Article
Chemistry, Physical
Aiman Karim, Abdur Rehman, Jianguo Feng, Asia Noreen, Elham Assadpour, Mohammad Saeed Kharazmi, Zhang Lianfu, Seid Mahdi Jafari
Summary: Alginate-based nanocarriers have great potential in the delivery of bioactive compounds. Calcium alginate and sodium alginate, as the most promising wall materials, are non-toxic, relatively cheap, simple to produce, and biocompatible and biodegradable. The review discusses different alginate-based nanocarriers and their entrapment of bioactives, as well as their bioavailability in the gastric environment. Alginate-based nanocarriers can be used as emulsifiers/encapsulants for various bioactives, including vitamins, minerals, peptides, essential oils, and carotenoids. The combination of alginate-based nanocarriers with other polysaccharides/emulsifiers is recognized as the most effective approach for the protection, delivery, and sustained release of bioactives.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Mohammed Bhia, Mahzad Motallebi, Banafshe Abadi, Atefeh Zarepour, Miguel Pereira-Silva, Farinaz Saremnejad, Ana Claudia Santos, Ali Zarrabi, Ana Melero, Seid Mandi Jafari, Mehdi Shakibaei
Summary: Naringenin possesses various pharmacological properties, but its therapeutic potential is limited by its hydrophobic nature, which can be overcome by using nanocarriers for delivery. In vitro, ex vivo, and in vivo studies have demonstrated the potential therapeutic effects of naringenin for various diseases when formulated in appropriate nanocarriers.
Review
Food Science & Technology
Devendrasingh Tomar, Pankaj K. Singh, Sajidul Hoque, Sheela Modani, Anitha Sriram, Rahul Kumar, Jitender Madan, Dharmendra Khatri, Kamal Dua
Summary: Amorphous solid products are key solutions to improve the solubility and bioavailability of poorly soluble nutraceuticals. Stabilizing the amorphous form through methods like solid dispersion and co-amorphous can enhance the dissolution and bioavailability of nutraceuticals. This review presents an application of amorphous systems in delivering poorly soluble nutraceuticals to overcome their pharmacokinetic limitations.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Food Science & Technology
Rakesh Kumar Dhritlahre, Ruchika, Yogendra Padwad, Ankit Saneja
Summary: Self-emulsifying formulations have potential to enhance the oral bioavailability and therapeutic efficacy of nutraceuticals through various mechanisms such as reducing intra-enterocyte metabolism, inhibiting efflux transporter, and bypassing hepatic first-pass metabolism.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Applied
Runan Zhao, Weiting Fu, Yijie Chen, Bin Li, Shilin Liu, Yan Li
Summary: The study investigated the effect of CA on WPI, showing that the WPI/CA complex can act as a stabilizer to form emulsions and emulsion gels for better protection and enhanced bioaccessibility of beta-carotene. The findings provide insights into developing new multifunctional food ingredients and improving protein modification in food systems.
Review
Food Science & Technology
Xing Chen, Yan Chen, Yikun Liu, Liqiang Zou, David Julian McClements, Wei Liu
Summary: This article reviews the studies on the use of emulsions to improve the bioavailability of nutraceuticals, and the findings can facilitate the design of more efficacious nutraceutical-loaded emulsions with increased bioactivity.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Chemistry, Physical
Asli Can Karaca, Elham Assadpour, Seid Mahdi Jafari
Summary: Emulsion-based delivery systems (EBDSs) can effectively carry bioactive compounds (bioactives). Plant proteins (PLPs) have been found to be potential stabilizers of emulsions for loading, protection and delivery of bioactives. Various strategies can be used to alter the characteristics of PLPs and improve their emulsification and encapsulation performance. The stability, release, and bioavailability of encapsulated bioactives can be customized by optimizing the processing conditions and emulsion formulation. This paper provides cutting-edge information on PLP-based emulsions carrying bioactives, including preparation methods, physicochemical characteristics, stability, encapsulation efficiency and release behavior. Strategies for enhancing the emulsifying and encapsulation properties of PLPs in EBDSs are also reviewed, with a focus on the use of PLP-carbohydrate complexes for stabilizing bioactive-loaded emulsions.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Nutrition & Dietetics
Alessandro Colletti, Andrea Fratter, Marzia Pellizzato, Giancarlo Cravotto
Summary: The use of nutraceuticals for the treatment of dyslipidemia is increasing, but many products are poorly formulated and fail to ensure efficacy. Bioavailability and bioaccessibility of active compounds are crucial issues that are often overlooked. Research suggests that many products are insufficient in ensuring full enteric absorption.
Article
Food Science & Technology
Antonia Goncalves, Berta N. Estevinho, Fernando Rocha
Summary: The food industry is focused on meeting consumer demands by investing in innovative products that incorporate bioactive compounds to improve human health. Encapsulation technology is a promising strategy to enhance the stability and bioavailability of lipophilic bioactive compounds. Controlled delivery nano- and microsystems can protect and increase the stability of these compounds, ultimately promoting their bioactivity in food formulations and improving their bioaccessibility in the human body.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roberto Castro-Munoz, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: Nowadays, there is a growing awareness in society towards healthy food products and their health benefits due to the bioactive compounds they contain. However, the long-term stability and effectiveness of these compounds are compromised by environmental factors. Lab-designed vehicles, such as nanoparticles and nanofibers, offer a solution by providing properties for preservation and suitable delivery. Chitosan, among other biopolymers, is commonly used as a material for designing electrospun nanofibers and nanocarriers for the encapsulation of bioactive compounds. This review focuses on the latest advances in this field over the past 2-3 years, particularly in the context of smart food packaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Gjylije Hoti, Adrian Matencio, Alberto Rubin Pedrazzo, Claudio Cecone, Silvia Lucia Appleton, Yousef Khazaei Monfared, Fabrizio Caldera, Francesco Trotta
Summary: Nutraceuticals are compounds with valuable biological activities and health-promoting effects. The usage of nutraceuticals is limited by various factors, which can be overcome by nanotechnology. The application of nanomaterials-based drug delivery systems, such as modified cyclodextrin-based nanosponges, can improve the solubility, stability, and bioavailability of nutraceuticals. This review highlights the potential of nanosystems based on linear dextrins for nutraceutical delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Applied
Yongkai Yuan, Mengjie Ma, Shuaizhong Zhang
Summary: This review discusses the use of delivery systems to improve the application of fucoxanthin derived from marine algae/microalgae. The delivery systems, such as nanoparticles, microcapsules, emulsions, gels, coacervates, and nanofibers, showed positive effects on the stability, release, bioavailability, and bioactivity of fucoxanthin. However, the reported applications of fucoxanthin in food are limited, and there is a need to establish internationally unified evaluation criteria for its stability and bioavailability.
Review
Food Science & Technology
Tongwei Guan, Zhiheng Zhang, Xiaojing Li, Shaoning Cui, David Julian McClements, Xiaotian Wu, Long Chen, Jie Long, Aiquan Jiao, Chao Qiu, Zhengyu Jin
Summary: Plant protein-based carriers can improve the water solubility, stability, and bioavailability of bioactive substances and have wide application prospects.
Review
Polymer Science
Tiago C. Pinto, Artur J. Martins, Lorenzo Pastrana, Maria C. Pereira, Miguel A. Cerqueira
Summary: Oleogels are semi-solid materials with a large fraction of liquid oil, used in the food industry to mimic fats and deliver bioactive compounds. Interest in these structures has been growing, with research focusing on new molecules, gelation methods, and potential applications.
Review
Food Science & Technology
Parthasarathi Subramanian
Summary: Oral mucosa has been recognized as a potential site for enhancing the bioavailability of bioactive compounds. Mucoadhesive formulations can improve retention and permeability of bioactive compounds, offering a convenient and simple way to increase their concentration in plasma.
Article
Food Science & Technology
Yuwen Ting, Yi-Shiou Chiou, Yike Jiang, Min-Hsiung Pan, Zhengyu Lin, Qingrong Huang
FOOD RESEARCH INTERNATIONAL
(2015)
Article
Medicine, Research & Experimental
Yuwen Ting, Yike Jian, Yaqi Lan, Chunxin Xia, Zhenyu Lin, Michael A. Rogers, Qingrong Huang
MOLECULAR PHARMACEUTICS
(2015)
Article
Chemistry, Applied
Ping Shao, Jiamei Shao, Yike Jiang, Peilong Sun
CARBOHYDRATE POLYMERS
(2016)
Article
Agriculture, Multidisciplinary
Weiping Jin, Jieyu Zhu, Yike Jiang, Ping Shao, Bin Li, Qingrong Huang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Food Science & Technology
Yuwen Ting, Yike Jiang, Shuqi Zhao, Cohn C. Li, Traj Nibber, Qingrong Huang
JOURNAL OF FUNCTIONAL FOODS
(2018)
Article
Nanoscience & Nanotechnology
Luyao Wei, Zhiquan Lu, Xiang Ji, Yike Jiang, Lan Ma
Summary: Hollow graphene oxide microcapsules prepared using liquid nitrogen cavitation effects showed potential as drug carriers due to their unique properties and good drug loading capacity, exhibiting excellent cytotoxicity to cancer cells and pH-dependent drug release performance.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Oncology
Wenning Cao, Yike Jiang, Xiang Ji, Lan Ma
Summary: An immune-related gene signature of breast cancer was identified in this study, which could be used as potential prognostic and therapeutic targets. Breast cancer patients were stratified into low- and high-risk groups based on the immune-related prognostic scores, with patients in the high-risk group associated with worse outcomes and fewer tumor-infiltrated immune cells.
Article
Oncology
Wenning Cao, Yike Jiang, Xiang Ji, Xuejiao Guan, Qianyu Lin, Lan Ma
Summary: The study identified 16 genes significantly associated with triple-negative breast cancer through bioinformatic analyses. Among these genes, HSPB1, IFI16, and TPX2 may serve as potential biomarkers for TNBC. The pathways involved by these genes mainly include cell cycle, oocyte meiosis, and spliceosome.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yike Jiang, Ziyi Jiang, Lan Ma, Qingrong Huang
Summary: Catechins in green tea, as a dominant phenolic component with anticancer activity, may have compromised efficacy due to low oral bioavailability. Nanodelivery systems have emerged as a promising approach to enhance oral bioavailability and anticancer activity of catechins. Active research has been conducted in recent decades to explore the molecular mechanisms and advancements in delivering catechins using nanodelivery systems for enhanced anticancer effects.
Review
Pharmacology & Pharmacy
Yike Jiang, Ziyi Jiang, Mingzhe Wang, Lan Ma
Summary: Breast cancer is a frequently diagnosed cancer threatening women's lives, and nanomedicines offer a new hope for its treatment by addressing the limitations of traditional therapies and achieving precise drug delivery to tumors.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Yike Jiang, Weiping Jin, Qingrong Huang
Summary: Nanocomplexes assembled from chitosan and caseinophosphopeptides were utilized to stabilize Pickering emulsions with medium-chain triglyceride as the oil phase. The concentration of nanocomplexes and their ratio impacted the stability of the emulsion, showing potential as fat replacers in food products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Multidisciplinary
Yike Jiang, Ting Zheng, Weiping Jin, Yuxin Shi, Qingrong Huang
Summary: This study utilized chitosan and caseinophosphopeptides to improve the intestinal permeability of theaflavin-3,3'-digallate. The complexation between chitosan and caseinophosphopeptides was mainly driven by electrostatic interaction. The optimized nanocomplex successfully encapsulated theaflavin-3,3'-digallate and enhanced its intestinal permeability.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zeyang Liu, Haochen Nan, Yike Jiang, Tao Xu, Xiaohua Gong, Chengzhi Hu
Summary: Encapsulation of live cells in protective, semipermeable microcapsules is a key technique for in vitro tissue regeneration, cell therapies, and pharmaceutical screening. This study proposes a novel method for developing programmable Janus APA microcapsules with variable shapes and sizes by using electrodeposition, allowing for precise spatial patterning of heterotypic cells inside the APA microcapsule to observe cellular growth, interactions, and differentiation in a controlled environment.
Article
Biochemistry & Molecular Biology
Yike Jiang, Weiping Jin, Jessica Li, Qingrong Huang
Summary: The study revealed that TF-3 primarily interacted with CPPs through hydrogen bonding, leading to the aggregation of CPPs. The binding of TF-3 to CPPs enhanced the cellular antioxidant activity of TF-3.
