Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Yan Hao, Ya-juan Zhu, Song Zou, Pei Zhou, Ya-wen Hu, Qi-xiang Zhao, Lin-na Gu, Hao-zhou Zhang, Zhen Wang, Jiong Li
Summary: The association between psoriasis and metabolic syndrome involves various mechanisms including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels, and gut microbiota dysbiosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Jose E. Galgani, Rodrigo Fernandez-Verdejo
Summary: Glucose, fatty acids, and amino acids are oxidized to produce ATP for energy, and the complex adaptive systems in the body adjust fuel oxidation rates based on fuel availability. Metabolic flexibility refers to the ability of cells, tissues, or organisms to adapt fuel oxidation to fuel availability, which can be impaired in conditions like insulin resistance, diabetes, and obesity. Mitochondrial dysfunction in these conditions has been linked to metabolic inflexibility and overall metabolic health.
Review
Health Care Sciences & Services
George E. Zakynthinos, Vasiliki Tsolaki, Evangelos Oikonomou, Manolis Vavouranakis, Gerasimos Siasos, Epaminondas Zakynthinos
Summary: Metabolic syndrome and atrial fibrillation are closely related, as metabolic syndrome affects the left atrium in multiple ways, leading to the progression of atrial fibrillation. A holistic treatment approach can improve patient outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Jelena Nesic, Biljana Ljujic, Vesna Rosic, Aleksandar Djukic, Milenko Rosic, Ivica Petrovic, Nenad Zornic, Ivan P. Jovanovic, Sara Petrovic, Svetlana Djukic
Summary: Adiponectin and interleukin-33 are associated in patients with metabolic syndrome, with adiponectin potentially serving as an early marker and interleukin-33 being a potential predictor of inflammatory status in the early stage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Neurosciences
Marcin Gierach, Anna Rasmus, Edyta Orlowska
Summary: MetS patients performed worse in verbal fluency tests, possibly influenced by metabolic factors, especially in phonetic verbal fluency which is associated with the frontal cortex. Lower switching indicates possible executive dysfunctions, highlighting the need to focus on patients with MetS in therapy and improve their metabolic components to enhance cognitive function.
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lin-Nei Hsu, Ju-Chuan Hu, Po-Yen Chen, Wei-Chia Lee, Yao-Chi Chuang
Summary: This article discusses the interaction and common pathophysiological mechanisms between metabolic syndrome and overactive bladder. Understanding this association may help identify new diagnostic biomarkers and therapeutic targets.
Article
Biology
Zsofia Daradics, Cristian M. Crecan, Mirela A. Rus, Iancu A. Morar, Mircea V. Mircean, Adriana Florinela Catoi, Andra Diana Cecan, Cornel Catoi
Summary: Obesity is a serious health problem in human and animal populations, affecting cows and horses with conditions like Fat cow syndrome and Equine metabolic syndrome. These conditions, resembling Human metabolic syndrome in some aspects, require further research for better understanding and management.
Article
Medicine, General & Internal
Jose Ignacio Ramirez-Manent, Angel Arturo Lopez-Gonzalez, Pilar Tomas-Gil, Pere Riutord-Sbert, Lucia Garrido-Sepulveda, Maria Teofila Vicente-Herrero
Summary: This study examines the relationship between two obesity assessment methods based on hip circumference and metabolic syndrome (MetS) and insulin resistance risk scales. The results show that AVI demonstrates higher predictive value for MetS, while AVI and BAI mainly show predictive value for high insulin resistance risk scales in the case of METS-IR, with higher predictive value in women.
Review
Nutrition & Dietetics
Lucia Melguizo-Rodriguez, Victor J. Costela-Ruiz, Enrique Garcia-Recio, Elvira De Luna-Bertos, Concepcion Ruiz, Rebeca Illescas-Montes
Summary: The prevalence of hypovitaminosis D has been increasing in developed countries due to lifestyle changes and unhealthy habits. Scientific evidence shows an inverse relationship between vitamin D deficiency and metabolic syndrome (MetS), with supplementation helping improve outcomes in individuals with MetS. Maintaining optimal vitamin D concentrations is proposed as a preventive strategy against MetS.
Article
Endocrinology & Metabolism
Dilek Cicek, Nick Warr, Gozde Yesil, Hatice Kocak Eker, Firdevs Bas, Sukran Poyrazoglu, Feyza Darendeliler, Gul Direk, Nihal Hatipoglu, Mehmet Eltan, Zehra Yavas Abali, Busra Gurpinar Tosun, Sare Betul Kaygusuz, Tuba Seven Menevse, Didem Helvacioglu, Serap Turan, Abdullah Bereket, Richard Reeves, Michelle Simon, Matthew Mackenzie, Lydia Teboul, Andy Greenfield, Tulay Guran
Summary: Homozygous and heterozygous variants in the PPP2R3C gene are associated with syndromic gonadal dysgenesis, while loss of function of Ppp2r3c is not compatible with viability in mice and results in embryonic death.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Pediatrics
Ayse Pinar Ozturk, Asli Dudakli, Esin Karakilic Ozturan, Sukran Poyrazoglu, Firdevs Bas, Feyza Darendeliler
Summary: Osteogenesis imperfecta (OI) is a genetic disease characterized by fragile bones and variable short stature. In this retrospective cohort study, demographic data, clinical findings, growth and pubertal characteristics, and medical treatment of 83 OI patients were evaluated. The results showed that bisphosphonate therapy can improve bone mineral density and height in OI patients, but final adult height did not improve. Overweight and obesity were found to increase over time, and precocious and early puberty were common in OI patients. Effective interventions to improve mobility and functional parameters are necessary for these children.
KLINISCHE PADIATRIE
(2022)
Article
Endocrinology & Metabolism
Seha Saygili, Mehmet Kocaaga, Gamze Kaya, Mine Sukur, Firdevs Bas, Sukran Poyrazoglu, Ruveyde Bundak, Feyza Darendeliler
Summary: This study aimed to evaluate carotid intima-media thickness (cIMT) in children treated with recombinant human growth hormone (rhGH) and assess the effects of rhGH therapy on cIMT, as well as the changes in serum carbohydrate metabolism, lipid profile, and adipocytokines. The results showed that cIMT was increased in children treated with rhGH and it was associated with higher ghrelin levels and lower HDL levels. The alterations in carbohydrate metabolism were not associated with cIMT in children treated with rhGH.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ayse Pinar Ozturk, Zehra Yavas Abali, Ayca Dilruba Aslanger, Firdevs Bas, Gueven Toksoy, Volkan Karaman, Gulandam Bagirova, Sukran Poyrazoglu, Zehra Oya Uyguner, Feyza Darendeliler
Summary: This study aimed to examine the clinical and molecular characteristics of patients with IGHD/MPHD caused by GH1 gene variants. The findings provide insight into the genotype-phenotype correlation and the need for regular follow-up in these patients to monitor for additional pituitary hormone deficiencies.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Medicine, General & Internal
Zehra Yavas Abali, Firdevs Bas, Sukran Poyrazoglu, Ayse Pinar Ozturk, Ruveyde Bundak, Feyza Darendeliler
Summary: This study evaluated the clinical characteristics and treatment responses of children with chronic diseases, finding that they are at risk of inadequate bone mineralization. Dual-energy X-ray absorptiometry (DXA) was used to assess bone mineral density, and it was found that bisphosphonate treatment significantly improved bone density.
MEDICAL JOURNAL OF BAKIRKOY
(2023)
Article
Endocrinology & Metabolism
Zehra Yavas Abali, Ezgi Gokpinar Ili, Firdevs Bas, Melis Ulak Ozkan, Cagri Gulec, Guven Toksoy, Ayse Pinar Ozturk, Esin Karakilic Ozturan, Ayca Aslanger, Mine Caliskan, Gozde Yesil, Sukran Poyrazoglu, Feyza Darendeliler, Zehra Oya Uyguner
Summary: This study evaluates the clinical and molecular characteristics of two patients with congenital hypopituitarism and neuropathy. The patients showed developmental delay, intellectual disability, and deficiencies in thyroid hormones, growth hormone, and prolactin. MRI revealed pituitary hypoplasia. A novel pathogenic variant in the RNPC3 gene was detected in both patients.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Pediatrics
Basak Erginel, Banu Ozdemir, Meltem Karadeniz, Sukran Poyrazoglu, Erbug Keskin, Feryal Gun Soysal
Summary: The study aimed to evaluate the relationship between the age at surgery and the long-term outcomes of feminizing genitoplasty in patients with CAH. It was found that patients who underwent surgery before the age of 2 years required more additional surgeries and had lower satisfaction rates. Therefore, it is recommended to postpone surgery until the patient's gender identity matures and they can autonomously decide whether to undergo surgery.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Asli Derya Kardelen, Mine Sukur, Esin Karakilic Ozturan, Ayse Pinar Ozturk, Sukran Poyrazoglu, Firdevs Bas, Feyza Darendeliler
Summary: This study aimed to evaluate the auxological measurements and body proportions of Turner syndrome patients treated with recombinant human growth hormone (GH) and compare them with a group of healthy females. The results showed that TS patients had significantly shorter height, sitting height, and arm span, higher BMI, decreased extremity-trunk ratio, and shorter leg length compared to healthy controls. Despite GH treatment, TS patients still had disproportionate short stature.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Developmental Biology
Guilherme Guaragna-Filho, Gil Guerra-Junior, Rieko Tadokoro-Cuccaro, Ieuan A. Hughes, Beatriz A. Barros, Olaf Hiort, Antonio Balsamo, Tulay Guran, Paul M. Holterhus, Sabine Hannema, Sukran Poyrazoglu, Feyza Darendeliler, Jillian Bryce, S. Faisal Ahmed, Charmian A. Quigley
Summary: This study evaluated the practice of assigning female gender to 46, XY infants with limited virilization, particularly in the case of partial androgen insensitivity syndrome (PAIS). The results showed that female assignment is becoming less common in PAIS and there is no evidence to support prophylactic prepubertal gonadectomy in reducing the risk of germ cell tumor.
SEXUAL DEVELOPMENT
(2023)
Meeting Abstract
Endocrinology & Metabolism
Xanthippi Tseretopoulou, Salma R. Ali, Jillian Bryce, Atapattu Navoda, Niels H. Birkebaek, Federico Baronio, Walter Bonfig, Hedi L. Claahsen-van der Grinten, Martine Cools, Feyza Darendeliler, Sukran Poyrazoglu, Luisa de Sanctis, Heba Elsedfy, Martijn J. J. Finken, Christa E. Fluck, Evelien Gevers, Marta Korbonits, Tulay Guran, Ayla Guven, Ieuan A. Hughes, Rieko Tadokoro-Cuccaro, Ajay Thankamony, Violeta Iotova, Ruth Krone, Corina Lichiardopol, Berenice B. Mendonca, Tania A. S. S. Bachega, Mirela C. Miranda, Tatjana Milenkovic, Klaus Mohnike, Anna Nordenstrom, Hetty J. van der Kamp, Syed Faisal Ahmed
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Neil R. Lawrence, Irina Bacila, Jeremy Dawson, Salma R. Ali, Erica L. T. van den Akker, Tania Aparecida Sartori Sanchez Bachega, Federico Baronio, Niels Holtum Birkebaek, Walter Bonfig, Claahsen van der Grinten, Martine Cools, Eduardo Correa Costa, Liat de Vries, Christa Fluck, Gabriella Gazdagh, Ayla Guven, Sabine Hannema, Violeta Iotova, Hetty J. van der Kamp, Ruth Krone, Sofia Leka-Emiri, Maria Clemente Leon, Corina Raducanu Lichiardopol, Renata L. Markosyan, Tatjana Milenkovic, Mirela Costa de Miranda, Uta Neumann, John Newell-Price, Sukran Poyrazoglu, Ursina Probst-Scheidegger, Gianni Russo, Luisa De Sanctis, Adam Safwaan, Sumudu Seneviratne, Marianna Rita Stancampiano, Rieko Tadokoro-Cuccaro, Ajay Thankamony, Ana Vieites, Malgorzata Wasniewska, Diego Yeste, Eleni Daniel, Jeremy Tomlinson, S. Faisal Ahmed, Nils Krone
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ayse Pinar Ozturk, Ayca Aslanger, Esin Karakilic Ozturan, Esma Nur Konur, Cagri Gulec, Volkan Karaman, Melek Yildiz, Gozde Yesil, Guven Toksoy, Sukran Poyrazoglu, Firdevs Bas, Birsen Karaman, Zehra Oya Uyguner, Seher Basaran, Feyza Darendeliler
HORMONE RESEARCH IN PAEDIATRICS
(2022)
