期刊
MEDCHEMCOMM
卷 1, 期 3, 页码 202-208出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0md00095g
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资金
- The Cambridge Cancer Research UK
- Cancer Research UK [6934] Funding Source: researchfish
The generally accepted view is that the 3,4,5-trimethoxy-substituted aromatic A-ring of combretastatin A-4 (CA-4) and its analogues should be conserved in order to maintain biological activity through enforcing an active molecular conformation. Contrary to this, we have found that substituting the larger meta-methoxy groups of CA-4 with smaller halogen atoms results in compounds that are equipotent or more potent than CA-4 itself in vitro.
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