期刊
MEDCHEMCOMM
卷 4, 期 6, 页码 1001-1005出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00050h
关键词
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资金
- Fund of the Science and Technology Commission of Shanghai Municipality [11nm0506400, 12520705500, 11JC1410500]
- National Natural Science Foundation of China [21273032, 81101150, 81271384]
- Program for New Century Excellent Talents in University, State Education Ministry
- Fundamental Research Funds for the Central Universities
- FCT [PTDC/CTM-NAN/1748/2012]
Generation 5-poly(amidoamine) dendrimers pre-modified with folic acid and methotrexate (G5-FA-MTX) were used as templates for the synthesis of dendrimer-entrapped gold nanoparticles (Au DENPs). The synthesized [(Au-0)(50)-G5-FA-MTX] DENPs were able to target and specifically inhibit the growth of cancer cells overexpressing high affinity folic acid receptors.
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