Article
Medicine, Research & Experimental
Wen-Ying Chang, Yi-Ting Yang, Meng-Ping She, Chia-Hung Tu, Tsung-Chun Lee, Ming-Shiang Wu, Chin-Hung Sun, Ling-Wei Hsin, Linda Chia-Hui Yu
Summary: Irritable bowel syndrome (IBS) is associated with abnormal serotonin metabolism and mucosal neurite outgrowth, and 5-HT7 receptor plays a role in the process. Increased mucosal density of 5-HT7-expressing nerve fibers and elevated levels of neurotrophins contribute to visceral hypersensitivity in IBS. A novel 5-HT7 antagonist may be used as an oral analgesic for IBS-related pain.
LABORATORY INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Abraham B. Beckers, Ellen Wilms, Zlatan Mujagic, Bela Kajtar, Kata Cseko, Zsa Zsa R. M. Weerts, Lisa Vork, Freddy J. Troost, Joanna W. Kruimel, Jose M. Conchillo, Zsuzsanna Helyes, Ad A. M. Masclee, Daniel Keszthelyi, Daisy M. A. E. Jonkers
Summary: The study reveals an age-related decrease in abdominal pain perception, which may be partly related to reduced TRPA1 and/or TRPV1 receptor expression. Further research is needed to uncover precise underlying mechanisms and associations with intestinal health.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Isabelle A. M. van Thiel, Aimilia A. Stavrou, Auke de Jong, Bart Theelen, Mark Davids, Theodorus B. M. Hakvoort, Iris Admiraal-van den Berg, Isabelle C. M. Weert, Martine A. M. Hesselink-van de Kruijs, Duong Vu, Christine Moissl-Eichinger, Sigrid E. M. Heinsbroek, Daisy M. A. E. Jonkers, Ferry Hagen, Teun Boekhout, Wouter J. de Jonge, Rene M. van den Wijngaard
Summary: Irritable bowel syndrome (IBS) is a common disorder characterized by chronic abdominal pain and changes in bowel movements. Visceral hypersensitivity may be caused by intestinal fungi, but the diversity of fungal communities does not differ between IBS subgroups. The study highlights the importance of conducting strain-specific cause-and-effect studies in IBS research.
SCIENTIFIC REPORTS
(2022)
Review
Gastroenterology & Hepatology
Mariana Brizuela, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
Summary: This review discusses the underlying causes of chronic visceral pain in patients with IBS, highlighting the role of mediators and receptors that induce itch in the skin acting as gut irritants. Activation of these receptors triggers changes in neuronal excitability, leading to visceral hypersensitivity and pain, suggesting potential therapeutic targets for more effective treatment options.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu, Min Chen
Summary: This bibliometric study provides a comprehensive summary of the research trend and developments in visceral hypersensitivity in Irritable Bowel Syndrome (IBS). The study reveals that China, the United States, and Belgium are the main contributors in this field, focusing on exploring the disease mechanisms and sensitizing factors. Additionally, the study highlights the potential relationship between gut microbiota and visceral hypersensitivity, suggesting probiotics as a promising direction for future research in this area.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Lars Wilmes, James M. Collins, Kenneth J. O'Riordan, Siobhain M. O'Mahony, John F. Cryan, Gerard Clarke
Summary: The gastrointestinal microbiota plays a crucial role in gut-brain axis signaling, with alterations in gut microbiota composition often observed in patients with stress-related psychiatric disorders. Therapeutic strategies targeting the gut microbiota may be valuable for managing psychiatric symptoms associated with gut-brain axis disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Pharmacology & Pharmacy
T. Larussa, L. Abenavoli, A. Corea, A. C. Procopio, L. Giubilei, R. Vallelunga, N. Polimeni, E. Suraci, R. Marasco, M. Imeneo, L. Boccuto, F. Luzza
Summary: This study focused on the relationship between IBS severity, dietary factors, visceral sensitivity, and psychological distress. The results showed that amine-rich foods, lectin-rich foods, visceral sensitivity, and overweight may influence IBS symptoms. Clinicians should pay more attention to patients' dietary habits and personalized therapy may be beneficial for treatment.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Elahe Mousavi, Ammar Hassanzadeh Keshteli, Mohammadreza Sehhati, Ahmad Vaez, Peyman Adibi
Summary: This research uses an unsupervised machine learning algorithm to redefine subgroups of irritable bowel syndrome (IBS) based on upper gastrointestinal symptoms and psychological factors in addition to lower gastrointestinal symptoms. It discovered new homogeneous clusters in addition to well-known Rome sub-types for IBS.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Sahar M. El-Haggar, Sahar K. Hegazy, Sherief M. Abd-Elsalam, Mostafa M. Bahaa
Summary: The study suggests that pentoxifylline could be a promising adjuvant anti-inflammatory drug in the treatment of abdominal pain in IBS patients, reducing inflammation and alleviating pain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Zhong Chen, Yuan Liu, Xianhe Wu, Wei Lin, Zihan Liu, Yang Huang, Yu Chen, Ying Tang, Aiqin Chen, Chun Lin
Summary: The dysregulation of circRNAs is functionally associated with chronic pain, and this study found that circKcnk9 expression is increased in IBS-like rats. The study also revealed that circKcnk9 regulates c-Fos expression and visceral hypersensitivity through binding with miR-124-3p. This study provides a potential therapeutic target for IBS through targeting circKcnk9.
Article
Clinical Neurology
Mengyi Liu, Ziliang Ye, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Panpan He, Yuanyuan Zhang, Xianhui Qin
Summary: A study conducted in the UK Biobank found that good sleep habits and good mental health are associated with a lower risk of developing irritable bowel syndrome (IBS), with approximately 29.4% - 32.4% of the association mediated by mental health. Low psychological distress and neuroticism are also associated with an increased risk of IBS.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Gastroenterology & Hepatology
Noemi Caballero, Ingrid Marin, Fausto Riu, Carles Leal, Jordi Serra
Summary: The volume of colonic contents modulates satiety in patients with constipation-predominant irritable bowel syndrome (IBS-C) due to general visceral pan-hypersensitivity.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Axel Josefsson, Hans Tornblom, Magnus Simren
Summary: This study compared two different methods of measuring intestinal pressure and their application in IBS patients and healthy controls. The results showed that the method of measuring rectal pressure using stepwise pressure increments was more effective in identifying IBS patients with rectal hypersensitivity and its association with symptom severity.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Biotechnology & Applied Microbiology
Charlotte R. Kleiveland, Lene T. Olsen Hult, Signe Spetalen, Magne Kaldhusdal, Trine Eker Christofferesen, Oskar Bengtsson, Odd Helge Romarheim, Morten Jacobsen, Tor Lea
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2013)
Article
Clinical Neurology
Charlotte Marie Halvorsen, Frode Kolstad, John Hald, Tom Borge Johannesen, Bard Kronen Krossnes, Iver A. Langmoen, Bjarne Lied, Pal Ronning, Sigrun Skaar, Signe Spetalen, Eirik Helseth
Article
Medicine, Research & Experimental
Bjorn Bjurulf, Signe Spetalen, Aage Erichsen, Marie T. Vanier, Erik H. Strom, Petter Stromme
MEDICAL SCIENCE MONITOR
(2008)
Article
Dermatology
Steen J. Madsen, Even Angell-Petersen, Signe Spetalen, Stephen W. Carper, Sarah A. Ziegler, Henry Hirschberg
LASERS IN SURGERY AND MEDICINE
(2006)
Article
Clinical Neurology
H. Hirschberg, S. Spetalen, S. Carper, P. Hole, T. Tillung, S. Madsen
MINIMALLY INVASIVE NEUROSURGERY
(2006)
Article
Gastroenterology & Hepatology
S Spetalen, MB Jacobsen, MH Vatn, S Blomhoff, L Sandvik
DIGESTIVE DISEASES AND SCIENCES
(2004)
Article
Psychiatry
S Blomhoff, S Spetalen, MB Jacobsen, UF Malt
PSYCHOSOMATIC MEDICINE
(2001)
Article
Gastroenterology & Hepatology
S Blomhoff, S Spetalen, MB Jacobsen, M Vatn, UF Malt
DIGESTIVE DISEASES AND SCIENCES
(2000)
Article
Gastroenterology & Hepatology
S Blomhoff, S Spetalen, MB Jacobsen, M Vatn, UF Malt
DIGESTIVE DISEASES AND SCIENCES
(2000)
Article
Gastroenterology & Hepatology
S Blomhoff, MB Jacobsen, S Spetalen, A Dahm, UF Malt
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2000)
Article
Gastroenterology & Hepatology
Signe Spetalen, Leiv Sandvik, Svein Blomhoff, Morten B. Jacobsen
DIGESTIVE DISEASES AND SCIENCES
(2008)
Article
Clinical Neurology
E Angell-Petersen, S Spetalen, SJ Madsen, CH Sun, Q Peng, SW Carper, M Sioud, H Hirschberg
JOURNAL OF NEUROSURGERY
(2006)
Article
Toxicology
H Hirschberg, DR Sorensen, E Angell-Petersen, Q Peng, B Tromberg, CH Sun, S Spetalen, S Madsen
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
(2006)
Letter
Genetics & Heredity
KH Orstavik, K Eiklid, CB van der Hagen, S Spetalen, K Kierulf, O Skjeldal, K Buiting
AMERICAN JOURNAL OF HUMAN GENETICS
(2003)