期刊
JOURNAL OF FUNCTIONAL FOODS
卷 2, 期 3, 页码 179-186出版社
ELSEVIER
DOI: 10.1016/j.jff.2010.04.006
关键词
Cholesterol; Crataegus pinnatifida; Dietary supplement; Hawthorn; High-fat diet; Rat
资金
- Shenzhen Virtual University Park, Shenzhen Government
- Niche Area Research Grant from the Hong Kong Polytechnic University
- Chinese University of Hong Kong
- RGC Earmarked Grants of Hong Kong SAR [4107/01M, 4166/02M, CUHK467807]
- Chinese University of Hong Kong [2401149, 2041231]
The hypocholesterolemic and atheroscleroprotective potentials of dietary consumption of hawthorn (dried fruit of Crataegus pinnatifida, Shan Zha) were investigated by monitoring plasma lipid profiles and aortic relaxation in Sprague-Dawley rats fed with either normal diet, high-cholesterol diet (HCD) or HCD supplemented with hawthorn powder (2%, w/w) (4 weeks). In HCD-fed rats, an increased plasma total cholesterol and LDL-cholesterol with a decreased HDL-cholesterol was observed, and consumption of hawthorn markedly suppressed the elevated total cholesterol and LDL-lipoprotein levels plus an increased HDL-cholesterol level. The blunted acetylcholine-induced, endothelium-dependent relaxation of isolated aortas of HCD-fed rats was improved by hawthorn. The development of fatty liver, an increased nitric oxide synthase (NOS) activity and an elevated oxidative stress (as estimated by the attenuated levels of anti-oxidant enzymes) associated with HCD were attenuated by hawthorn. Thus, the results demonstrated that hawthorn consumption provides overall beneficial effects on reversing HCD associated detrimental changes. (C) 2010 Elsevier Ltd. All rights reserved.
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