the transcription factor Xbp1. Mist1, as the target gene of Xbp1, plays an important role in regulating antibody secretion. Deficiency of Mist1 leads to a decrease in plasma cell number and an increase in antibody production and secretion. Mist1 restrains antibody secretion by regulating the expression of Blimp1.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Louisa Hill, Gordana Wutz, Markus Jaritz, Hiromi Tagoh, Lesly Calderon, Jan-Michael Peters, Anton Goloborodko, Meinrad Busslinger
Summary: By regulating the expression level of Wapl, pro-B cells and pre-B cells use different chromatin folding principles for V gene recombination, leading to allelic exclusion at the Igh locus.
NATURE COMMUNICATIONS
(2023)
