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Medicine, General & Internal
Wan-Hsiang Hu, Wen-Chi Yang, Pei-Feng Liu, Ting-Ting Liu, Paul Morgan, Wei-Lun Tsai, Hung-Wei Pan, Cheng-Hsin Lee, Chih-Wen Shu
Summary: Gene mutation and pathogenesis bacteria are highly associated with colorectal cancer (CRC) development and progression. Autophagy, especially the key component ATG5, plays a crucial role in CRC malignancy with implications for both overall and disease-free survival. Further studies on ATG5 may provide insights into its potential as a prognostic biomarker and therapeutic target for CRC patients.
Review
Oncology
Cristina Pizzimenti, Vincenzo Fiorentino, Mariausilia Franchina, Maurizio Martini, Giuseppe Giuffre, Maria Lentini, Nicola Silvestris, Martina Di Pietro, Guido Fadda, Giovanni Tuccari, Antonio Ieni
Summary: The present review discusses the cellular process of autophagy, which plays a dual role as both a tumour promoter and a tumour suppressor. Molecular mechanisms and regulatory pathways of autophagy are analyzed, with a particular focus on human astrocytic neoplasms. Additionally, the relationships between autophagy, the tumour immune microenvironment, and glioma stem cells are explored. The development of autophagy-targeting drugs is also discussed, which could potentially improve the treatment of therapy-resistant patients.
Article
Medicine, General & Internal
Hosub Park, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Seongsik Bang, Byung Kyu Ahn, Jaekyung Myung, Seungsam Paik, Hyunsung Kim
Summary: This study evaluated the clinicopathological significance and prognostic value of MTUS1 in colorectal adenocarcinoma. The results showed that low MTUS1 protein expression is associated with adverse clinicopathological characteristics and poor survival outcomes in patients with colorectal adenocarcinoma. These results suggest that MTUS1 functions as a tumor suppressor in colorectal adenocarcinoma and could be a potential prognostic biomarker.
Article
Cell Biology
Zi-Hao Wang, Yu Li, Pei Zhang, Xuan Xiang, Xiao-Shan Wei, Yi-Ran Niu, Lin-Lin Ye, Wen-Bei Peng, Si-Yu Zhang, Qian-Qian Xue, Qiong Zhou
Summary: This study found that autophagy plays an important role in early-stage lung adenocarcinoma and can be identified using the autophagy-related gene pair index (ATGPI) and autophagy clinical prognostic index (ACPI), which are associated with tumor-infiltrating lymphocytes (TILs).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Zhongxiang Liu, Koudong Zhang, Zhangyan Zhao, Zhu Qin, Haicheng Tang
Summary: This study aims to screen prognosis-related autophagy genes for female lung adenocarcinoma using transcriptome data and clinical data from the TCGA database. The results showed that the identified autophagy genes were significantly associated with prognosis and could potentially serve as targets for future treatment.
Article
Immunology
Jingyan Gao, Fei Lu, Jiawen Yan, Run Wang, Yaoxiong Xia, Li Wang, Lan Li, Li Chang, Wenhui Li
Summary: This study investigated the prognostic role of radiotherapy-related autophagy genes (RRAGs) in lung adenocarcinoma (LUAD) and identified three biomarkers. The findings enhanced the understanding of the relationship between radiotherapy, autophagy, and prognosis in LUAD and provided potential therapeutic targets for LUAD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Longhai Li, Kai Jiang, Dongpeng Li, Dongxiao Li, Zitong Fan, Guosheng Dai, Sheng Tu, Xiangyu Liu, Guangyou Wei
Summary: The study finds that high expression of CXCL7 is correlated with VEGF expression and poor prognosis in CRC patients. The combined expression of CXCL7 and VEGF can better predict patients' survival time.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Huikai Miao, Qiannan Ren, Hongmu Li, Mingyue Zeng, Dongni Chen, Chunmei Xu, Youfang Chen, Zhesheng Wen
Summary: This study revealed the significance of the autophagy-dependent ferroptosis-related gene FANCD2 in the occurrence and prognosis of LUAD. High expression of FANCD2 was associated with poor prognosis and chemotherapy resistance in LUAD patients.
Article
Cell Biology
Yuanyuan Zhang, Feng Yang, Xiaohong Peng, Xiaoyu Li, Na Luo, Wenjun Zhu, Min Fu, Qianxia Li, Guangyuan Hu
Summary: In this study, an accurate hypoxia-related prognostic model for COAD patients was established and successfully validated internally and externally. The study found correlations between hypoxia levels and immune activity, as well as conducted an in-depth exploration of common target gene mutations. The dynamic nomograph App online enhanced the clinical translational significance of the study.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Li Song, Zhiyao Chen, Menghua Zhang, Mingli Zhang, Xiaoyun Lu, Chunsun Li, Liyan Miao
Summary: The study revealed that high expression levels of DDIT4 are associated with poor overall survival in patients with LUAD, and DDIT4 serves as an independent predictor of overall survival.
Article
Oncology
Yang Yang, Mingyang Feng, LiangLiang Bai, Mengxi Zhang, Kexun Zhou, Weiting Liao, Wanting Lei, Nan Zhang, Jiaxing Huang, Qiu Li
Summary: This study identified autophagy-related genes and lncRNAs as potential prognostic and therapeutic markers for colorectal cancer (CRC), which could have important clinical applications in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Kristiaan J. Lenos, Sander Bach, Leandro Ferreira Moreno, Sanne ten Hoorn, Nina R. Sluiter, Sanne Bootsma, Felipe A. Vieira Braga, Lisanne E. Nijman, Tom van den Bosch, Daniel M. Miedema, Erik van Dijk, Bauke Ylstra, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Robert R. J. Coebergh van den Braak, Jan N. M. IJzermans, John W. M. Martens, Sally Hallam, Andrew D. Beggs, Geert J. P. L. Kops, Nico Lansu, Vivian P. Bastiaenen, Charlotte E. L. Klaver, Maria C. Lecca, Khalid El Makrini, Clara C. Elbers, Mark P. G. Dings, Carel J. M. van Noesel, Onno Kranenburg, Jan Paul Medema, Jan Koster, Lianne Koens, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. de Hingh, Maarten F. Bijlsma, Jurriaan B. Tuynman, Louis Vermeulen
Summary: A significant proportion of colorectal cancer patients develop peritoneal metastases, which are associated with poor disease outcome. This study characterizes peritoneal metastases from 52 patients and identifies a distinct molecular subtype. The researchers also discover the key role of the structural protein Moesin in peritoneal dissemination and confirm that polyclonal metastatic seeding underlies these lesions.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Shao-Wen Weng, Ting-Ting Liu, Hock-Liew Eng, Huey-Ling You, Wan-Ting Huang
Summary: This study found that CUL4A overexpression in iCCA cases was significantly associated with a higher prevalence of intact activated autophagy, advance tumor stage, less extensive necrosis, and shortened disease-free survival. In vitro, CUL4A overexpression increased autophagy and cell proliferation, suggesting that targeting autophagy may be a potential therapeutic strategy for iCCA.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Cell Biology
Suna Zhou, Xuequan Wang, Jiapei Ding, Haihua Yang, Youyou Xie
Summary: This study revealed that ATG5 plays a crucial role in regulating EMT and predicting poor prognosis in cervical cancer. The survival rate of cervical cancer patients was influenced by ATG5, and functional experiments confirmed its importance in the EMT process. Analysis of TCGA data and functional enrichment results highlighted the significant association of ATG5 with cancer-related pathways in cervical cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Guoshun Zhang, Hua Shang, Bin Liu, Guikai Wu, Diyang Wu, Liuqing Wang, Shengnan Li, Zhiyuan Wang, Suying Wang, Juxiang Yuan
Summary: ATP2A1 is a potential prognostic biomarker in colorectal cancer, with high expression associated with significantly lower overall survival rates. Inhibiting the autophagy process by ATP2A1 can significantly suppress the proliferation of colorectal cancer cells.
FRONTIERS IN GENETICS
(2022)
