Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Mimi C. Tan, Yan Liu, Massimo Rugge, Aaron P. Thrift, Hashem B. El-Serag
Summary: Hispanic and African American patients have a higher risk of gastric intestinal metaplasia detected by upper endoscopy biopsy compared to non-Hispanic white patients. This increased risk is partially independent of H. pylori infection.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paulius Jonaitis, Limas Kupcinskas, Juozas Kupcinskas
Summary: Gastric cancer is a common cause of mortality worldwide, with intestinal metaplasia considered a key factor in its development. Recent research has identified various molecular alterations in intestinal metaplasia, some of which show strong associations with the disease and potential for prevention and treatment, though study homogeneity is a key limiting factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Mimi C. Tan, Quynh Ho, Theresa H. Nguyen, Yan Liu, Hashem B. El-Serag, Aaron P. Thrift
Summary: A risk prediction model for detecting GIM in a U.S. population was developed and validated, including factors such as sex, age, race/ethnicity, smoking status, and H. pylori infection. The expanded model showed good discrimination for predicting GIM and extensive GIM, outperforming models with only H. pylori or without H. pylori in terms of AUROC.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Monika Laszkowska, Han Truong, Adam S. Faye, Judith Kim, Sarah Xinhui Tan, Francesca Lim, Julian A. Abrams, Chin Hur
Summary: 28% of individuals with GIM have the extensive subtype, and are more likely to be older and of Hispanic ethnicity. There was no difference in progression to GC between extensive and limited GIM. Further research is needed to better assess risk of GIM in the US context.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rachel Gingold-Belfer, Gania Kessler-Icekson, Sara Morgenstern, Lea Rath-Wolfson, Romy Zemel, Doron Boltin, Zohar Levi, Michal Herman-Edelstein
Summary: The study showed dysregulation of the POPDC1 and POPDC3 genes in the transition from intestinal metaplasia to gastric cancer, suggesting a role in tumor suppression and highlighting them as potential biomarkers and treatment targets for gastric cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Fen Wu, Liying Yang, Yuhan Hao, Boyan Zhou, Jiyuan Hu, Yaohua Yang, Sukhleen Bedi, Navin Ganesh Sanichar, Charley Cheng, Guillermo Perez-Perez, Wenche Tseng, Wenzhi Tseng, Mengkao Tseng, Fritz Francois, Abraham R. Khan, Yihong Li, Martin J. Blaser, Xiao-ou Shu, Jirong Long, Huilin Li, Zhiheng Pei, Yu Chen
Summary: The study suggests that certain oral and gastric microbiota are associated with the development of gastric precancerous lesions, with some bacteria enriched in cases while others under-represented compared to controls. Inflammation-related pathways may play a role in this association.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Shuangshuang Fang, Yuhan Fu, Sijing Du, Lin Wang, Xiangli Qing, Xiaoying Luo, Gengqing Song, Yang Yang, Wei Wei
Summary: This study conducted a meta-analysis to evaluate the value of EGGIM in the histological assessment of gastric intestinal metaplasia. The results showed that EGGIM is highly consistent with OLGIM, and patients with EGGIM(5-10) have a higher risk for early gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Douglas Tjandra, Rita A. Busuttil, Alex Boussioutas
Summary: Gastric adenocarcinoma is a common and lethal cancer, often asymptomatic at early stages. Gastric intestinal metaplasia (GIM) is a premalignant lesion associated with chronic inflammation, predisposing to gastric cancer. This article summarizes the best clinical practice in the diagnosis, assessment and management of GIM, as well as opportunities for precision predictions in the future.
Article
Genetics & Heredity
Biao Song, Tingting Li, Yi Zhang, Qi Yang, Bei Pei, Yun Liu, Jieyu Wang, Gang Dong, Qin Sun, Shanshan Fan, Xuejun Li
Summary: This study identified and verified the role of ferroptosis-related genes (FRGs) in gastric intestinal metaplasia (IM) through bioinformatics analysis. The results showed that HMOX1 may be a diagnostic biomarker and therapeutic target for IM.
FRONTIERS IN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Immunology
Krystal D. Kao, Helmut Grasberger, Mohamad El-Zaatari
Summary: Gastric myeloid-derived suppressor cells (MDSCs) are a population that expands during gastric pre-neoplastic and neoplastic development. S100a8 is identified as a pan-specific marker for this population, and the subset S100a8(+)Cxcr2(+) plays a role in regulating gastric immunopathology and lipid peroxidation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Zijing Xu, Ling Xiao, Shuaishuai Wang, Yuqin Cheng, Jianping Wu, Yufen Meng, Kaifan Bao, Junfeng Zhang, Chun Cheng
Summary: In this study, a rat model was used to investigate the biological mechanism of gastric intestinal metaplasia (GIM) induced by bile reflux. The results showed that GIM enhanced gastric fat digestion and absorption function, while impairing gastric acid secretion function. This effect might be mediated by the interactions among deoxycholic acid (DCA), Rikenellaceae RC9 gut group, RGD1311575 gene, and Fabp1 gene.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu
Summary: This study found that Helicobacter pylori promotes gastric intestinal metaplasia through the kynurenine pathway of tryptophan metabolism, which activates CDX2 gene expression in gastric epithelial cells. Inhibition of kynurenine aminotransferase II (KAT2) activity can reverse the effect of H. pylori on CDX2 expression.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Gastroenterology & Hepatology
Hyun Young Kim
Summary: This study aimed to evaluate the predictors of missed gastric adenoma on screening endoscopy in Korea and identify the risk factors associated with interval precancerous gastric lesions. The results showed that gastric intestinal metaplasia is an indication of missed gastric adenoma, and proper observation time can lower the possibility of missing the gastric adenoma during screening.
GASTROENTEROLOGY REPORT
(2023)
Article
Oncology
Luyao Zhang, Na Wang, Min Chen, Siran Wu, Jiaoxia Zeng, Fenli Zhou, Qiong Wu, Junye Liu, Yongquan Shi
Summary: Bile reflux is a major cause of gastric intestinal metaplasia, and research suggests that HDAC6 reduces FOXP3 expression through epigenetic modifications, leading to the inhibition of HNF4 alpha transcription and downstream intestinal markers.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
