Article
Behavioral Sciences
Anne Albrecht, Elisa Redavide, Stav Regev-Tsur, Oliver Stork, Gal Richter-Levin
Summary: Studies show that the hippocampal formation plays a crucial role in cognition, emotion, and adaptation to stressful events. Different types of inhibitory interneurons in the hippocampus have distinct roles in anxiety, fear, and stress adaptation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Maithe Loisy, Guillaume Bouisset, Sebastien Lopez, Maud Muller, Alena Spitsyn, Jeanne Duval, Rebecca Ann Piskorowski, Laure Verret, Vivien Chevaleyre
Summary: This study reveals a novel inhibitory plasticity mediated by cannabinoid type 1 receptor activation (CB1R-iLTD) in the CA2 region of the hippocampus, which plays a crucial role in social memory formation. The study also demonstrates that the previous induction of Delta-opioid receptor-mediated long-term depression (DOR-iLTDs) is necessary for the CB1R-iLTD to occur. The findings provide insights into the interplay between inhibitory plasticities and a new mechanism for social memory formation.
Article
Neurosciences
Antonio Figueiredo, Joseph F. Cheer
Summary: In the past few decades, significant research has been devoted to understanding the effects of cannabinoids on learning and memory, both endogenous and exogenous. This review focuses on the impact of cannabinoid signaling on episodic or hippocampus-dependent memory, primarily using pharmacological approaches. It provides an overview of the endocannabinoid system, mechanisms of memory formation, and discusses the effects of cannabinoids on memory encoding, consolidation, retrieval, extinction, synaptic plasticity, and intracellular signaling within the hippocampus.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Rashad Yusifov, Anja Tippmann, Jochen F. Staiger, Oliver M. Schlueter, Siegrid Loewel
Summary: Key periods in brain development, known as Critical periods, are crucial for synaptic connection refinement. A protein called PSD-95 plays a major role in the maturation of synapses. Impaired PSD-95 function affects spine dynamics, leading to altered structural plasticity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Fangchen Zhu, Sarah Elnozahy, Jennifer Lawlor, Kishore V. Kuchibhotla
Summary: The study found that cholinergic signals from the basal forebrain relay auditory information to the auditory cortex. These signals are modulated by brain and behavioral states and provide repeated auditory representations across the cortical tonotopy. However, it remains unknown whether sensory cholinergic signals target the sensory cortex and how they relate to local functional topography.
NATURE NEUROSCIENCE
(2023)
Article
Biochemical Research Methods
Toviah Moldwin, Menachem Kalmenson, Idan Segev
Summary: This study explores the importance and application potential of synaptic clustering on neuronal dendrites in pattern recognition, proposing two models - single-branch clusteron and gradient clusteron - which utilize structural plasticity and functional plasticity to solve classification tasks. Experimental results demonstrate that the gradient clusteron achieves decent accuracy on the MNIST dataset tasks.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Neurosciences
Vivien Miczan, Krisztina Kelemen, Judit R. Glavinics, Zsofia Laszlo, Benjamin Barti, Kata Kenesei, Mate Kisfali, Istvan Katona
Summary: The molecular repertoire of calcium-binding proteins in Ca2+ signaling pathways plays a crucial role in meeting the specific kinetic requirements of Ca2+-dependent processes in different types of neurons. By investigating CB1/CCK-positive interneurons, it was revealed that NECAB1 and NECAB2 are predominant calcium-binding proteins in this cell type, showing functional differences at the subcellular nanoscale level.
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Behavioral Sciences
Yuki Kajita, Hajime Mushiake
Summary: This study compared GAD65 expression among six GABAergic subtypes, revealing high-expression and low-expression groups in the cerebral cortex and hippocampus. Different GABAergic subtypes exhibit distinct GAD65 expression patterns in the layers of the cerebral cortex and hippocampus, with GAD65 expression in the soma serving as a proxy for cytoplasmic GAD65 levels.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Martin Field, Istvan P. Lukacs, Emily Hunter, Richard Stacey, Puneet Plaha, Laurent Livermore, Olaf Ansorge, Peter Somogyi
Summary: The study found that specific types of interneurons in the human neocortex, such as rosehip cells and layer 2-3 innervating cells, exhibit larger tonic GABA(A) receptor currents compared to other interneuron types, potentially allowing for selective modulation of cortical circuitry. Patient parameters like age, seizures, cancer type, and anticonvulsant treatment were also examined for their potential influence on tonic inhibitory currents in human neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Luca Pancotti, Lisa Topolnik
Summary: This article reviews the evidence regarding the modulatory effects of acetylcholine (ACh) on dendritic computations in three subtypes of hippocampal interneurons: fast-spiking parvalbumin-positive (PV+) cells, somatostatin-expressing (SOM+) oriens lacunosum moleculare cells, and vasoactive intestinal polypeptide-expressing (VIP+) interneuron-selective interneurons. The distribution and actions of cholinergic receptors on these interneurons are discussed, along with the potential modulation of dendritic Ca2+ signaling and neuronal activity. The article suggests that cholinergic modulation can shape dendritic integration and plasticity in interneurons in a cell type-specific manner, which is important for understanding their contribution to large-scale network activity.
Article
Anatomy & Morphology
Milan Aksic, Joko Poleksic, Dubravka Aleksic, Natasa Petronijevic, Nevena V. Radonjic, Maja Jakovcevski, Slobodan Kapor, Nevena Divac, Branislav R. Filipovic, Igor Jakovcevski
Summary: Early life stress, specifically maternal deprivation, led to decreased numbers of certain interneuron subpopulations in the hippocampus and prefrontal cortex of rats, indicating complex and region-specific alterations in inhibitory circuitry. Decreased inhibitory synapses were also observed in the hippocampus of exposed rats, which may contribute to behavioral manifestations and potential mechanisms underlying neuropsychiatric disorders like schizophrenia.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Behavioral Sciences
Kirstie A. Cummings, Anthony F. Lacagnina, Roger L. Clem
Summary: Recent studies suggest that while excitatory projection neurons (PNs) play a critical role in memory functions, their activity during learning and recall is extensively regulated by a diverse array of GABAergic interneurons (INs). These findings highlight the importance of investigating the role of interneurons in fear memory networks.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Neurosciences
Jiuyang Ding, Jian Huang, Xiang Tang, Lingyi Shen, Shanshan Hu, Jiaojiao He, Ting Liu, Zhixing Yu, Yubo Liu, Qiyan Wang, Jiawen Wang, Na Zhao, Xiaolan Qi, Jiang Huang
Summary: This study found that low dose METH promotes synaptic formation and increases synaptic number, enhancing memory function; while high dose METH leads to synaptic degeneration, neuronal loss, and memory impairment. In addition, high dose METH also causes gliosis. Mechanistically, low dose METH activates Cdc42 and inactivates Rac1, while high dose METH inactivates Cdc42 and activates Rac1.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Cindy Brunskine, Stefan Passlick, Christian Henneberger
Summary: The concept of the tripartite synapse describes the close interaction between pre- and postsynaptic elements and the surrounding astrocyte processes. This study used super-resolution expansion microscopy to examine the organization of GABAergic synapses and nearby astrocytic processes. The findings indicate that astrocytic processes are less abundant near GABAergic synapses compared to glutamatergic synapses, and are more abundant at GABAergic synapses with large postsynaptic gephyrin clusters. These observations provide insights into the organization and function of synapses.
Article
Neurosciences
Thomas Stefanelli, Cristina Bertollini, Christian Luescher, Dominique Muller, Pablo Mendez
Article
Cell Biology
Pablo Mendez, Thomas Stefanelli, Carmen E. Flores, Dominique Muller, Christian Luscher
Article
Neurosciences
Bernadett Boda, Pablo Mendez, Benjamin Boury-Jamot, Fulvio Magara, Dominique Muller
EUROPEAN JOURNAL OF NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Irina Nikonenko, Alexander Nikonenko, Pablo Mendez, Tatyana V. Michurina, Grigori Enikolopov, Dominique Muller
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Multidisciplinary Sciences
Carmen E. Flores, Irina Nikonenko, Pablo Mendez, Jean-Marc Fritschy, Shiva K. Tyagarajan, Dominique Muller
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Neurosciences
Wei Zhang, Maria Ciorraga, Pablo Mendez, Diana Retana, Norah Boumedine-Guignon, Beatriz Achon, Michael Russier, Dominique Debanne, Juan Jose Garrido
Summary: The axon initial segment (AIS) is crucial for neuronal function, with the actin and microtubule cytoskeleton playing a key role in regulating AIS structure and function, and formins playing a critical role in maintaining AIS composition and stability.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
M. Estrella Fernandez de Sevilla, Jaime Pignatelli, Jonathan A. Zegarra-Valdivia, Pablo Mendez, Angel Nunez, Ignacio Torres Aleman
Summary: This study reveals that mice lacking functional insulin-like growth factor I (IGF-I) receptors in orexin neurons exhibit PTSD-like behavior and are unresponsive to the anxiolytic effects of IGF-I, while inhibition of orexin neurons improves this behavior. Systemic IGF-I treatment also ameliorates PTSD-like behavior in mice, and IGF-I modulates the GABA/Glutamate synaptic structure in orexin neurons to achieve this effect.
MOLECULAR PSYCHIATRY
(2022)
Article
Biology
Andres De la Rossa, Marine H. Laporte, Simone Astori, Thomas Marissal, Sylvie Montessuit, Preethi Sheshadri, Eva Ramos-Fernandez, Pablo Mendez, Abbas Khani, Charles Quairiaux, Eric B. Taylor, Jared Rutter, Jose Manuel Nunes, Alan Carleton, Michael R. Duchen, Carmen Sandi, Jean-Claude Martinou
Summary: Neuronal excitation relies on ATP from oxidative phosphorylation, and deficient oxidative phosphorylation can lead to hyperexcitability in neurons. Inhibiting GABA activity in mice with deficient mitochondrial pyruvate carrier (MPC) led to seizures and death, but providing ketone bodies restored energy and attenuated seizures. These findings provide insights into epilepsy and other neuropathologies associated with energy deficits.
Article
Neurosciences
Tomas E. Sachella, Marina R. Ihidoype, Christophe D. Proulx, Diego E. Pafundo, Jorge H. Medina, Pablo Mendez, Joaquin Piriz
Summary: Fear is a pathological condition that can be studied using fear conditioning, which is the best-understood model of fear learning. This study investigates the role of the lateral habenula in fear conditioning and finds that it is involved in the formation of independent contextual and cued fear memories.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Alicia Hernandez-Vivanco, Nuria Cano-Adamuz, Alberto Sanchez-Aguilera, Alba Gonzalez-Alonso, Alberto Rodriguez-Fernandez, Inigo Azcoitia, Liset Menendez de la Prida, Pablo Mendez
Summary: Using a combination of molecular, genetic, functional and behavioural tools, this study describes the impact of brain synthesized estrogen on inhibitory neuronal function, network oscillations and hippocampal dependent memory.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Fani Koukouli, Martin Montmerle, Andrea Aguirre, Marcel De Brito Van Velze, Jeremy Peixoto, Vikash Choudhary, Marjorie Varilh, Francisca Julio-Kalajzic, Camille Allene, Pablo Mendez, Yann Zerlaut, Giovanni Marsicano, Oliver M. Schluter, Nelson Rebola, Alberto Bacci, Joana Lourenco
Summary: The perisomatic inhibition of pyramidal neurons is controlled by CB1 receptors, and this mechanism is different in various visual areas, impacting neuronal activity patterns.
Article
Biochemistry & Molecular Biology
E. P. Moreno-Jimenez, M. Flor-Garcia, A. Hernandez-Vivanco, J. Terreros-Roncal, C. B. Rodriguez-Moreno, N. Toni, P. Mendez, Maria Llorens-Martin
Summary: Adult hippocampal neurogenesis enhances brain plasticity and contributes to the cognitive reserve during aging. The molecular mechanisms regulating the maturation and synaptic integration of new neurons are not fully understood. In this study, the formation and maturation of inhibitory synapses during adult hippocampal neurogenesis were investigated using a novel retrovirus. The results suggest that GSK-3β plays a key role in inhibitory synapse formation and maturation during adult hippocampal neurogenesis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Luis M. Garcia-Segura, Pablo Mendez, M. Angeles Arevalo, Inigo Azcoitia
Summary: The brain synthesizes various neurosteroids, including neuroestradiol, which have effects on neurodevelopmental processes. The synthesis of neuroestradiol influences neurogenesis, neuroblast migration, neuritogenesis, and synaptogenesis. Some of the effects of neuroestradiol are sex-specific, and the X linked gene regulation may determine the sex-specific actions of neuroestradiol in the female brain.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Alicia Hernandez-Vivanco, Esther Jimenez-Redondo, Nuria Cano-Adamuz, Pablo Mendez
Summary: This study reveals that protein kinase A (PKA) induces long-term potentiation (iLTP) at inhibitory synapses in hippocampal granule cells (GCs), specifically those formed by local INs expressing somatostatin (SST). This PKA-dependent inhibitory synapse plasticity selectively modifies local inhibitory microcircuits essential for hippocampal function.
