Article
Multidisciplinary Sciences
Timothy Monko, Jaclyn Rebertus, Jeff Stolley, Stephen R. Salton, Yasushi Nakagawa
Summary: Extrinsic cues from sensory thalamic projections play an early role in the formation of cortical cytoarchitecture by enhancing the production and specification of layer 4 neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Hong Li, Alvaro Duque, Pasko Rakic
Summary: New studies in rodents have provided insights into the functions of the claustrum, suggesting its involvement in attention, salience detection, slow-wave generation, and neocortical network synchronization. However, the origin and development of the claustrum, particularly in primates, remain poorly understood. This study demonstrates that the claustrum in rhesus macaque embryos expresses neocortical molecular markers and undergoes two waves of neurogenesis, establishing a core and shell cytoarchitecture. Furthermore, the claustrum is found to be an independent pallial region, indicating its potentially unique role in cognitive control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Susanne Schoch, Anne Quatraccioni, Barbara K. Robens, Robert Maresch, Karen M. J. van Loo, Silvia Cases-Cunillera, Tony Kelly, Thoralf Opitz, Valeri Borger, Dirk Dietrich, Julika Pitsch, Heinz Beck, Albert J. Becker
Summary: SLK plays a critical role in the development of cortical neurons in mice, specifically in the elaboration of higher dendrites and maintaining the balance between excitation and inhibition. Knockdown of SLK leads to loss of inhibitory synapses and functional inhibition in mouse neurons, with potential relevance to human cortical malformations.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Vera Valakh, Derek Wise, Xiaoyue Aelita Zhu, Mingqi Sha, Jaidyn Fok, Stephen D. Van Hooser, Robin Schectman, Isabel Cepeda, Ryan Kirk, Sean M. O'Toole, Sacha B. Nelson
Summary: Healthy neuronal networks require homeostatic plasticity to maintain stable firing rates. However, inappropriate or excessive activation of these mechanisms can lead to destabilization and rebound hyperactivity. In this study, the negative regulation of cortical network homeostasis by the PARbZIP family of transcription factors was uncovered. Knockout mice lacking these factors showed a stronger network response to activity withdrawal, indicating their critical role in constraining plasticity and preventing seizures.
Article
Biochemistry & Molecular Biology
Chu-Yi Zhang, Xiao Xiao, Zhuohua Zhang, Zhonghua Hu, Ming Li
Summary: Transcriptomic and long-read sequencing analyses have revealed alternative splicing characteristics of schizophrenia risk genes, identifying new spliced isoforms and providing examples for investigating these isoforms in vitro and in vivo.
MOLECULAR PSYCHIATRY
(2022)
Letter
Clinical Neurology
Juri-Alexander Witt, Albert J. Becker, Christoph Helmstaedter
Summary: In response to the review by Zawar and Kapur, we highlight the bidirectionality between epilepsy and dementia, summarize the multifactorial etiology of cognitive deficits in epilepsy, emphasize the prevalent neuropathological findings in MTLE, and state the potential adverse effects of anti-seizure medication on cognition. We conclude that the neuropsychology and neuropathology of MTLE is more complex than suggested in the review, and further studies are needed to explore the role of hyperphosphorylated tau in epilepsy patients with and without AD.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Sandra E. Parker, Mark C. Bellingham, Trent M. Woodruff
Summary: The brain is now known to have intimate connections with the immune system, particularly through the complement system. Complement activation plays crucial roles in neurodevelopment and synaptic plasticity in the adult brain. Dysregulation of complement-mediated synaptic remodeling can lead to severe dysfunction in various neurological disorders. Understanding the physiological role of complement in the brain is especially important due to the increasing use of complement-targeted therapeutics in clinical trials.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shutaro Katsurabayashi, Kohei Oyabu, Kaori Kubota, Takuya Watanabe, Tomohisa Nagamatsu, Norio Akaike, Katsunori Iwasaki
Summary: The study found that TND1128 can promote morphological growth of mouse hippocampal neurons, increase the number of excitatory synapses, and provide a new drug treatment approach for improving brain function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Tamas Papp, Zsuzsanna Ferenczi, Bernadette Szilagyi, Matyas Petro, Angelika Varga, Eva Kokai, Ervin Berenyi, Gabor Olah, Gabor Halmos, Peter Szucs, Zoltan Meszar
Summary: The regulation of neuronal differentiation and synaptogenesis requires precise coordination of intrinsic and extrinsic factors. While ultrasound is known to acutely alter neuronal migration and activity, its chronic effect on neuronal behavior or morphology is not well understood. This study investigated the neurobiological effects of high-frequency ultrasound on cortical pyramidal cell morphology in a transgenic mouse model, finding that low-intensity ultrasound stimulation led to increased dendritic branching and activation of certain signaling pathways.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Bokyung Song, Chong-Hyun Kim
Summary: The PLC81 null mouse model shows enhanced neurogenesis in the DG of the hippocampus, along with increased moving activity and seizures. The results suggest that PLC81 plays a cell-autonomous inhibitory role in the proliferation of adult neural stem/progenitor cells in vivo and the excitability of DG granule cells.
NEUROSCIENCE LETTERS
(2022)
Article
Biology
Emily L. Heckman, Chris Q. Doe
Summary: The organization of neural circuits is crucial for nervous system function. In this study, the authors investigate how dendrites of interneurons detect and match variation in presynaptic partner location and input strength. They find that presynaptic contact stimulates dendrite outgrowth locally, while presynaptic activity inhibits postsynaptic dendrite outgrowth globally. These mechanisms are active during an early larval critical period for structural plasticity. The findings provide new insights into dendrite development and mechanisms that allow dendrites to respond flexibly to developmental variability in presynaptic inputs.
Article
Biology
Lisa A. E. Catsburg, Manon Westra, Annemarie M. L. van Schaik, Harold D. MacGillavry
Summary: This study reveals the dynamic organization of the clathrin-coated structure at postsynaptic sites and its role in synaptic plasticity. The endocytic zone (EZ) acts as a stable and highly organized molecular platform, where different components are recruited and positioned to regulate the endocytosis of synaptic receptors.
Article
Neurosciences
Tadashi Nomura, Hitoshi Gotoh, Hiroshi Kiyonari, Katsuhiko Ono
Summary: Temporal control of neurogenesis is crucial for the development and evolution of brain structures. The balance between progenitor expansion and neuronal differentiation is tightly coordinated by cell-intrinsic and cell-extrinsic cues. Wnt signaling plays a key role in the proliferation and differentiation of neural progenitors, but the regulatory mechanisms adjusting intracellular signaling amplitudes are not fully understood.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Ricardo Martins-Ferreira, Barbara Leal, Joao Chaves, Tianlu Li, Laura Ciudad, Rui Rangel, Agostinho Santos, Antonio Martins da Silva, Paulo Pinho Costa, Esteban Ballestar
Summary: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common focal epilepsy in adults, characterized by high rates of drug resistance. Epileptogenesis in MTLE-HS is associated with epigenetic alterations, with previous studies mainly focused on the hippocampus. This study examines DNA methylation profiles in both the hippocampus and anterior temporal neocortex of MTLE-HS patients, showing altered DNA methylation patterns in multiple pathways related to epileptogenesis. The neocortex, which has less histopathological damage, also shows significant DNA methylation changes, suggesting its involvement in epilepsy development. These findings suggest a progressive wave of epigenetic dysregulation associated with inflammation-related genes in MTLE-HS.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Maxime Veleanu, Beetsi Urrieta-Chavez, Severine M. Sigoillot, Maela A. Paul, Alessia Usardi, Keerthana Iyer, Marine Delagrange, Joseph P. Doyle, Nathaniel Heintz, Carine Becamel, Fekrije Selimi
Summary: Environmental perturbations during early life can contribute to psychiatric diseases. This study focuses on the impact of neonatal subchronic administration of the drug PCP on the cerebellum, discovering specific changes in Purkinje cell connectivity and the overexpression of the Ctgf gene, which has been suggested as a biomarker for schizophrenia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Fatma El-Zahraa A. El-Gamal, Mohammed M. Elmogy, Mohammed Ghazal, Ahmed Atwan, Manuel F. Casanova, Gregory N. Barnes, Ayman S. El-Baz, Hassan Hajjdiab
FRONTIERS IN BIOSCIENCE-LANDMARK
(2018)
Article
Neurosciences
Fatma E. A. El-Gamal, Mohammed M. Elmogy, Mohammed Ghazal, Ahmed Atwan, Manuel F. Casanova, Gregory N. Barnes, Robert Keynton, Ayman S. El-Baz, Ashraf Khalil
FRONTIERS IN HUMAN NEUROSCIENCE
(2018)
Article
Neurosciences
Jiannan Kang, Erjuan Cai, Junxia Han, Zhen Tong, Xin Li, Estate M. Sokhadze, Manuel F. Casanova, Gaoxiang Ouyang, Xiaoli Li
FRONTIERS IN NEUROSCIENCE
(2018)
Letter
Neurosciences
Eleanor J. Cole, Peter G. Enticott, Lindsay M. Oberman, M. Frampton Gwynette, Manuel F. Casanova, Scott L. J. Jackson, Ali Jannati, James C. McPartland, Adam J. Naples, Nicolaas A. J. Puts
BIOLOGICAL PSYCHIATRY
(2019)
Review
Neurosciences
Manuel F. Casanova, Emily L. Casanova
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Behavioral Sciences
Emily L. Casanova, Andrew E. Switala, Srini Dandamudi, Allison R. Hickman, Joshua Vandenbrink, Julia L. Sharp, Frank Alex Feltus, Manuel F. Casanova
Article
Biochemistry & Molecular Biology
Emily L. Casanova, Miriam K. Konkel
Review
Health Care Sciences & Services
Emily L. Casanova, Carolina Baeza-Velasco, Caroline B. Buchanan, Manuel F. Casanova
JOURNAL OF PERSONALIZED MEDICINE
(2020)
Article
Genetics & Heredity
Nattaporn Tassanakijpanich, Forrest J. McKenzie, Yingratana A. McLennan, Elisabeth Makhoul, Flora Tassone, Mittal J. Jasoliya, Christopher Romney, Ignacio Cortina Petrasic, Kaye Napalinga, Caroline B. Buchanan, Paul Hagerman, Randi Hagerman, Emily L. Casanova
Summary: This study reported five cases of FMR1 premutation carriers with hypermobile Ehlers-Danlos syndrome (hEDS) phenotype, indicating that premutation may lead to reduced fragile X mental retardation protein and RNA toxicity, which co-occur with hEDS due to commonalities in pathogenesis.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Social Sciences, Interdisciplinary
Emily L. Casanova, Cheryl J. Widman
Summary: The Medical Model focuses on diagnosed conditions, the Social Model sees disability as imposed by attitudes and barriers in society, and the Neurodiversity Model believes differences in brain and behavior exist on a non-pathological spectrum. The models have different impacts on policymaking and practice, hence the proposal of the Biological Gradient Model to address issues of partial representation.
Article
Psychology, Clinical
Manuel F. Casanova, Mohamed Shaban, Mohammed Ghazal, Ayman S. El-Baz, Emily L. Casanova, Estate M. Sokhadze
Summary: Research suggests that low frequency TMS targeting the DLPFC can normalize gamma oscillation abnormalities in high functioning ASD individuals. After TMS treatment, significant changes in gamma oscillations were observed in autistic subjects, indicating that the ringing decay of gamma oscillations may serve as a potential outcome measure for interventions in autism.
APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
(2021)
Article
Psychology, Multidisciplinary
Emily L. Casanova, Julia L. Sharp, Stephen M. Edelson, Desmond P. Kelly, Manuel F. Casanova
BEHAVIORAL SCIENCES
(2018)
Article
Neurosciences
Estate M. Sokhadze, Eva V. Lamina, Emily L. Casanova, Desmond P. Kelly, Ioan Opris, Allan Tasman, Manuel F. Casanova
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2018)