Review
Immunology
Di Wu, Anna Cline-Smith, Elena Shashkova, Ajit Perla, Aditya Katyal, Rajeev Aurora
Summary: Osteoporosis, a common metabolic bone disease, particularly affects middle-aged and elderly women. Menopause is a leading cause of primary osteoporosis in women, and there is a growing recognition of the role of the adaptive immune system in the development of postmenopausal osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Lifei Liu, Yu Yuan, Shihua Zhang, Jiake Xu, Jun Zou
Summary: Ankylosing spondylitis (AS) is an inflammatory arthritis primarily affecting the spine, with unclear pathogenesis involving immune and skeletal system disorders. Osteoimmunology researches the complex interactions between bone and immune systems in AS, highlighting the significance of interactions between bone cells and immune cells in the pathogenesis of AS.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biology
Maria-Bernadette Madel, Julia Halper, Lidia Ibanez, Lozano Claire, Matthieu Rouleau, Antoine Boutin, Adrien Mahler, Rodolphe Pontier-Bres, Thomas Ciucci, Majlinda Topi, Christophe Hue, Jerome Amiaud, Salvador Iborra, David Sancho, Dominique Heymann, Henri-Jean Garchon, Dorota Czerucka, Florence Apparailly, Isabelle Duroux-Richard, Abdelilah Wakkach, Claudine Blin-Wakkach
Summary: This study explores the specific traits of inflammatory and steady-state osteoclasts using transcriptomic profiling, differentiation assays, and in vivo analysis in mice. The authors identify and validate pattern-recognition receptors (PRR) Tlr2, Dectin-1, and Mincle as major regulators of inflammatory osteoclasts. They demonstrate that the administration of the yeast probiotic Saccharomyces boulardii CNCM I-745 (Sb) reduces bone loss in ovariectomized mice by regulating the inflammatory environment and inhibiting inflammatory osteoclastogenesis. The study also shows that Sb derivatives and agonists of Tlr2, Dectin-1, and Mincle specifically inhibit the differentiation of inflammatory osteoclasts in vitro. These findings have important implications for the development of therapeutic strategies for inflammatory bone loss.
Article
Immunology
Hailin Huang, Fangze Guo, Xuyang Deng, Mingzhe Yan, Danyang Wang, Zhanyi Sun, Changqing Yuan, Qihui Zhou
Summary: Fucoidan has immunomodulatory effects on macrophages, neutrophils, and natural killer cells. It also promotes T cell proliferation and affects osteogenesis. This research provides new insights into the interplay between fucoidan, T cells, and osteoblasts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Fangze Guo, Changqing Yuan, Hailin Huang, Xuyang Deng, Zirui Bian, Danyang Wang, Keke Dou, Li Mei, Qihui Zhou
Summary: In this study, the effects of nano-hydroxyapatite (nHA) on T cells and its regulatory interplay on osteogenic differentiation were investigated. It was found that increasing nHA concentration promoted T cell proliferation and reduced the proportion of apoptotic T cells. Furthermore, CD4(+) T cells were more affected by nHA compared to CD8(+) T cells, and the supernatant of T cells co-cultured with nHA significantly inhibited osteogenic differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Immunology
Ya-nan Wang, Shiyue Liu, Tingting Jia, Yao Feng, Wenjing Zhang, Xin Xu, Dongjiao Zhang
Summary: Osteoimmunology highlights the complex interplay between bone and immune cells, with TCPTP playing a crucial role in regulating immune responses and bone metabolism. TCPTP negatively regulates macrophage activation and inflammatory factors secretion to inhibit bone resorption, while also modulating T lymphocytes and B lymphocytes to maintain bone homeostasis. This review provides valuable insights into the potential therapeutic targeting of TCPTP for inflammatory bone loss.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Changjun Chen, Xin Zhao, Yue Luo, Bohua Li, Qianhao Li, Chengcheng Zhao, Yan Huang, Pengde Kang
Summary: The imbalance of T-cell subsets may be involved in the pathophysiological process of ONFH, and diminished CD4(+)/FoxP3(+) T regulatory cells may be associated with increased RANKL(+) T cells in the bone marrow of the femoral head in GC-ONFH, which may facilitate bone resorption and collapse of the femoral head.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Betsabel Chicana, Nastaran Abbasizadeh, Christian Burns, Hanna Taglinao, Joel A. Spencer, Jennifer O. Manilay
Summary: This study investigates the mechanisms of B cell defects in bone marrow caused by the loss of von-Hippel Lindau protein (VHL). The result shows that there is an increase in the frequency and number of B cell progenitors in VhlcKO bone marrow, while Fransctions B-F are decreased. VhlcKO B cells exhibit increased apoptosis and quiescence. Reciprocal BM chimeras confirm that the B cell defects in VhlcKO are derived from extrinsic sources.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Hongtao Liu, Chongxian Pan, Wenru Song, Delong Liu, Zihai Li, Lei Zheng
Summary: Cell therapy has advanced rapidly in recent years, with applications expanding beyond hematologic malignancies to solid tumors, targeting personalized tumor-specific neoantigens and enhancing T cell trafficking. Despite challenges, the maturation of technologies in T cell engineering is expected to lead a revolution in cancer immunotherapy in the near future.
BIOMARKER RESEARCH
(2021)
Review
Cell Biology
Verena Fischer, Melanie Haffner-Luntzer
Summary: Postmenopausal osteoporosis is a systemic disease caused by the loss of bone mass and increased fracture risk, resulting from reduced estrogen levels after menopause. The alterations of immune cells contribute to the development of bone destruction in addition to the direct negative effects of estrogen-deficiency on bone.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Xiaowen Zhang, Kwong-Wai Man, Gloria Hoi-Yee Li, Kathryn C. B. Tan, Annie Wai-Chee Kung, Ching-Lung Cheung
Summary: Bone mineral density (BMD) is associated with the risk of common infections and sepsis. Higher BMD at the femoral neck and total hip is associated with a decreased risk of pneumonia, urinary tract infection, skin infection, and sepsis. BMD at the lumbar spine is only associated with the risk of skin infection. Participants with osteoporosis have a significantly higher risk of infections and sepsis compared to those with normal BMD.
Article
Biochemistry & Molecular Biology
Verena Fischer, Jasmin Maria Buelow, Benjamin Thilo Krueger, Deniz Ragipoglu, Anna Vikman, Melanie Haffner-Luntzer, Konstantinos Katsoulis-Dimitriou, Anne Dudeck, Anita Ignatius
Summary: Previous studies have shown that an increase in mast cells in the bone marrow is associated with age-related and post-menopausal osteoporosis. However, this study found that mast cell-derived RANKL does not contribute to the development of post-menopausal osteoporosis, suggesting that other factors may be responsible for this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Milan Kumar Sharma, Prafulla Regmi, Todd Applegate, Lilong Chai, Woo Kyun Kim
Summary: Bone serves multiple functions in avian species, including providing structural integrity, aiding locomotion and flight, and regulating mineral homeostasis. Gastrointestinal diseases in poultry can negatively impact bone quality, but the mechanisms linking the two are not fully understood. Immune-mediated osteoclastogenesis and cytokine-mediated pathways may play a role in accelerated bone loss after gastrointestinal illnesses like coccidiosis and necrotic enteritis.
Article
Immunology
Jitender Singh, Deepti Malik, Ashvinder Raina
Summary: COVID-19 has caused massive destruction worldwide and the prospect of repeated lockdowns is concerning. This study identified potential B-cell and T-cell epitopes using computational methods, providing new pathways for vaccine development against COVID-19.
Review
Engineering, Biomedical
Gemma Mestres, Sarah-Sophia D. Carter, Nils P. Hailer, Anna Diez-Escudero
Summary: Biomaterials offer a promising approach to repair bone defects, with a focus on osteoimmunology to modulate the immune response and to support bone regeneration. Various in vitro assays are used to evaluate the OIM properties of biomaterials, but selecting the right methods can be challenging. This review aims to provide a comprehensive guide for researchers interested in studying the OIM properties of biomaterials in vitro.
ACTA BIOMATERIALIA
(2021)