期刊
MATHEMATICAL MODELLING OF NATURAL PHENOMENA
卷 3, 期 5, 页码 1-15出版社
EDP SCIENCES S A
DOI: 10.1051/mmnp:2008074
关键词
polymer deposition; stimuli-responsive polymers; drug release; fluid and solid mechanics; probability theory
类别
资金
- National Science Foundation [NIRT CTS-0609062, CBET-0543538]
Stimuli-responsive polymers result in on-demand regulation of properties and functioning of various nanoscale systems. In particular, they allow stimuli-responsive control of flow rates through membranes and nanofluidic devices with submicron channel sizes. They also allow regulation of drug release from nanoparticles and nanofibers in response to temperature or pH variation in the surrounding medium. In the present work two relevant mathematical models are introduced to address precipitation-driven deposition of surface layers of stimuli-responsive polymers and describe a possible effect of swelling-shrinkage transition of such polymers on drug release.
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