3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors

A series of quinoline derivatives were designed and synthesized as tyrosine kinase inhibitors. Exploration of the structure-activity relationships resulted in compounds that are potent in vitro. In addition, compound 10f was found to be a potent and selective Raf kinase inhibitor.