期刊
MEDCHEMCOMM
卷 2, 期 3, 页码 190-195出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0md00231c
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资金
- Centre National de la Recherche Scientifique (CNRS)
- Institut National de la Sante et de la Recherche Medicate (Inserm)
- Institut National du Cancer (INCa, Boulogne Billancourt, France)
- Gottlieb Daimler-and Karl Benz-Foundation
- Association pour la Recherche contre le Cancer (ARC, Villejuif)
With the purpose to improve the biological activities of curcumin, eight novel ferrocenyl curcuminoids were synthesized by covalent anchorage of three different ferrocenyl ligands. We evaluated their cytotoxicity on B16 melanoma cells and normal NIH 3T3 cells, their inhibition of tubulin polymerization and their effect on the morphology of endothelial cells. The presence of a ferrocenyl side chain was clearly shown to improve the biological activity of most of their corresponding organic curcuminoid analogues.
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