Identifying metabolite ions of peptide drugs in the presence of an in vivo matrix background

Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification

(2011) Charles B Reilly et al.   Proteome Science

Chemical Modifications Designed to Improve Peptide Stability: Incorporation of Non-Natural Amino Acids, Pseudo-Peptide Bonds, and Cyclization

(2010) Luca Gentilucci et al.   CURRENT PHARMACEUTICAL DESIGN

A novel strategy for the targeted analysis of protein and peptide metabolites

(2010) Nicholas A. Williamson et al.   PROTEOMICS

An Accurate-Mass-Based Spectral-Averaging Isotope-Pattern-Filtering Algorithm for Extraction of Drug Metabolites Possessing a Distinct Isotope Pattern from LC-MS Data

(2009) Peijuan Zhu et al.   ANALYTICAL CHEMISTRY

The Medicinal Chemistry of Peptides

(2009) J. Nestor Jr.   CURRENT MEDICINAL CHEMISTRY

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry

(2009) Haiying Zhang et al.   JOURNAL OF MASS SPECTROMETRY

Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters

(2009) Russell J. Mortishire-Smith et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Biomolecular structural separations by ion mobility–mass spectrometry

(2008) Larissa S. Fenn et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration

(2008) Filip Cuyckens et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY