期刊
BIOANALYSIS
卷 4, 期 17, 页码 2153-2159出版社
FUTURE SCI LTD
DOI: 10.4155/BIO.12.189
关键词
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资金
- Technologie Servier (Orleans, France)
- French Ministry of Health PHRC (France)
- France Alzheimer Patients Association
- ANR CholAD (French-Canadian Cooperation)
Background: Lipidomic studies related to Alzheimer's disease have been reported on either biological fluids or large human brain samples. For a better understanding of the role of lipids, especially during the amyloid-P peptide aggregation, it is crucial to determine the composition of the senile plaque versus the surrounding tissue, that is, the neuropil. Results: A laser microdissection step was added to the analysis by UPLC-MS/MS. Despite the very low amount of sample, two phosphatidylcholines that were significantly depleted in the senile plaque were identified. Conclusion: Changes in the phospholipid content have been shown between senile plaque versus neuropil. Nano HPLC, allowing a complete lipidomic profile, should further improve the results.
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