Review
Neurosciences
Ying Luo, Songjie Liao, Jian Yu
Summary: In this review, the neuroprotective function of Netrin-1 and its possibly involved pathways after ischemic stroke are discussed, providing a basis for the development of novel treatments.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Cell Biology
Charlie Colin-Pierre, Nicolas Berthelemy, Nicolas Belloy, Louis Danoux, Vincent Bardey, Romain Rivet, Solene Mine, Christine Jeanmaire, Francois-Xavier Maquart, Laurent Ramont, Stephane Brezillon
Summary: The study indicates that GPC1 is a key regulator of microvascular endothelial cell angiogenesis induced by VEGF and HGF secreted by KORS. GPC1 may be an interesting target to tackle alopecia in dermatology research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ana Muniz-Garcia, Bettina Wilm, Patricia Murray, Michael J. Cross
Summary: This study shows that MSC-derived EVs can modulate VEGFR2 signaling and promote cell survival, leading to a positive effect on angiogenesis.
Article
Pharmacology & Pharmacy
Carlos Mateluna, Pedro Torres, Marcelo Rodriguez-Pena, Patricio Silva, Douglas J. Matthies, Alfredo Criollo, Floris J. Bikker, Jan G. M. Bolscher, Christian A. M. Wilson, Gerald Zapata-Torres, Vicente A. Torres
Summary: In this study, it was found that VEGFR2 is the endothelial cell receptor of Histatin-1, revealing the mechanism by which Histatin-1 promotes endothelial cell migration and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rong Ma, Qian Xie, Hongyan Li, Xiaoqing Guo, Jian Wang, Yong Li, Mihong Ren, Daoyin Gong, Tian Gao
Summary: L-borneol can improve neurological deficits, reduce cerebral infarction, and promote angiogenesis by increasing levels of Ang-1 and VEGF, while also promoting neurogenesis, as well as affecting the expression of VEGF, BDNF, TGF-beta 1, and MMP9 to play a neuroprotective role in cerebral ischemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Si Sun, Yitong Xu, Ningxi Yu, Meifeng Zhang, Jinghui Wang, Dong Wan, Zhen Tian, Huifeng Zhu
Summary: Stroke is a major cause of disability and death worldwide, but there is a lack of effective therapeutic strategies. This study showed that catalpol, a compound derived from Rehmannia glutinosa, protected against ischemic stroke by promoting angiogenesis and neural stem cell proliferation and differentiation. The protective effects of catalpol were mediated through VEGF-A/KDR pathway activation.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Plant Sciences
Pei Zhang, Suxin You, Xinyue Ding, Pengwei Luan, Jiazhen Xu, Qianfei Cui, Feiyun Wang, Ruixiang Li, Yuying Zhu, Jiange Zhang
Summary: Musk is a widely used traditional Chinese medicine with resuscitation, activating blood, and disperse swelling effects. This study aimed to investigate the effect and mechanism of muscone in improving ischemic stroke, and verified its efficacy in ischemia-reperfused rats, as well as investigated its mechanism using PC12 and THP-1 cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Jiale Gao, Mingjiang Yao, Dennis Chang, Jianxun Liu
Summary: Ischemic stroke is a leading cause of morbidity and disability globally. The body's limited repair capacity makes the sequelae of serious neurological damage irreversible. However, endogenous neurogenesis induced by cerebral ischemia plays a critical role in the repair and regeneration of impaired neural cells after ischemic brain injury.
Article
Clinical Neurology
Marc-Antoine Labeyrie, Fabiola Serrano, Vittorio Civelli, Clement Jourdaine, Peggy Reiner, Jean-Pierre Saint-Maurice, Hugues Chabriat, Emmanuel Houdart
Summary: The presence of carotid artery web may be considered as a potential source of large intracranial artery embolism, especially in patients with embolic stroke of undetermined source. Longitudinal studies are required to further investigate the risk of recurrence associated with these lesions.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Biology
Yeaji Kim, Dong Young Kim, Haiying Zhang, Cho-Rong Bae, Daehyeon Seong, Yeomyung Kim, Jaewhan Song, Young-Myeong Kim, Young-Guen Kwon
Summary: This study investigates the role of DIXDC1 in vasculature and its involvement in the crosstalk between VEGF/VEGFR2 and Wnt/beta-catenin signaling pathways. The results demonstrate that DIXDC1 is crucial in vascular development and pathological angiogenesis, acting as a mediator between the two signaling pathways.
Article
Biochemistry & Molecular Biology
Mauricio Muleiro Alvarez, Felipe Esparza Salazar, Thomas Rodriguez, Francesco D'Egidio, Cesar V. Borlongan, Jea-Young Lee
Summary: This study investigates the role of extracellular vesicles in endogenous repair within the neurovascular unit after ischemic stroke. The findings suggest that CD63 exosomes are spatially and temporally associated with glial activation, neurogenesis, and angiogenesis, indicating their potential contribution to the repair of the neurovascular unit.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Kahlilia C. Morris-Blanco, Anil K. Chokkalla, Mario J. Bertogliat, Raghu Vemuganti
Summary: The study demonstrates that TET3 plays a role in ischemic neuroprotection by regulating the levels of 5hmC at gene promoter regions, modulating multiple neuroprotective pathways, and potentially improving outcomes following ischemic injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Physiology
Zhihui Guo, Jia Jia, Yanling Tu, Chang Jin, Cen Guo, Feifei Song, Xuqing Wu, Haifeng Bao, Wei Fan
Summary: Our study revealed increased yet dysfunctional neovascularization with activated Jagged1-Notch1 signaling in the cerebrovasculature before cerebral ischemia in HFD/STZ rats, compared with non-diabetic rats. Furthermore, delayed angiogenesis and suppressed Jagged1-Notch1 signaling were observed after ischemic stroke in the same group of rats. This provides insight into the potential mechanisms underlying diabetes-related cerebral microvasculature dysfunction after ischemic stroke.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jasenka Guduric-Fuchs, Edoardo Pedrini, Judith Lechner, Sarah E. J. Chambers, Christina L. O'Neill, Joana Mendes Lopes de Melo, Varun Pathak, Rachel H. Church, Stuart McKeown, James Bojdo, Kiran J. Mcloughlin, Alan W. Stitt, Reinhold J. Medina
Summary: miR-130a acts as a mediator in the hypoxic response of ECFCs, enhancing their angiogenic and vasoreparative abilities by coordinating the upregulation of VEGFR2/STAT3/HIF1 alpha axis through translational inhibition of Ddx6.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biology
Che Mohd Nasril Che Mohd Nassir, Thenmoly Damodaran, Nurul Iman Ismail, Sabarisah Hashim, Usman Jaffer, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Anwar Norazit, Muzaimi Mustapha
Summary: In this review, the potential role of NLRP3 inflammasome activation in aging-related cerebral small vessel disease (CSVD) was explored. The current manifestations and complex pathogenesis of CSVD were discussed along with the involvement of NLRP3 inflammasome activation. These neuroinflammatory insights provide a deeper understanding of CSVD and highlight potential therapeutic targets.
Article
Cell Biology
Timo Schomann, Juvita D. Iljas, Ivo Que, Yuedan Li, Ernst Suidgeest, Luis J. Cruz, Johan H. M. Frijns, Alan Chan, Clemens M. W. G. Lowik, Margriet A. Huisman, Laura Mezzanotte
CELL AND TISSUE RESEARCH
(2020)
Review
Hematology
Sanny Scheffer, Dorien M. A. Hermkens, Louise van der Weerd, Helga E. de Vries, Mat J. A. P. Daemen
Summary: Alzheimer's disease is characterized by neurodegeneration, neuroinflammation, and cognitive decline. Cardiovascular disease has been identified as an important contributor to the development and progression of AD, known as the vascular hypothesis. Vascular risk factors are associated with an increased chance of developing AD, with chronic cerebral hypoperfusion suggested to play a key role in disease onset.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biology
Leon P. Munting, Marc Derieppe, Ernst Suidgeest, Lydiane Hirschler, Matthias Jp Van Osch, Baudouin Denis De Senneville, Louise Van der Weerd
Summary: In the Tg-SwDI mouse model, despite the presence of cerebral microvascular amyloid-b deposits, baseline perfusion and cerebrovascular reactivity estimates were similar compared to age-matched wild-type control mice, regardless of the modality (ASL or LDF) or anesthesia (isoflurane or urethane and a-chloralose). Hemodynamic changes were observed as an effect of age and anesthesia, raising questions about the representativeness of microvascular amyloidosis in Tg-SwDI mice for cerebrovascular dysfunction in CAA patients.
Article
Neurosciences
Jorge Miguel Amaya, Ernst Suidgeest, Isabelle Sahut-Barnola, Typhanie Dumontet, Nathanaelle Montanier, Guilhem Pages, Cecile Keller, Louise van der Weerd, Alberto M. Pereira, Antoine Martinez, Onno C. Meijer
Summary: Chronic exposure to high levels of glucocorticoids can have detrimental effects on health, leading to metabolic abnormalities such as those seen in Cushing's syndrome. MRI studies have shown volumetric changes in the brains of CS patients, both during active disease and in remission. Research in the AdKO mouse model for CS revealed brain region-specific changes, including aberrant myelination and white matter damage.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E. IJsselsteijn, Noel F. C. C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke M. C. van Roon-Mom, Thomas Hollt, Louise van der Weerd
Summary: Brain iron accumulation accelerates disease progression in Alzheimer patients with amyloid-beta. Activated microglia with increased iron accumulation influence the functional phenotype of cells, especially in conjunction with amyloid-beta. Spatial analysis showed that iron-accumulating microglia predominantly infiltrated A beta-plaques in the brain.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Clinical Neurology
Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Erik van Zwet, Paul C. de Kruijff, Thijs W. van Harten, Ellis S. van Etten, Sanneke van Rooden, Louise van der Weerd, Mark A. van Buchem, Matthias J. P. van Osch, Steven M. Greenberg, Marianne A. A. van Walderveen, Gisela M. Terwindt, Marieke J. H. Wermer
Summary: Cortical calcifications are common in Dutch-type hereditary CAA (D-CAA) but rare in sporadic CAA. These calcifications are associated with the development of intracerebral hemorrhage (ICH) and may serve as a marker for advanced CAA. Additionally, there seems to be a link between cortical calcifications on computed tomography and the striped occipital cortex on 7T-magnetic resonance imaging.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucia Bossoni, Ingrid Hegeman-Kleinn, Sjoerd G. van Duinen, Marjolein Bulk, Lena H. P. Vroegindeweij, Janneke G. Langendonk, Lydiane Hirschler, Andrew Webb, Louise Van der Weerd
Summary: The off-resonance saturation method was effective in detecting iron in gray matter structures in postmortem brain tissue, with iron concentrations obtained via this method shown to be in agreement with existing literature. This method can be used to study diseases characterized by brain iron accumulation and complement other iron-sensitive parametric methods.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neurosciences
Lena H. P. Vroegindeweij, Piotr A. Wielopolski, Agnita J. W. Boon, J. H. Paul Wilson, Rob M. Verdijk, Sipeng Zheng, Sylvestre Bonnet, Lucia Bossoni, Louise van der Weerd, Juan A. Hernandez-Tamames, Janneke G. Langendonk
Summary: The study validated R 2 * as a quantitative measure of brain iron content in aceruloplasminemia, showing a linear association between R 2 * and iron concentration, and high sensitivity to variations in iron concentration in severely iron-loaded brains.
Meeting Abstract
Clinical Neurology
M. Verhaeg, K. Adamzek, D. Van de Vijver, K. Putker, S. Engelbeen, E. Suidgeest, M. Overzier, L. van der Weerd, A. Aartsma-Rus, M. Putten
NEUROMUSCULAR DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Joanna Hummer, Thomas Birngruber, Frank Sinner, Leanne Page, Frank Toner, Clive S. Roper, David J. Moore, Mark B. Baker, Mila Boncheva Bettex
Summary: This paper presents a new approach to optimize topical products and select lead formulation candidates. The study compares the diffusion of diclofenac through all skin layers using open flow microperfusion and the Franz diffusion cell. The results demonstrate that the diffusion of diclofenac through the dermis and subcutis does not correlate with its diffusion through the skin barrier, and the Franz diffusion cell data alone cannot predict it. This approach provides a convenient tool for product development and selection.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Zhenfeng Yu, Yuanyuan He, Timo Schomann, Kefan Wu, Yang Hao, Ernst Suidgeest, Hong Zhang, Christina Eich, Luis J. Cruz
Summary: In this study, a novel type of rare-earth-doped nanoparticles (NPs) for multimodal imaging is synthesized and characterized. The NPs, composed of Ce, Gd, and Nd elements in a CaF2 host lattice, exhibit excellent optical properties and good biocompatibility. They can be used for in vivo fluorescence imaging, magnetic resonance imaging (MRI), and photoacoustic imaging (PAI), making them potential imaging agents in biomedical applications.
Article
Neuroimaging
Lena H. P. Vroegindeweij, Lucia Bossoni, Agnita J. W. Boon, J. H. Paul Wilson, Marjolein Bulk, Jacqueline Labra-Munoz, Martina Huber, Andrew Webb, Louise van der Weerd, Janneke G. Langendonk
Summary: Aceruloplasminemia is an ultra-rare neurodegenerative disorder characterized by massive brain iron deposits. The major iron form in aceruloplasminemia brain is ferrihydrite-iron, which drives iron-sensitive MRI contrast. The concentration of ferrihydrite-iron in the temporal cortex of patients is significantly higher compared to healthy controls, indicating its role in iron-related neurodegeneration.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Marjolein Bulk, Thijs van Harten, Boyd Kenkhuis, Francesca Inglese, Ingrid Hegeman, Sjoerd van Duinen, Ece Ercan, Cesar Magro-Checa, Jelle Goeman, Christian Mawrin, Mark van Buchem, Gerda Steup-Beekman, Tom Huizinga, Louise van der Weerd, Itamar Ronen
Summary: Neuroinflammation in NPSLE does not necessarily accompany iron accumulation, suggesting that the inflammatory pathomechanism in SLE may differ from neurodegenerative diseases and multiple sclerosis.
NEUROIMAGE-CLINICAL
(2021)