期刊
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
卷 20, 期 3, 页码 234-239出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MED.0b013e32835f3d4b
关键词
chemicals; endocrine disruption; epidemiology; exposure; semen quality
资金
- Danish Medical Research Council
- EU Interreg IV
- European 7th Framework Program
- Danish Work Environment Research Foundation
Purpose of review To highlight and discuss the new evidence on occupational and environmental risk to male reproductive function. Recent findings Semen quality following occupational exposure to boron (an acknowledged experimental reproductive toxicant) and benzene, and new evidence on low-level environmental exposure to widespread xenobiotics with endocrine actions. Summary The naturally occurring semimetal boron is an experimental reproductive toxicant, but now a Turkish semen study corroborates earlier evidence that high-level occupational exposure is not toxic to human spermatogenesis. It seems that human exposure levels are below the levels that cause reproductive toxicity in rodents. On the contrary, there is now ample evidence that the carcinogenic substance benzene may cause chromosomal aberrations in sperm at very low exposure levels. This includes chromosomal deletions that are known to cause infertility, mental retardation and congenital malformations. This research highlights the need to scrutinize the chemicals for possible male-mediated developmental toxicity. Several occupational studies are addressing adult testicular function in men exposed to chemicals that may interfere with endocrine signalling such as bisphenol A and phthalates, but findings are rather inconsistent and it remains to be established whether these widespread chemicals have any impact on male fertility.
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