期刊
MEDCHEMCOMM
卷 3, 期 5, 页码 580-583出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2md00311b
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资金
- National Institute of Mental Health (NIMH) [1R43084765]
- National Science Foundation (MRI) [CHE-0420497]
A new pentacyclic compound, DDD-016 (10d) was designed and synthesized as a potential antipsychotic and screened for binding affinity in a broad panel of over 80 CNS and other receptors, monoamine transporters, and ion channels. The resulting receptor binding profile of DDD-016 is consistent with that of an improved atypical antipsychotic candidate.
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