期刊
MEDCHEMCOMM
卷 2, 期 7, 页码 579-584出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0md00266f
关键词
-
资金
- Dublin Institute of Technology
- Irish National Development Plan
Dinuclear Cu2+ and Mn2+ bis-phenanthroline octanedioate compounds exhibit rapid, unprecedented nano and picomolar in vitro cytotoxicity against human-derived colorectal cancer lines (HT29, SW480 and SW620) and are less cytotoxic toward non-cancerous normal human keratinocyte cells (HaCaT). Both complexes displayed greater in vivo drug tolerance compared to cisplatin when examined using the insect Galleria mellonella. The compounds are potent generators of intracellular reactive oxygen species within HT29 cells, display avid DNA binding and induce O-2-dependent cleavage of supercoiled pUC18 DNA. The Cu2+ complex was found to display self-cleaving nuclease activity and a mechanism of deoxyribose C-H bond activation is proposed, based on interactions with the superoxide anion and hydrogen peroxide along with DNA cleavage observations under anaerobic conditions and with an excess of the metal chelator EDTA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据