期刊
MEDCHEMCOMM
卷 4, 期 5, 页码 852-855出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00017f
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资金
- MRC [G0900903] Funding Source: UKRI
- Medical Research Council [G0900903] Funding Source: researchfish
Formation of neurofibrillary tangles, comprising of microtubule-associated tau protein, is a hallmark of a group of neurodegenerative diseases, including Alzheimer's disease. In consequence, in vivo imaging of neurofibrillary tangles is a current focus of positron emission tomography research. Herein, development of an in vitro radioligand binding assay which uses synthetic aggregates as a model of neurofibrillary tangles is reported, together with evaluation of novel derivatives of the tau protein ligand astemizole.
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