期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 1, 期 5, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a000489
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- Medical Research Council [G0700091B] Funding Source: researchfish
- Wellcome Trust [075398, 084469] Funding Source: Medline
In addition to specifying cell fate, there is a wealth of evidence that molecular gradients are also primarily responsible for specifying cell polarity, particularly in the plane of epithelial sheets (planar polarity). The first compelling evidence of a role for gradients in specifying planar polarity came from transplantation experiments in the insect cuticle. More recent molecular genetic analyses in the fruit fly Drosophila have begun to give insights into the molecular nature of the gradients involved, and how they are interpreted at the cellular level.
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