Article
Infectious Diseases
Cristina Velazquez-Suarez, Ruben Cebrian, Carmen Gasca-Capote, Antonio Sorlozano-Puerto, Jose Gutierrez-Fernandez, Manuel Martinez-Bueno, Mercedes Maqueda, Eva Valdivia
Summary: Treating and controlling the spread of MRSA in hospitals is challenging due to their resistance to multiple antibiotics and ability to form biofilms. A bacteriocin called AS-48 was found to be effective against all MRSA strains, with its activity enhanced in the presence of lysozyme. Additionally, AS-48 showed efficacy in reducing the viability of S. aureus biofilms and causing changes in the structure and cell division process of the biofilms.
Article
Infectious Diseases
Takele Beyene Tufa, Asegid Guta, Tafese B. Tufa, Dereje Nigussie, Ashenafi Feyisa Beyi, Fanta D. Gutema, Fikru Regassa
Summary: This study investigated the efficacy of three brands of penicillin-streptomycin against Staphylococcus aureus isolated from cow milk in Ethiopian dairy farms. Brand A showed better efficacy compared to the other brands, which was consistent with veterinarians' perception and preference. Prudent use of brand A is crucial for effective treatment, avoiding antimicrobial resistance, and addressing animal welfare issues.
Review
Infectious Diseases
Qi Peng, Xiaohua Tang, Wanyang Dong, Ning Sun, Wenchang Yuan
Summary: Bacteria can form biofilms to protect themselves and become persistent against external challenges. Staphylococcus aureus is a common pathogen in biofilm infections. Understanding the formation and regulation mechanisms of bacterial biofilms may provide insights against antibiotic resistance.
Article
Infectious Diseases
Muhammad Yasir, Debarun Dutta, Mark D. P. Willcox
Summary: The potential use of melimine and Mel4 in combination with conventional antibiotics shows promising effectiveness in disrupting Staphylococcus aureus biofilms.
Article
Infectious Diseases
Madeeha Afzal, Ajay Kumar Vijay, Fiona Stapleton, Mark D. P. Willcox
Summary: Staphylococcus aureus isolates exhibited varying levels of resistance to antibiotics and disinfecting solutions, with microbial keratitis strains commonly showing resistance to multiple drugs. Strains from Australia were generally more susceptible to antibiotics compared to those from the USA, highlighting regional differences in resistance patterns.
Article
Chemistry, Medicinal
Carly Deusenbery, Olivia Carneiro, Carleigh Oberkfell, Anita Shukla
Summary: This study evaluated the synergistic eradication mechanism of six compounds in nine combinations against MRSA biofilms. Two promising combinations of antibiotics and antibiofilm agents were identified, providing insight for the development of effective treatments against MRSA biofilms.
ACS INFECTIOUS DISEASES
(2023)
Article
Biology
Odion O. Ikhimiukor, Stephanie S. R. Souza, Michael M. Marcovici, Griffin J. Nye, Robert Gibson, Cheryl P. Andam
Summary: Comparative genomics analysis revealed that horizontal gene transfer and the evolution of opportunistic pathogens from the Coagulase-negative Staphylococcus group are driven by overlapping ecology and geographical proximity. Coagulase-negative Staphylococcus (CoNS) are important reservoirs of diverse phages, plasmids, and mobile genes encoding antimicrobial resistance, heavy metal resistance, and virulence. Recombination between CoNS occurs frequently regardless of their animal host species, suggesting that ecological barriers to horizontal gene transfer can be overcome in co-existing lineages.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Hyochan Jang, Seong Yeol Choi, Robert J. J. Mitchell
Summary: In a survey of the International Space Station (ISS), Staphylococcus aureus was found to be the most common pathogenic bacterium in samples from air, water, and surfaces. The study showed that growth under microgravity conditions significantly altered the lipid profile of S. aureus, making it more sensitive to membrane-acting antibiotics. These findings are important for controlling the presence and spread of S. aureus and other pathogens in space.
Article
Biochemistry & Molecular Biology
Sanghun Kim, Jin-Hyung Lee, Yong-Guy Kim, Yulong Tan, Jintae Lee
Summary: The study found that hydroquinones, especially TBHQ, have inhibitory effects on biofilm formation and virulence factor production by Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Dennis Nurjadi, Quan Chanthalangsy, Elfi Zizmann, Vanessa Stuermer, Maximilian Moll, Sabrina Klein, Sebastien Boutin, Klaus Heeg, Philipp Zanger
Summary: This study identified a novel hemin-inducible heteroresistance phenotype in Staphylococcus aureus, which may be missed by standard AST methods but can be detected using Mueller-Hinton agar supplemented with horse blood. This phenomenon may partly explain the discrepancies of AST methods in determining SXT resistance in S. aureus, highlighting the importance of accurately detecting antimicrobial resistance in clinical settings.
MICROBIOLOGY SPECTRUM
(2021)
Article
Public, Environmental & Occupational Health
Zhijian Yao, Yidan Wu, Hongming Xu, Ying Lei, Wanyu Long, Meixian Li, Yue Gu, Zhiwen Jiang, Cunwei Cao
Summary: This study characterized the prevalence, clinical comorbidities, and antibiotic susceptibility of MRSA isolates from skin and soft tissue infections in Southwest China. The results showed that CA-MRSA is the predominant pathogen causing these infections, while the incidence of HA-MRSA infection is increasing. Both strains exhibited increasing antibiotic resistance. These findings provide guidance for dermatologists in choosing antibiotic treatments.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Iliana E. Escobar, Fernanda Cristina Possamai Rossatto, Soo Min Kim, Min Hee Kang, Wooseong Kim, Eleftherios Mylonakis
Summary: The kinase inhibitor Bay 11-7085 showed bactericidal activity against multidrug-resistant S. aureus and potency against Candida spp., partially inhibiting and eradicating biofilm formation. It could potentially combat biofilms associated with primary multidrug-resistant bacteria and yeast pathogens associated with wound infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Infectious Diseases
Katarzyna Garbacz, Ewa Kwapisz, Lidia Piechowicz, Maria Wierzbowska
Summary: Research on bacteriophage therapy and its use in combination with antibiotics is on the rise. A study on oral Staphylococcus aureus isolates found that the majority were susceptible to phages from an international set, with different phage groups showing associations with antibiotic sensitivity in the bacteria.
Article
Pharmacology & Pharmacy
Magda Ferreira, Sandra N. Pinto, Frederico Aires-da-Silva, Ana Bettencourt, Sandra I. Aguiar, Maria Manuela Gaspar
Summary: The study evaluated the therapeutic benefits of combining three antibiotics (vancomycin, levofloxacin, and rifabutin) with nanotechnological platforms, with RFB showing the strongest antibacterial effect when incorporated into liposomes. Negatively charged RFB liposomes showed promising potential against biofilm-associated Staphylococcus aureus infections and displayed better performance in in vitro studies. Further in vivo studies are recommended to validate the findings.
Article
Infectious Diseases
Julio E. Arce Miranda, Jose L. Baronetti, Ma Gabriela Paraje
Summary: The study demonstrates that the interaction between Staphylococcus aureus biofilms and macrophages stimulates the catabolism of L-arginine, increases ROS production, activates non-enzymatic oxidative stress response, and leads to the production of IL-6. These findings contribute to a better understanding of host-pathogen interactions.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Microbiology
Jennifer L. Dale, Julian Cagnazzo, Chi Q. Phan, Aaron M. T. Barnes, Gary M. Dunny
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Multidisciplinary Sciences
Kristi L. Frank, Paschalis Vergidis, Cassandra L. Brinkman, Kerryl E. Greenwood Quaintance, Aaron M. T. Barnes, Jayawant N. Mandrekar, M. Schlievert B. Patrick, Gary M. Dunny, Robin Patel
Article
Immunology
Aaron M. T. Barnes, Jennifer L. Dale, Yuqing Chen, Dawn A. Manias, Kerryl E. Greenwood Quaintance, Melissa K. Karau, Purna C. Kashyap, Robin Patel, Carol L. Wells, Gary M. Dunny
Editorial Material
Medical Laboratory Technology
Aaron M. T. Barnes, Ruben J. Crespo-Diaz, Justin Cohenour, Jonathan D. Kirsch, Sophie Arbefeville, Patricia Ferrieri
LABORATORY MEDICINE
(2018)
Article
Genetics & Heredity
Rebecca J. Breuer, Arpan Bandyopadhyay, Sofie A. O'Brien, Aaron M. T. Barnes, Ryan C. Hunter, Wei-Shou Hu, Gary M. Dunny
Editorial Material
Medical Laboratory Technology
Aaron M. T. Barnes, Ruben J. Crespo-Diaz, Justin Cohenour, Jonathan D. Kirsch, Sophie Arbefeville, Patricia Ferrieri
LABORATORY MEDICINE
(2018)
Article
Biotechnology & Applied Microbiology
Jennifer L. Dale, Jennifer L. Nilson, Aaron M. T. Barnes, Gary M. Dunny
NPJ BIOFILMS AND MICROBIOMES
(2017)
Meeting Abstract
Pathology
Aaron Barnes, Kristi Frank, Jennifer Dale, Dawn Manias, Jennifer Nilson, Gary Dunny
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2018)
Article
Mycology
Beth K. Thielen, Aaron M. T. Barnes, Arick P. Sabin, Becky Huebner, Susan Nelson, Elizabeth Wesenberg, Glen T. Hansen
Article
Multidisciplinary Sciences
Armin Rashidi, Maryam Ebadi, Robin R. Shields-Cutler, Kathryn Kruziki, Dawn A. Manias, Aaron M. T. Barnes, Todd E. DeFor, Patricia Ferrieri, Jo-Anne H. Young, Dan Knights, Bruce R. Blazar, Daniel J. Weisdorf, Gary M. Dunny
Article
Microbiology
Rebecca J. B. Erickson, Arpan A. Bandyopadhyay, Aaron M. T. Barnes, Sofie A. O'Brien, Wei-Shou Hu, Gary M. Dunny
JOURNAL OF BACTERIOLOGY
(2020)
Article
Microbiology
L. E. Julia Willett, L. Jennifer Dale, M. Lucy Kwiatkowski, L. Jennifer Powers, L. Michelle Korir, Rhea Kohli, M. T. Aaron Barnes, M. Gary Dunny
Summary: Enterococcus faecalis is a common commensal organism and a prolific nosocomial pathogen that causes biofilm-associated infections. This study demonstrates how E. faecalis biofilm architecture is modulated by growth medium and experimental conditions and identifies multiple new genetic determinants of biofilm formation, expanding our understanding of the genetic requirements for biofilm formation in E. faecalis.
Review
Immunology
Aaron M. T. Barnes, Kristi L. Frank, Gary M. Dunny
Summary: Enterococcus faecalis is a major opportunistic bacterial pathogen that can form stable biofilm colonies on undamaged surfaces, potentially allowing for undetected infection in asymptomatic individuals and serving as a reservoir for later clinical endocarditis. This ability to persist and hide in plain sight may contribute to the increasing clinical relevance of this pathogen in various host tissues.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Helmut Hirt, Kerryl E. Greenwood-Quaintance, Aaron M. T. Barnes, Melissa J. Karau, Lisa M. Till, Elise Palzer, Weihua Guan, Michael S. VanNieuwenhze, Purna C. Kashyap, Robin Patel, Gary M. Dunny
Summary: Microbial communities protect their hosts by excluding pathogenic invaders, and plasmid transfer and effects on host colonization of Enterococcus faecalis in the intestinal tract of mice play a key role in this process.
NATURE COMMUNICATIONS
(2022)
Meeting Abstract
Chemistry, Multidisciplinary
Arpan Bandyoapdhyay, Pranav Agrawal, Rebecca Breuer, Aaron Barnes, Dawn Manias, Kevin Dorfman, Gary Dunny, Wei-Shou Hu
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)