☆ 4.3 Article

2013 White Paper on recent issues in bioanalysis: 'hybrid' - the best of LBA and LCMS

BIOANALYSIS (2013)

期刊

BIOANALYSIS

卷 5, 期 23, 页码 2903-2918

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FUTURE SCI LTD

DOI: 10.4155/bio.13.238

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Biochemical Research Methods Chemistry, Analytical

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US FDA
Europe EMA
Health Canada
Netherlands MEB
Brazil ANVISA
Japan MHLW
UK MHRA

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The 2013 7th Workshop on Recent Issues in Bioanalysis was held in Long Beach, California, USA, where close to 500 professionals from pharmaceutical and biopharmaceutical companies, CROs and regulatory agencies convened to discuss current topics of interest in bioanalysis. These hot' topics, which covered both small and large molecules, were the starting point for fruitful exchanges of knowledge, and sharing of ideas among speakers, panelists and attendees. The discussions led to specific recommendations pertinent to bioanalytical science. Such as the previous editions, this 2013 White Paper addresses important bioanalytical issues and provides practical answers to the topics presented, discussed and agreed upon by the global bioanalytical community attending the 7th Workshop on Recent Issues in Bioanalysis.

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Article Chemistry, Medicinal

Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

Esther Torrente, Valentina Fodale, Alina Ciammaichella, Federica Ferrigno, Jesus M. Ontoria, Simona Ponzi, Ilaria Rossetti, Alessio Sferrazza, Jerome Amaudrut, Antonino Missineo, Simone Esposito, Simone Palombo, Martina Nibbio, Mauro Cerretani, Monica Bisbocci, Antonella Cellucci, Annalise di Marco, Cristina Alli, Vincenzo Pucci, Carlo Toniatti, Alessia Petrocchi

Summary: Protein tyrosine phosphatase SHP2 acts as an oncogenic protein by regulating various cytokine receptors and receptor tyrosine kinase signaling pathways. Here, we present a new series of SHP2 allosteric inhibitors with an imidazopyrazine 6,5-fused heterocyclic system as the central scaffold, which exhibit strong enzymatic and cellular potency. Compound 8, a highly potent SHP2 allosteric inhibitor, was identified through structure-activity relationship studies, showing novel stabilizing interactions compared to known SHP2 inhibitors. Further optimization led to the discovery of analogue 10, which demonstrates excellent potency and promising pharmacokinetic properties in rodents.

ACS MEDICINAL CHEMISTRY LETTERS (2023)

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Article Chemistry, Medicinal

Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

Esther Torrente, Valentina Fodale, Alina Ciammaichella, Federica Ferrigno, Jesus M. Ontoria, Simona Ponzi, Ilaria Rossetti, Alessio Sferrazza, Jerome Amaudrut, Antonino Missineo, Simone Esposito, Simone Palombo, Martina Nibbio, Mauro Cerretani, Monica Bisbocci, Antonella Cellucci, Annalise di Marco, Cristina Alli, Vincenzo Pucci, Carlo Toniatti, Alessia Petrocchi

Summary: Protein tyrosine phosphatase SHP2 is an oncogenic protein that regulates multiple signaling pathways. This study identified a new series of SHP2 allosteric inhibitors with a central scaffold of imidazopyrazine 6,5-fused heterocyclic system, showing good potency in enzyme and cellular assays. Compound 8, a highly potent SHP2 allosteric inhibitor, was identified through SAR studies and X-ray analyses revealed novel stabilizing interactions. Further optimization led to the discovery of analogue 10, which exhibits excellent potency and promising pharmacokinetic profile in rodents.

ACS MEDICINAL CHEMISTRY LETTERS (2023)

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Article Oncology

Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

Yun Wang, Long Cui, Peter Georgiev, Latika Singh, Yanyan Zheng, Ying Yu, Jeff Grein, Chunsheng Zhang, Eric S. Muise, David L. Sloman, Heidi Ferguson, Hongshi Yu, Cristina St. Pierre, Pranal J. Dakle, Vincenzo Pucci, James Baker, Andrey Loboda, Doug Linn, Christopher Brynczka, Doug Wilson, Brian B. Haines, Brian Long, Richard Wnek, Svetlana Sadekova, Michael Rosenzweig, Andrew Haidle, Yongxin Han, Sheila H. Ranganath

Summary: The study demonstrates that the EP4 inhibitor MF-766 synergizes with anti-PD-1 therapy to enhance anti-tumor activity by modulating infiltration profiles of myeloid cells, NK cells, cDCs, and T-cells in the tumor microenvironment (TME).

ONCOIMMUNOLOGY (2021)

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