Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator

A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning

(2013) Adriana del Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice

(2013) Chia-Wen Lin et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains

(2013) Chia-Wen Lin et al.   Innate Immunity

Induction of Thermal Hyperalgesia and Synaptic Long-Term Potentiation in the Spinal Cord Lamina I by TNF-  and IL-1  is Mediated by Glial Cells

(2013) D. Gruber-Schoffnegger et al.   JOURNAL OF NEUROSCIENCE

The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model

(2013) Hui-Ching Lin et al.   PLoS One

Long Lasting Protein Synthesis- and Activity-Dependent Spine Shrinkage and Elimination after Synaptic Depression

(2013) Yazmín Ramiro-Cortés et al.   PLoS One

SHANK1 Deletions in Males with Autism Spectrum Disorder

(2012) Daisuke Sato et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prenatal exposure to valproic acid enhances synaptic plasticity in the medial prefrontal cortex and fear memories

(2012) Li Sui et al.   BRAIN RESEARCH BULLETIN

Cortactin-Binding Protein 2 Modulates the Mobility of Cortactin and Regulates Dendritic Spine Formation and Maintenance

(2012) Y.-K. Chen et al.   JOURNAL OF NEUROSCIENCE

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

(2012) Michael J. Schmeisser et al.   NATURE

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice

(2012) Kim Nuytens et al.   NEUROBIOLOGY OF DISEASE

Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening

(2012) Won Chan Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

(2011) Chiara Verpelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

(2011) Chiung-Ya Chen et al.   JOURNAL OF CELL BIOLOGY

Valosin-containing protein and neurofibromin interact to regulate dendritic spine density

(2011) Hsiao-Fang Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Extracellular Signal-Regulated Kinase in Synaptic Transmission and Plasticity of a Nociceptive Input on Capsular Central Amygdaloid Neurons in Normal and Acid-Induced Muscle Pain Mice

(2011) S.-J. Cheng et al.   JOURNAL OF NEUROSCIENCE

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Targeted Deletion of CASK-Interacting Nucleosome Assembly Protein Causes Higher Locomotor and Exploratory Activities

(2011) Wen-Chuan Chung et al.   NEUROSIGNALS

Bidirectional synaptic plasticity induced by conditioned stimulations with different number of pulse at hippocampal CA1 synapses: Roles ofN-methyl-D-aspartate and metabotropic glutamate receptors

(2011) Jui-Cheng Hsu et al.   SYNAPSE

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation

(2010) Simone Berkel et al.   NATURE GENETICS

The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Involvement of Ca2+/calmodulin kinase II (CaMK II) in genistein-induced potentiation of leucine/glutamine-stimulated insulin secretion

(2009) Soo-Jin Lee et al.   MOLECULES AND CELLS

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

(2008) A. Y. Hung et al.   JOURNAL OF NEUROSCIENCE

Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression

(2008) Peter R. Moult et al.   JOURNAL OF PHYSIOLOGY-LONDON