Article
Neurosciences
Yun Fei Feng, Yin Yong Zhou, Kai Ming Duan
Summary: Postpartum depression is a serious disease that has a high incidence and severe impact on pregnant women and infants. However, the mechanism of this condition is still unclear. Recent studies have shown that GABA receptors, especially extrasynaptic receptors, are closely associated with postpartum depression. This review focuses on the function of GABA receptors, particularly extrasynaptic receptors, and their association with postpartum depression.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Dmitri A. Rusakov, Michael G. Stewart
Summary: The behavior of mammals relies on excitatory circuits in the brain equipped with glutamatergic synapses, and the spatial relationship between these synapses and perisynaptic astroglial processes is crucial in understanding glutamate signaling actions. The organization of synaptic micro-physiology and micro-environment plays a critical part in how glutamate can escape the synaptic cleft to activate target receptors outside the immediate synapse. Neuronal activity- and astroglia-dependent glutamate spillover actions are increasingly recognized as important across various cognitive functions.
Article
Multidisciplinary Sciences
Vikram Babu Kasaragod, Martin Mortensen, Steven W. Hardwick, Ayla A. Wahid, Valentina Dorovykh, Dimitri Y. Chirgadze, Trevor G. Smart, Paul S. Miller
Summary: Type A GABA receptors are a diverse population in the mammalian brain, and mutations in these receptors are linked to epilepsy and insomnia. Altered function of extrasynaptic receptors is implicated in insomnia, stroke, and certain syndromes. This study investigates the structures of the predominantly extrasynaptic alpha beta GABA(A) receptor class and explains their distinct features related to tonic signaling.
Article
Biochemistry & Molecular Biology
Yangning Lu, Tosif Ahamed, Ben Mulcahy, Jun Meng, Daniel Witvliet, Sihui Asuka Guan, Douglas Holmyard, Wesley Hung, Quan Wen, Andrew D. Chisholm, Aravinthan D. T. Samuel, Mei Zhen
Summary: In C. elegans, the motor circuit of juvenile stage generates adult-like bending waves with dorsal-ventral symmetry, despite having asymmetric wiring between motor neurons and muscles. This is achieved through the coordination between excitatory and inhibitory motor neurons for dorsal muscle contraction and ventral muscle relaxation, respectively.
Article
Neurosciences
Marcin Wyroslak, Katarzyna Lebida, Jerzy W. Mozrzymas
Summary: The study examined the plasticity of tonic inhibition in hippocampal pyramidal neurons under NMDAR-dependent GABAergic inhibitory long-term potentiation (iLTP) induction protocol. It was found that alpha 5-containing GABA(A)Rs played a key role in mediating the plastic change in tonic current during this process.
Article
Plant Sciences
Nasiara Karim, Imran Khan, Abeer Abdelhalim, Sobia Ahsan Halim, Ajmal Khan, Ahmed Al-Harrasi
Summary: The study showed that stigmasterol is a potential candidate for the treatment of neurological disorders by modulating GABA receptors, which can alleviate anxiety and seizure symptoms.
Article
Clinical Neurology
Lynne M. Bird, Cesar Ochoa-Lubinoff, Wen-Hann Tan, Gali Heimer, Raun D. Melmed, Amit Rakhit, Jeannie Visootsak, Matthew J. During, Christina Holcroft, Rebecca D. Burdine, Alexander Kolevzon, Ronald L. Thibert
Summary: This study evaluated the safety, tolerability, and exploratory efficacy of Gaboxadol in individuals with Angelman syndrome. Gaboxadol was found to be generally well-tolerated and showed some efficacy in improving symptoms, warranting further studies.
Review
Neurosciences
Xianshu Bai, Frank Kirchhoff, Anja Scheller
Summary: This review focuses on the role of GABA as the main inhibitory neurotransmitter in the CNS, particularly in the oligodendrocyte lineage. It discusses the physiological functions of GABA receptors within this lineage and their potential as targets for treatments of CNS diseases.
NEUROSCIENCE BULLETIN
(2021)
Review
Neurosciences
Ayla Arslan
Summary: GABA(A) receptors play a key role in inhibiting the adult brain, with specific subtypes like the delta-subunit-GABA(A) receptors expressed in areas like the hippocampus. These receptors, containing the delta subunit, have integrative roles in network oscillations, adding complexity to the understanding of their functions.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Faouzi Zarrouki, Sebastien Goutal, Ophelie Vacca, Luis Garcia, Nicolas Tournier, Aurelie Goyenvalle, Cyrille Vaillend
Summary: This study found that the loss of dystrophin in a mouse model of Duchenne muscular dystrophy (DMD) affects not only the stability of synaptic GABA(A) receptors, but also the composition and expression of subunits at both synaptic and extrasynaptic sites. These findings provide new measures to evaluate compensation for nervous system alterations in DMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Ulf Roland, Frank Holzer, Frank-Dieter Kopinke
Summary: This study investigated the reductive catalytic conversion of DDT under ambient conditions using platinum and palladium supported on porous alumina and silica. The results showed that almost complete hydrodechlorination and hydrogenation of DDT occurred, leading to the formation of diphenylethane and dicyclohexylethane. The long-range reactivity was observed even when DDT and the metal component were deposited on separate particles and mechanically mixed. The fast diffusion of target compounds was identified as the dominant mechanism for the observed long-range reactivity.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Behavioral Sciences
Gabriele Floris, Gino Paolo Asuni, Giuseppe Talani, Francesca Biggio, Maria Giuseppina Pisu, Mary Tresa Zanda, Liliana Contu, Elisabetta Maciocco, Mariangela Serra, Paolo Follesa
Summary: This study investigates the role of the GABA(B)R receptor in alcohol consumption and preference in mice. The results show that mice lacking functional GABA(B)R drink more alcohol, prefer alcohol over water, and have higher blood alcohol concentrations compared to wild-type mice. Additionally, the study suggests that the GABA(B)R receptor modulates the activity of GABA(A) receptors in the hippocampus, potentially influencing alcohol preference in mice.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychiatry
Ting Xiang, Jiwu Liao, Yixian Cai, Mei Fan, Congrui Li, Xiaotao Zhang, Hongyao Li, Yushan Chen, Jiyang Pan
Summary: The study aimed to investigate the changes in various indexes of the GABAergic system in the peripheral blood of patients with insomnia disorder and identify related factors. The results showed that the mRNA levels of GABA(A) receptor alpha 1 and alpha 2 subunits were significantly lower in the insomnia disorder group compared to the normal control group. However, there was no significant difference in serum GABA levels between the two groups. Moreover, there was no significant correlation between the GABA levels and the mRNA expression levels of alpha 1 and alpha 2 subunits of GABA(A) receptors in the insomnia disorder group.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Cell Biology
Sina Hafizi, Tarek K. Rajji
Summary: This review proposes a conceptual model that links 12 potentially modifiable risk factors for dementia with Excitation-Inhibition (E -I) imbalance. The model aims to address the current knowledge gap and provides a framework for future studies in dementia prevention, discovery of new biomarkers, and development of new interventions.
AGEING RESEARCH REVIEWS
(2023)
Article
Cell Biology
Leonid P. Savtchenko, Dmitri A. Rusakov
Summary: Once released outside the synaptic cleft, the neurotransmitter glutamate binds quickly to its transporters on astroglial cells, limiting its excitatory transmission within synapses. However, there is growing evidence for glutamate's extrasynaptic actions, although the mechanisms and scope of these actions are still unclear. Our simulations support the concept of significant volume-transmitted actions of glutamate in the brain, with the unbinding of glutamate transporters playing an important role.
Article
Biochemistry & Molecular Biology
Jens-Peter David, Ulrike Lisewski, Shawn M. Crump, Thomas A. Jepps, Elke Bocksteins, Nicola Wilck, Janine Lossie, Torsten K. Roepke, Nicole Schmitt, Geoffrey W. Abbott
Editorial Material
Neurosciences
Jean-Francois Perrier
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Biochemistry & Molecular Biology
Christian Paludan-Muller, Jonas Ghouse, Oliver B. Vad, Cecilie B. Herfelt, Pia Lundegaard, Gustav Ahlberg, Nicole Schmitt, Jesper H. Svendsen, Stig Haunso, Henning Bundgaard, Torben Hansen, Jurgen K. Kanters, Morten S. Olesen
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Neurosciences
Eva Maria Meier Carlsen, Dipak Amrutkar, Karin Sandager-Nielsen, Jean-Francois Perrier
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Sofia Hammami Bomholtz, Marwan Refaat, Annette Buur Steffensen, Jens-Peter David, Karin Espinosa, Robert Nussbaum, Julianne Wojciak, Bo Hjorth Bentzen, Melvin Scheinman, Nicole Schmitt
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Thea Hyttel Hansen, Yannan Yan, Gustav Ahlberg, Oliver Bundgaard Vad, Lena Refsgaard, Joana Larupa dos Santos, Nancy Mutsaers, Jesper Hastrup Svendsen, Morten Sailing Olesen, Bo Hjorth Bentzen, Nicole Schmitt
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Joana Larupa Santos, Ismael Rodriguez, Morten S. Olesen, Bo Hjorth Bentzen, Nicole Schmitt
Article
Neurosciences
Eva Maria Meier Carlsen, Sarah Falk, Urszula Skupio, Laurie Robin, Antonio C. Pagano Zottola, Giovanni Marsicano, Jean-Francois Perrier
Summary: The study demonstrates that cannabinoids reduce tremor associated with motor disorders by acting on cannabinoid receptors on astrocytes in the spinal cord, ultimately inhibiting excitatory synaptic transmission and decreasing tremor.
NATURE NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Oliver Bundgaard Vad, Yannan Yan, Federico Denti, Gustav Ahlberg, Lena Refsgaard, Sofia Hammami Bomholtz, Joana Larupa Santos, Simon Rasmussen, Stig Haunso, Jesper Hastrup Svendsen, Ingrid Elizabeth Christophersen, Nicole Schmitt, Morten Salling Olesen, Bo Hjorth Bentzen
Summary: AF is a common sustained cardiac arrhythmia with complex pathogenesis, and rare genetic variants in the CACNA1A gene have been identified in patients with familial AF, suggesting a potential novel link between ion channel dysfunction and increased risk of AF.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Julian A. Schreiber, Melina Moeller, Mark Zaydman, Lu Zhao, Zachary Beller, Sebastian Becker, Nadine Ritter, Panpan Hou, Jingyi Shi, Jon Silva, Eva Wrobel, Nathalie Strutz-Seebohm, Niels Decher, Nicole Schmitt, Sven G. Meuth, Martina Duefer, Bernhard Wuensch, Jianmin Cui, Guiscard Seebohm
Summary: Loss-of-function mutations in K(v)7.1 can lead to long QT syndrome, and the benzodiazepine derivative (R)-L3 shows potential as a treatment strategy by modulating channel dynamics to shorten action potential duration. The molecular mechanisms of (R)-L3 modulation include allosteric effects on the pore domain and alterations in kinetics independent of pore domain effects.
COMMUNICATIONS BIOLOGY
(2022)
Article
Physics, Applied
James L. Webb, Luca Troise, Nikolaj W. Hansen, Louise F. Frellsen, Christian Osterkamp, Fedor Jelezko, Steffen Jankuhn, Jan Meijer, Kirstine Berg-Sorensen, Jean-Francois Perrier, Alexander Huck, Ulrik Lund Andersen
Summary: This study demonstrates a method utilizing point defects in solid-state materials to achieve high-resolution measurement of signals in microscopic circuits, enabling simultaneous spatial and temporal recovery.
PHYSICAL REVIEW APPLIED
(2022)
Article
Neurosciences
Alexia Montalant, Ole Kiehn, Jean-Francois Perrier
Summary: Spinal cord astrocytes respond to dopamine and noradrenaline with compartmentalized calcium responses that start in endfeet. Dopamine induces localized responses, while noradrenaline triggers stronger, spreading responses. These findings expand our understanding of astrocyte-neurotransmitter interactions and their roles in central nervous system physiology.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Meeting Abstract
Physiology
N. Schmitt
Review
Physiology
Alexia Montalant, Eva M. M. Carlsen, Jean-Francois Perrier
Summary: Neurotransmitters released from neurons bind to receptors expressed by astrocytes, leading to an increase in calcium concentration and the release of gliotransmitters that eventually modulate synaptic transmission. It is likely that astrocytes impact motor control through the activation of this pathway.
PHYSIOLOGICAL REPORTS
(2021)
Article
Neurosciences
Annika H. Runegaard, Andreas T. Sorensen, Ciaran M. Fitzpatrick, Soren H. Jorgensen, Anders V. Petersen, Nikolaj W. Hansen, Pia Weikop, Jesper T. Andreasen, Jens D. Mikkelsen, Jean-Francois Perrier, David Woldbye, Mattias Rickhag, Gitta Wortwein, Ulrik Gether