MexY-Promoted Aminoglycoside Resistance in Pseudomonas aeruginosa: Involvement of a Putative Proximal Binding Pocket in Aminoglycoside Recognition

Functional Rotation Induced by Alternating Protonation States in the Multidrug Transporter AcrB: All-Atom Molecular Dynamics Simulations

(2013) Tsutomu Yamane et al.   BIOCHEMISTRY

Drug Uptake Pathways of Multidrug Transporter AcrB Studied by Molecular Simulations and Site-Directed Mutagenesis Experiments

(2013) Xin-Qiu Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Innate Aminoglycoside Resistance of Achromobacter xylosoxidans Is Due to AxyXY-OprZ, an RND-Type Multidrug Efflux Pump

(2012) Julien Bador et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reduced Expression of therplU-rpmARibosomal Protein Operon inmexXY-Expressing Pan-Aminoglycoside-Resistant Mutants of Pseudomonas aeruginosa

(2012) Calvin Ho-Fung Lau et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dissecting the function of a protruding loop in AcrB trimerization

(2012) Jun Fang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MexXY multidrug efflux system of Pseudomonas aeruginosa

(2012) Yuji Morita et al.   Frontiers in Microbiology

Vestibules Are Part of the Substrate Path in the Multidrug Efflux Transporter AcrB of Escherichia coli

(2011) F. Husain et al.   JOURNAL OF BACTERIOLOGY

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Pseudomonas Aeruginosa: Resistance to the Max

(2011) Keith Poole   Frontiers in Microbiology

Substrate path in the AcrB multidrug efflux pump of Escherichia coli

(2010) Fasahath Husain et al.   MOLECULAR MICROBIOLOGY

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies

(2009) Oded Edelheit et al.   BMC BIOTECHNOLOGY

Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update

(2009) Jessica MA Blair et al.   CURRENT OPINION IN MICROBIOLOGY

Mechanisms of RND multidrug efflux pumps

(2008) Hiroshi Nikaido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chromosomal mechanisms of aminoglycoside resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients

(2008) S. Islam et al.   CLINICAL MICROBIOLOGY AND INFECTION

Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB

(2008) J. A. Bohnert et al.   JOURNAL OF BACTERIOLOGY