期刊
JOURNAL OF MOLECULAR CELL BIOLOGY
卷 1, 期 2, 页码 66-68出版社
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjp016
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T helper (Th) 17 cells are a recently identified subset of T cells that regulate tissue inflammation, and ROR gamma t and ROR alpha have been shown to be Th17-specific transcription factors that mediate Th17 cell generation. A new study of Batf-deficient mice shows that this AP-1 family transcription factor also regulates Th17 cell differentiation by binding to Th17-associated gene promoters and by maintaining ROR alpha and ROR gamma t expression, shedding new lights on current clinical modulation of Th17 cell function in inflammatory diseases.
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