Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

Glucokinase activators as potential antidiabetic agents possessing superior glucose lowering efficacies

(2015) M.C.T. Fyfe et al.   DRUGS OF THE FUTURE

Novel glucokinase activators: a patent review (2008 – 2010)

(2010) Ramakanth Sarabu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study

(2010) Riccardo C. Bonadonna et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Discovery, Structure−Activity Relationships, Pharmacokinetics, and Efficacy of Glucokinase Activator (2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675)

(2010) Nancy-Ellen Haynes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle

(2009) Jeffrey A. Pfefferkorn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes

(2009) Gregory R. Bebernitz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Sonogashira Reactions with Propyne: Facile Synthesis of 4-Hydroxy-2-methylbenzofurans from Iodoresorcinols

(2009) Martin A. Berliner et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Spirocyclic Oxetanes: Synthesis and Properties

(2008) Georg Wuitschik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Physiology of Mammalian Glucokinase

(2008) P. B. Iynedjian   CELLULAR AND MOLECULAR LIFE SCIENCES

Glucokinase activators in diabetes management

(2008) Matthew Coghlan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Glucokinase activators as new type 2 diabetes therapeutic agents

(2008) Ramakanth Sarabu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Enantioselective Pd-Catalyzed α-Arylation ofN-Boc-Pyrrolidine: The Key to an Efficient and Practical Synthesis of a Glucokinase Activator

(2008) Artis Klapars et al.   JOURNAL OF ORGANIC CHEMISTRY