Article
Chemistry, Analytical
Lanyu Liu, Qian Liu, Yan Wang, Yu Yuan, Feifan Xie
Summary: This study aimed to evaluate different combinations of polyanion-metal ion based solution system for phospholipids removal and elimination of matrix effects in human plasma. The optimized ZrOCl2-Ludox/DSS systems provided efficient phospholipids removal and adequate analyte recovery, and they also correctly eliminated ion suppression or enhancement of the non-polar and polar drugs.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Chui-Wei Wong, Kun-Che Tsai, Lok Kumar Shrestha, Katsuhiko Ariga, Shan-hui Hsu
Summary: This study reported the preparation and investigation of water-dispersible self-assembled fullerenes. The results showed that chemically etched hydrophilic fullerene nanotubes (FNTs) were endocytosed by neural stem cells (NSCs) and induced their neural differentiation. The size, shape, and surface functional groups of fullerenes also played a role in NSCs differentiation.
Article
Environmental Sciences
Manfei Lin, Jian Zhen Yu
Summary: The study reveals that oxidative potential (OP) in inhaled ambient fine particulate matter (PM2.5) is mainly caused by transition metals (TMs) and humic-like substances (HULIS), with water-soluble copper (Cu) in Hong Kong samples leading to higher OP than in Beijing samples. Cu is a dominant contributor to hydroxyl radical formation and ascorbic acid depletion, despite higher levels of water-soluble iron (Fe) present.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemical Research Methods
El zbieta Gniazdowska, Joanna Giebultowicz, Piotr J. Rudzki
Summary: Mass spectrometry coupled with liquid chromatography is a valuable tool for drug development and personalised drug therapy. The matrix effect is caused by enhancing or suppressing the analyte signal intensity by the interfering compounds of biological fluids. The matrix effect may influence the reliability of the quantitative results, thus its evaluation is critical in bioanalytical method validation.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Chemistry, Analytical
Yu Wang, Zhigang Hao, Long Pan
Summary: The study developed a chromatographic method for quantifying arginine as a biomarker in saliva, solving key issues of peak shape optimization and surrogate matrix methodology replacement for traditional methods. The method achieved detection and quantification limits of 2 and 6 ng/mL with a tailing factor within the 0.9-1.1 range.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Engineering, Chemical
Xu Ye, Jiayang Jin, Caiyan Liang, Jiahui Wang, Lihua Jiang, Liming Zhao
Summary: This study investigates the effects of phospholipids (PLs) on the bloom formation in chocolate. Model systems with different concentrations of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) were designed. The results show that the addition of PLs significantly retards the bloom formation in chocolate, especially in the PE and PS systems. The reduction in bloom is attributed to the improved microstructural stability and reduced particle interactions and crystallization.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Chemistry, Applied
Peizhen Li, Rongmao Lu, Jie Zhu, Qingqing Ke, Dingnan Wang, Yang Wang, Chen Zhang, Xinyue Lu, Miaolong Zhao, Zhang Wang, Lingling Pan, Meiling Zhang, Jun Ying, Shiyan Li
Summary: A sensitive and reliable ultra-performance hydrophilic interaction chromatography-tandem mass spectrometry method was developed to determine paralytic shellfish toxins (PSTs) and tetrodotoxin (TTX) in marine shellfish. The method involved the use of a HILIC-Z column for chromatographic separation and a porous carbon solid-phase extraction for sample clean-up. The calibration curves for PSTs and TTX were linear, with good sensitivity and low limits of detection and quantitation. The method was successfully applied to determine PSTs and TTX in three batches of Nassarius, showing excellent accuracy.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Chemistry, Analytical
Huaxu Yu, Ying Chen, Tao Huan
Summary: This study explores how experimental factors contribute to computational variation in untargeted metabolomics, proposing a quality control sample-based correction workflow to minimize this variation. The bioinformatic solution is successfully demonstrated in a metabolomic comparison of leukemia patients before and after chemotherapy, showing significant changes in metabolic features.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Kate Porter, John K. Lodge
Summary: This study developed a HILIC-MS method for the analysis of water-soluble vitamins, using a vegetable soup matrix for extraction and determining the content of four B vitamins. The method showed excellent linearity, reproducibility, and applicability to other plant-based food matrices.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Physical
Clifford Morris, Thomas W. Kent, Fengyun Shen, Ewa P. Wojcikiewicz, Deguo Du
Summary: The mutations of the N-terminal charged residues of A beta(40) significantly affect the peptide-induced membrane leakage, and the flexible and charge-rich N-terminal region may play a critical role in directing A beta self-association on the membrane surface and stabilizing the peptide aggregates.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Engineering, Mechanical
Zhongshu Ren, M. Javad Javaherian, Christine M. Gilbert
Summary: This study investigated the specific process and effects of hydroelastic slamming by vertically dropping a V-shaped wedge model with a 20-degree deadrise angle into calm water. It was found that the maximum deflection and strain occurred in the chine-unwetted phase of the wedge model. The kinematic effect of hydroelasticity altered spray root propagation, while the inertial effect increased the natural period of the plate.
JOURNAL OF FLUIDS AND STRUCTURES
(2021)
Article
Agriculture, Multidisciplinary
Xibin Liao, Yihui Chen, Meikang Lei, Chunyan Hou, Xie Li, Tingting Wang
Summary: A new method for simultaneous determination of carbadox and olaquindox in animal feeds was developed, which showed high efficiency and stability. The method increased the adsorption capacity of the particles under hydrophilic-interaction conditions.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Haiyan Liu, Pingping Bing, Meijun Zhang, Geng Tian, Jun Ma, Haigang Li, Meihua Bao, Kunhui He, Jianjun He, Binsheng He, Jialiang Yang
Summary: In this study, a novel method called MNNMDA was proposed to predict microbe-disease associations by applying a Matrix Nuclear Norm method. The method constructed a heterogeneous information network by calculating Gaussian interaction profile kernel and functional similarity for diseases and microbes. The microbe-disease association prediction problem was formulated as a low-rank matrix completion problem, and the effectiveness of MNNMDA was validated through experiments on multiple datasets.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Cell Biology
Pratap Karki, Chen-Ou Zhang, Kamoltip Promnares, Yue Li, Yunbo Ke, Anna A. Birukova, Konstantin G. Birukov
Summary: Oxidized phospholipids (OxPLs) are present in the circulation at basal levels, but during microbial infections, sepsis, and trauma, there is a significant increase in OxPLs accompanied by changes in composition. Truncated oxidized phospholipids (Tr-OxPLs) have detrimental effects on pulmonary endothelium, but their role in modulating lung injury caused by bacterial pathogens is not yet clear.
CELLULAR SIGNALLING
(2023)
Article
Environmental Sciences
Shuai Zhang, Bijiao Wang, Limin Zhang, Suzanne Lacasse, Farrokh Nadim, Yunmin Chen
Summary: This paper proposes an improved framework for quantifying the human risk caused by cascading hazards and illustrates it with a multi-hazard example close to the epicenter of the Wenchuan earthquake.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)