Article
Cell Biology
Junfeng Su, Fengwen Huang, Yu Tian, Ran Tian, Qianqian Gao, Stephen Temitayo Bello, Dingxaun Zeng, Peter Jendrichovsky, C. Geoffrey Lau, Wenjun Xiong, Daiguan Yu, Micky Tortorella, Xi Chen, Jufang He
Summary: This study reveals the critical role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus, affecting CA3-CA1 LTP and space-related performance.
Article
Neurosciences
Harsha Gurnani, R. Angus Silver
Summary: Inhibitory neurons, specifically cerebellar Golgi cells (GoCs), exhibit multidimensional activity patterns that could be utilized for inhibition-mediated adaptive gain control and spatiotemporal patterning. The activity of GoCs is organized into multiple modes during spontaneous behaviors, with a slow, network-wide modulation correlating with whisking and locomotion, and faster differential population activity encoding more precise information. Modeling these circuits demonstrated the importance of electrical coupling for maintaining these population activity patterns.
Article
Clinical Neurology
Valeria de Almeida, Gabriela Seabra, Guilherme Reis-de-Oliveira, Giuliana S. Zuccoli, Priscila Rumin, Mariana Fioramonte, Bradley J. Smith, Antonio W. Zuardi, Jaime E. C. Hallak, Alline C. Campos, Jose A. Crippa, Daniel Martins-de-Souza
Summary: Cannabinoid signaling affects pathways related to cell proliferation, migration, and differentiation in oligodendrocytes, as well as modulates carbohydrate and lipid metabolism and mitochondrial function.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Ana Bernal-Chico, Vanja Tepavcevic, Andrea Manterola, Carmen Utrilla, Carlos Matute, Susana Mato
Summary: This review summarizes the current understanding of the role and clinical relevance of endocannabinoid signaling in glial cells, as well as its therapeutic potential in neurodegenerative and chronic inflammatory disorders.
Article
Biochemistry & Molecular Biology
Marta Baranowska-Kuczko, Hanna Kozlowska, Monika Kloza, Ewa Harasim-Symbor, Michal Biernacki, Irena Kasacka, Barbara Malinowska
Summary: Our study found that hypertension and chronic administration of the FAAH inhibitor URB597 have beneficial effects on the vascular endocannabinoid system in SHR, suggesting potential therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Olivier Le Bacquer, Kassandra Lanchais, Kristell Combe, Loic Van Den Berghe, Stephane Walrand
Summary: Sarcopenia, age-related muscle loss, is associated with changes in skeletal muscle protein homeostasis, which may be regulated by the endocannabinoid system. The CB1 receptor antagonist rimonabant stimulates protein synthesis independently of CB1, suggesting potential for treating sarcopenia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Andrew J. Kesner, David M. Lovinger
Summary: Cannabis sativa is the most widely used illicit drug in the world, with its main psychoactive component being THC. Despite its medical therapeutic qualities, frequent cannabis or THC users may develop cannabis use disorder, exhibiting classical addiction symptoms. Effective treatments for cannabis use disorder and withdrawal symptoms are currently lacking, highlighting the importance of research on the neurobiological mechanisms underlying these syndromes.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Vanessa De Giacomo, Sabine Ruehle, Beat Lutz, Martin Haering, Floortje Remmers
Summary: Several studies have shown that the CB1 receptor plays a crucial role in exploratory behavior, with distinct effects in forebrain GABAergic and dorsal telencephalic glutamatergic neurons. Reactivating CB1 receptor signaling in glutamatergic neurons enhanced exploratory behavior, while reactivating in GABAergic neurons reduced it. The effects weakened with increasing environmental familiarity, indicating a causal role for altered neophobia in these phenotypes.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Adam Ponzi, Salvador Dura-Bernal, Michele Migliore
Summary: Oscillations are a common feature of brain operations and are found across different animal species. These oscillations appear in discrete frequencies and are coupled, with the phase of one oscillation modulating the amplitude of another. However, the biophysical origin and reasons for the ubiquity of these oscillations remain unclear. Using a data-driven computational model, researchers demonstrate how a basic microcircuit can generate phase-amplitude coupled oscillations, suggesting a general underlying mechanism.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Neurosciences
Tibor M. Brunt, Matthijs G. Bossong
Summary: The endocannabinoid system is a complex neuronal system involved in various biological functions, and its understanding has been driven by the potential therapeutic benefits of cannabinoid ligands. This review provides an overview of the neuropharmacology of cannabinoid receptor ligands, including endocannabinoids, herbal cannabis, and synthetic cannabinoids, focusing on their modulatory actions through other neurotransmitter systems. The effects of cannabinoid ligands on neurotransmitter systems such as dopamine, serotonin, glutamate, noradrenaline, opioid, and GABA are discussed, as well as their therapeutic potential and adverse effects.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
An Liu, Ling Lin, Wei Xu, Zhihua Gong, Zhonghua Liu, Wenjun Xiao
Summary: l-Theanine competitively binds to cannabinoid receptor 1 to regulate immune function and glutamine metabolism. In normal rats, it inhibits ERK1/2 phosphorylation to affect GS expression, while in stressed rats it decreases TNF-alpha expression and increases IL-10 expression.
Article
Multidisciplinary Sciences
Meirigeng Qi, John S. Kaddis, Kuan-Tsen Chen, Jeffrey Rawson, Keiko Omori, Zhen Bouman Chen, Sangeeta Dhawan, Jeffrey S. Isenberg, Fouad Kandeel, Bart O. Roep, Ismail H. Al-Abdullah
Summary: Chronic marijuana use has been found to affect the endocrine phenotype and function of human pancreatic islets, as well as the reversal rate of diabetes in transplantation studies. Islets from marijuana-users displayed reduced insulin secretion and enhanced CB1R expression in beta cells.
Article
Pharmacology & Pharmacy
Stewart Ramsay, Nick J. Spencer, Vladimir Zagorodnyuk
Summary: The aim of this study is to determine the role of endocannabinoids, anandamide (AEA) and 2-arachidonolylglycerol (2-AG), in regulating mechanosensitivity of probable nociceptive neurons innervating the bladder - capsaicin-sensitive mucosal afferents. The results showed that AEA potentiated the mechanical response of mucosal afferents, while 2-AG inhibited their response. These findings have important implications for understanding the role of endocannabinoids in regulating bladder sensation and function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laurel Watkins de Jong, Mohammadreza Mohagheghi Nejad, Euisik Yoon, Sen Cheng, Kamran Diba
Summary: Recurrent connectivity and feedback inhibition from inhibitory neurons play crucial roles in determining the dynamics and computational properties of neuronal circuits. Through optogenetic manipulations and large-scale unit recordings, paradoxical responses were observed in both CA1 and CA3 regions of the hippocampus, where subsets of cells increased firing during photoinhibition while others decreased firing during photoexcitation. These paradoxical responses were more prominent in CA3 and simulations confirmed that both CA1 and CA3 hippocampal regions exhibit inhibition-stabilized networks with strong recurrent excitation.
Article
Neurosciences
Sheila A. Engi, Erin J. Beebe, Victoria M. Ayvazian, Fabio C. Cruz, Joseph F. Cheer, Jennifer M. Wenzel, Natalie E. Zlebnik
Summary: Mesolimbic dopamine plays a crucial role in motivated behavior, with CB1 receptor signaling in the VTA being implicated in the phasic activation of dopamine. Cocaine-induced increases in motivation appear to require 2-AG signaling at CB1 receptors in the VTA, suggesting potential cannabinoid-based pharmacotherapeutic targets for substance abuse treatment.
Article
Multidisciplinary Sciences
Serafim Rodrigues, Mathieu Desroches, Martin Krupa, Jesus M. Cortes, Terrence J. Sejnowski, Afia B. Ali
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Pharmacology & Pharmacy
Archie A. Khan, Tawfeeq Shekh-Ahmad, Ayatakin Khalil, Matthew C. Walker, Afia B. Ali
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Martin W. Nicholson, Aaron Sweeney, Eva Pekle, Sabina Alam, Afia B. Ali, Michael Duchen, Jasmina N. Jovanovic
MOLECULAR PSYCHIATRY
(2018)
Article
Neurosciences
Afia B. Ali
CURRENT NEUROPHARMACOLOGY
(2009)
Article
Neurosciences
A. B. Ali, M. Todorova
EUROPEAN JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Afia B. Ali
JOURNAL OF NEUROPHYSIOLOGY
(2011)
Article
Neurosciences
Claire L. De-May, Afia B. Ali
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Neurosciences
Darren Goffin, Afia B. Ali, Nazir Rampersaud, Alexander Harkavyi, Celine Fuchs, Peter S. Whitton, Angus C. Nairn, Jasmina N. Jovanovic
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
C. L. De-May, A. B. Ali
Article
Neurosciences
Alexandra L. Petrache, Aarib Rajulawalla, Anqi Shi, Andrea Wetzel, Takashi Saito, Takaomi C. Saido, Kirsten Harvey, Afia B. Ali
Article
Neurosciences
Anqi Shi, Alexandra L. Petrache, Jiachen Shi, Afia B. Ali
Review
Clinical Neurology
Afia B. Ali, Anam Islam, Andrew Constanti
Summary: Alzheimer's disease is a common neurological disorder characterized by memory loss and abnormal brain activity. Synaptic hyperactivity may be caused by an imbalance in phasic and tonic synaptic inhibition regulated by the GABA(A) inhibitory system and the perineuronal nets (PNNs) in the brain regions. This review summarizes the vulnerability of different types of interneurons, changes in GABA(A) receptor subtypes, and alterations in PNNs in Alzheimer's disease, highlighting their contribution to the disease mechanisms.
Article
Neurosciences
Alexandra L. Petrache, Archie A. Khan, Martin W. Nicholson, Alessandra Monaco, Martyna Kuta-Siejkowska, Shozeb Haider, Stephen Hilton, Jasmina N. Jovanovic, Afia B. Ali
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Neurosciences
Afia B. Ali, Alex M. Thomson