期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2013.00259
关键词
transcriptomics; cell death; amyotrophic lateral sclerosis; microarray
资金
- BBSRC
- European Union [259867]
- France, Agence Nationale dela Recherche(ANR)
- Germany, Bundesministerium fur Bildungund Forschung (BMBF)
- Ireland, Health Research Board (HRB)
- Italy, Ministero della Salute
- Netherlands, The Netherlands Organization forHealth Research and Development (ZonMw)
- Poland, Narodowe Centrum Badan iRozwoju
- Portugal, Fundacaoa CienciaeaTecnologia
- Spain, Ministeriode Cienciae Innovacion
- Switzerland, Schweizerischer National fonds zur Frderungder wissenschaftlichen Forschung (SNF)
- Turkey, Tubitak
- United Kingdom, Medical Research Council (MRC)
- Medical Research Council [MR/K000039/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10082] Funding Source: researchfish
- MRC [MR/K000039/1] Funding Source: UKRI
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by degeneration and loss of upper and lower motor neurons from the motor cortex, brainstem and spinal cord although evidence is suggesting that there is further involvement of other cell types in the surrounding tissue. Transcriptomic analysis by gene expression profiling using microarray technology has enabled the determination of patterns of cell death in the degenerating tissues. This work has examined gene expression at the level of the tissue and individual cell types in both sporadic and familial forms of the disease. In addition, further studies have examined the differential vulnerability of neuronal cells in different regions of the central nervous system. Model systems have also provided further information to help unravel the mechanisms that lead to death of the motor neurons in disease and also provided novel insights. In this review we shall describe the methods that have been used in these investigations and describe how they have contributed to our knowledge of the cell death mechanisms in ALS.
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