Article
Biochemistry & Molecular Biology
Jing Li, Ru Si, Qingqing Zhang, Yanchen Li, Jie Zhang, Yuanyuan Shan
Summary: Based on the scaffold hybridization strategy, twenty-four indole-guanidines were designed and synthesized. Most of these hybrids exhibited moderate to high anti-proliferative activity against various cancer cells, especially human hepatoma cell lines. Selectivity investigation showed that the hybrids had the best selectivity for the SMMC-7721 subtype in human hepatoma cells. Particularly, compound 22 demonstrated potent inhibition against SMMC-7721 cells, inducing apoptosis and cell cycle arrest in a dose-dependent manner, while down-regulating the expression of specific proteins.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Medicinal
Chao Liu, Yuan-Yuan Xu, Zhao-Hui Wen, Yue-Hui Dong, Zhao-Peng Liu
Summary: The study reported the synthesis and evaluation of antitumor activity of two series of BU-4664L derivatives. All derivatives displayed micromolar activity against PC-3 cells, with 10a and 16c showing the most promising antiproliferative activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Shuang Chen, Ze-Hua Yu, Wei-Na Wang, Zi-Yue Chen, Bo-Wen Pan, Lin Chen, Ying Zhou, Xiong-Wei Liu, Xiong-Li Liu
Summary: In this study, the natural product harmaline and its derivatives were utilized as N-C synthons in formal [3+2] cycloadditions with isothiocyanates, leading to the construction of a library of spiropolycyclic harmaline-based hybrids with two adjacent quaternary stereocentres. These compounds were obtained in high yield and selectivity, under mild conditions using Et3N as the catalyst. The synthesized compounds were evaluated for their anticancer activities, and compound 3cb showed the best activity similar to cisplatin against A549 cells, indicating its potential as a lead compound for drug development.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Sung-Bau Lee, Ting-Yu Chang, Nian-Zhe Lee, Zih-Yao Yu, Chi-Yuan Liu, Hsueh-Yun Lee
Summary: This study introduces novel bisindole molecules as anti-cancer agents that effectively inhibit TLKs activity and demonstrated their anti-cancer effects in vitro. Through structure optimization, six derivatives with potent TLK inhibitory activity were identified, with potential applications in the treatment of various cancers.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Abdelmoula El Abbouchi, Nabil El Brahmi, Marie -Aude Hiebel, Jerome Bignon, Gerald Guillaumet, Franck Suzenet, Said El Kazzouli
Summary: A novel class of ethacrynic acid derivatives containing triazole moieties were designed, synthesized and evaluated as new anticancer agents. Compound 3c exhibited very good antitumor activities with high safety index and selectivity against various cancer cell lines. Both compounds induced mitochondrial dysfunctions causing caspase-induced apoptosis in HCT116 cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Wen Peng, Fuyao Liu, Lei Zhang, Liying Zhang, Jing Li
Summary: Tetrazole was used to replace the carboxyl-thiazole fragment of febuxostat to design three series of compounds as xanthine oxidoreductase (XOR) inhibitors. The inhibitory activity against XOR was evaluated, and compounds with significantly increased activity were identified. Molecular docking analysis showed that tetrazole could effectively replace the carboxyl group in the active cavity of XOR. In vivo studies in mice confirmed the hypouricemic effects of the most potent compounds identified. This study provides new insights and potential candidates for the design of XOR inhibitors.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Valeria Stefanizzi, Antonella Minutolo, Elena Valletta, Martina Carlini, Franca M. M. Cordero, Anna Ranzenigo, Salvatore Pasquale Prete, Daniel Oscar Cicero, Erica Pitti, Greta Petrella, Claudia Matteucci, Francesca Marino-Merlo, Antonio Mastino, Beatrice Macchi
Summary: Metal-derived platinum complexes are commonly used in the treatment of solid tumors. However, the toxicity and resistance of these drugs necessitate the search for alternative compounds. Organotin compounds have shown potential in inhibiting cell growth and inducing cell death and autophagy. In this study, the biological activities of different organotin compounds were evaluated, and it was found that tributyltin compounds were more cytotoxic than cisplatin. Additionally, the mechanism of action was attributed to the inhibition of glucose uptake. Furthermore, the tumorigenicity of the cells influenced their susceptibility to the compounds, with highly tumorigenic cells being less affected.
Article
Chemistry, Physical
Zhifen Li, Ming Tian, Jingbo Ma, Siyu Xia, Xiannian Lv, Peng Xia, Xiaolong Xu, Yuke Jiang, Jigang Wang, Zhijie Li
Summary: Eight bis-chalcone conjugates with lysine linker were synthesized and evaluated for their antiproliferative potential. The derivatives showed good sensitivity against gastric cancer cells TMK1 and AGS, with compound 3a exhibiting the most potent activity. In vivo studies demonstrated that compound 3a effectively inhibited tumor growth in a xenograft model. The mechanism of action of 3a in tumor growth inhibition was further investigated, revealing a positive regulation of apoptotic signaling pathway.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Shuhua Luo, Xin Dang, Juntao Wang, Chang Yuan, Yixin Hu, Shuwen Lei, Yang Zhang, Dan Lu, Faqin Jiang, Lei Fu
Summary: This study investigated the inhibitory activity of mitochondria targeting small molecules on human cervical cancer cells and demonstrated their therapeutic potential. In both in vitro and in vivo experiments, these molecules showed promising inhibitory effects on cancer cells, promoting potential apoptosis and necrosis.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Harshita Sachdeva, Sarita Khaturia, Mohammad Saquib, Narsingh Khatik, Abhinav Raj Khandelwal, Ravina Meena, Khushboo Sharma
Summary: Oxygen- and sulphur-based heterocycles, which are the core structure of many biologically active molecules and FDA-approved drugs, have a wide range of biological activities. In recent years, they have gained more attention as potential innovative anticancer drugs. Fused oxygen- and sulphur-based heterocyclic derivatives have been synthesized in attempts to improve the biological profile of molecules. Additionally, fused heterocycles behave as DNA intercalating agents, interacting with DNA and inducing cell death to exert their anticancer effects.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrey Smolobochkin, Almir S. Gazizov, Lola J. Yakhshilikova, Dmitrii D. Bekrenev, Alexander R. Burilov, Michail A. Pudovik, Anna P. Lyubina, Syumbelya K. Amerhanova, Alexandra D. Voloshina
Summary: A series of novel taurine-derived compounds with antibacterial and antifungal activity were synthesized using a modular three-stage approach. Some of the synthesized compounds showed higher activity and bactericidal effect, making them promising candidates for further studies.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Yichang Ren, Yong Ruan, Binbin Cheng, Ling Li, Jin Liu, Yuyu Fang, Jianjun Chen
Summary: Compound 3b, designed as a tubulin inhibitor targeting the colchicine binding site, showed high antiproliferative activity against HepG-2 cells, with the ability to suppress microtubule polymerization, disrupt dynamics, inhibit cancer cell migration, induce cell cycle arrest and apoptosis. Docking studies indicated its potential as a novel tubulin inhibitor deserving further investigation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Leila Emami, Soghra Khabnadideh, Zahra Faghih, Farnoosh Farahvasi, Fatemeh Zonobi, Saman Zare Gheshlaghi, Shadi Daili, Ali Ebrahimi, Zeinab Faghih
Summary: A series of quinazolinone derivatives were synthesized as antiproliferative agents and evaluated for their structure and cytotoxic activity. Molecular docking studies confirmed their potential anticancer activity and most of the compounds fulfilled drug design rules. With further modification, these compounds could be promising antiproliferative agents.
Article
Chemistry, Medicinal
Nataliya Finiuk, Anna Kryshchyshyn-Dylevych, Serhii Holota, Olga Klyuchivska, Andriy Kozytskiy, Olexandr Karpenko, Nazar Manko, Iryna Ivasechko, Rostyslav Stoika, Roman Lesyk
Summary: A series of novel pyrrolidinedione-thiazolidinones were synthesized and evaluated for their anticancer potential. The compounds showed high antiproliferative activity and cytotoxicity against various cancer cell lines, while exhibiting low toxicity towards normal human cells. The compounds also demonstrated selective cytotoxicity towards leukemia, lung, breast, cervical, colon carcinoma, and glioblastoma cells. The mechanism of action involved mitochondria-dependent apoptosis and DNA damage in treated cancer cells. These findings suggest that the novel hybrid pyrrolidinedione-thiazolidinones have potential as anticancer agents with reduced toxicity towards normal cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Alberto Pla-Lopez, Raquel Castillo, Rocio Cejudo-Marin, Olaya Garcia-Pedrero, Mariam Bakir-Laso, Eva Falomir, Miguel Carda
Summary: Twenty-six triazole-based derivatives were designed to target both PD-L1 and VEGFR-2. These compounds were evaluated for their biological effects on VEGFR-2, PD-L1, and c-Myc proteins, with compound 23 showing promising results. The antiangiogenic and antivascular activities of chloro derivatives were also confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Kannikanti Gavash Harsha, Chakali Madhu, Nagaprasad Puvvada, Tulsidas Ramachandra Rao Baggi, Vaidya Jayathirtha Rao, Narendra Reddy Chereddy
Article
Chemistry, Physical
Ejjurothu Appalanaidu, V. M. Vidya, Manohar Reddy Busireddy, Jayathirtha Rao Vaidya, Prabhakar Chetti
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Article
Chemistry, Multidisciplinary
Lakshmireddy Vanammoole, Rajkumar Kommera, Siva Hariprasad Kurma, Jayathirtha Rao Vaidya, China Raju Bhimapaka
Article
Thermodynamics
P. Yella Reddy, T. Srinivasa Krishna, M. Gowrisankar, K. Siva Kumar, Chebolu Naga Sesha Sai Pavan Kumar
Summary: The study found evidence of complex formation between unlike molecules, with FT-IR properties showing hydrogen bond formation between unlike molecules and good agreement among excess parameters and FT-IR spectroscopic properties.
JOURNAL OF CHEMICAL THERMODYNAMICS
(2021)
Article
Biochemical Research Methods
Naga Veera Yerra, Bharath Dyaga, S. Babu Dadinaboyina, Sukanya Pandeti, Jayathirtha Rao Vaidya, Jean-Claude Tabet, Jagadeshwar Reddy Thota
Summary: The low-cost synthetic CTA matrix is a versatile option for analyzing a wide range of compounds in positive-ion mode, including high molecular mass PEGs and proteins. Its high signal-to-noise ratios and spectral resolutions offer advantages over conventional matrices.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Chemistry, Multidisciplinary
Ejjurothu Appalanaidu, Manohar Reddy Busireddy, Katta Eswar Srikanth, B. V. Subba Reddy, Vaidya Jayathirtha Rao, Renjith Thomas
Article
Chemistry, Physical
Madhu Chakali, Haraprasad Mandal, Munisamy Venkatesan, Bharath Dyaga, V. Jayathirtha Rao, Prakriti Ranjan Bangal
Summary: A push-pull type triad was synthesized, and its ultrafast relaxation dynamics in solution phase was explored using various spectroscopic methods. The study revealed the possibility of electron transfer within the triad, as well as the occurrence of singlet fission events in DPP derivatives in a 100-200 ps time scale. These findings could have implications for device design.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Physical
Gorakala Umasankar, Hidayath Ulla, Chakali Madhu, Gontu Ramanjaneya Reddy, Balaiah Shanigaram, Jagadeesh Babu Nanubolu, Bhanuprakash Kotamarthi, Galla V. Karunakar, M. N. Satyanarayan, V. Jayathirtha Rao
Summary: A series of multichromophoric small molecules based on pyrene-imidazole-phenyl hybrids were designed for blue OLED applications. These molecules exhibited delayed fluorescence, high triplet energies, appropriate HOMO/LUMO energy levels, and stable thermal performance. OLED devices doped with PI showed excellent device performance with high efficiency.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Energy & Fuels
P. Yella Reddy, T. Srinivasa Krishna, M. Gowrisankar, K. Siva Kumar, Chebolu Naga Sesha Sai Pavan Kumar
Summary: The study measured densities, speeds of sound, and viscosities of binary mixtures of formamide with aniline, N-methylaniline, and N,N-dimethylaniline, and analyzed the consistency between excess parameters and FT-IR spectroscopic properties.
INTERNATIONAL JOURNAL OF AMBIENT ENERGY
(2021)
Article
Chemistry, Physical
P. Yellareddy, S. K. Fakruddin Babavali, T. Srinivasa Krishna, M. Gowrisankar, Ch N. S. S. Pavan Kumar
Summary: This study reports the densities, viscosities, and speeds of sound for binary mixtures of tetrachloromethane with ortho-substituted aniline, and analyzes the specific interactions such as hydrogen bonding between unlike molecules. Good agreement is observed between the excess parameters and FT-IR properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
P. Yellareddy, Chebolu Naga Sesha Sai Pavan Kumar, M. Gowrisankar, Shaik Babu, M. Rathnam
Summary: The study measured the physical properties of binary mixtures of 2,6-dimethylcyclohexanone with substituted anilines and aniline, and calculated various property deviations using experimental data, applying different theoretical models for analysis. The results showed good agreement among the excess parameters and FT-IR spectroscopic properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Multidisciplinary Sciences
Jagadees Kumar Gangasani, Siwaswarup Yarasi, Vegi Ganga Modi Naidu, Jayathirtha Rao Vaidya
Summary: This chapter focuses on the synthesis, characterization, evaluation of anticancer properties, and the journey of triazine-based derivatives towards potential cancer medicine.
PHYSICAL SCIENCES REVIEWS
(2022)
Review
Multidisciplinary Sciences
Jayathirtha Rao Vaidya, Yadavalli Venkata Durga Nageswar
Summary: Green-bond forming reactions using polyaniline (PANI) as a catalyst play a crucial role in organic synthesis. This chapter focuses on the preparation and characterization of PANI catalyst, as well as its application in the synthesis of heterocycles.
PHYSICAL SCIENCES REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Suhas Ravindra Bavikar, Hong-Jay Lo, Chebolu Naga Sesha Sai Pavan Kumar, Rong-Jie Chein
Summary: Herein, an enantioselective total synthesis of (-)-panduratin D, a novel secondary metabolite against human pancreatic cancer cells, is reported. The synthesis was completed in nine steps and involved various key features including Sonogashira coupling, anionic Snieckus-Fries rearrangement, directed ortho metalation, tandem Si -> C alkyl rearrangement/Claisen-Schmidt condensation, and chiral boron complex-promoted asymmetric Diels-Alder cycloaddition.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kannikanti Gavash Harsha, Boddu Ananda Rao, Tulsidas R. Baggi, S. Prabhakar, V. Jayathirtha Rao
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2020)