Article
Agriculture, Dairy & Animal Science
Claudio A. Alvarez, Paula A. Santana, Claudia B. Carcamo, Constanza Cardenas, Byron Morales-Lange, Felipe Ramirez, Cristian Valenzuela, Sebastian Boltana, Javier Alcaino, Fanny Guzman, Luis Mercado
Summary: This study evaluated the effect of different stock densities on the gene expression of brain and gastrointestinal hormone signalers in Salmo salar post-smolt. High stock densities were found to promote the levels of molecules associated with feed inhibition, which could be used as biological markers to improve production practices in fish aquaculture.
Article
Immunology
Tian Jiang, Wenwei Lu, Zhifeng Fang, Hongchao Wang, Jinlin Zhu, Hao Zhang, Jianxin Zhao
Summary: This study compared three different microencapsulation methods and found that Bifidobacteria treated by electrostatic spray drying had the best ability to alleviate constipation by changing the composition of intestinal microbiota and increasing the level of intestinal AQP3.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Matti L. Gild, Mark Stuart, Roderick J. Clifton-Bligh, Audrey Kinahan, David J. Handelsman
Summary: Abuse of hormones is common in elite sports, with androgens and erythropoietin being the most prohibited substances. The prohibition of thyroid hormone (TH) use remains controversial, but based on present data, it is neither justified nor feasible to prohibit TH in elite sports.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Medicinal
Ragnhild G. Ohm, Mukandila Mulumba, Ramesh M. Chingle, Ahsanullah, Jinqiang Zhang, Sylvain Chemtob, Huy Ong, William D. Lubell
Summary: Expanding cyclic peptide diversity through A(3)-macrocyclization and introducing new components has shown the importance of triple bonds and residues like N-epsilon-allyl lysine in high CD36 binding affinity, aiding in the development of ideal CD36 modulators to curb macrophage-driven inflammation.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Fengyuan Xu, Ialu Shi, Xueyun Qin, Zimeng Zheng, Min Chen, Zhi Lin, Jiangfeng Ye, Mingqing Li
Summary: Endocrine-related cancers and hormones are closely linked, with hormones playing a crucial role in tumor induction and progression. The role of glutamine metabolism in mediating tumorigenesis and development, as well as the regulation of glutamine metabolism by hormones such as estrogen, progesterone, androgen, prostaglandin, thyroid hormone, and insulin, have been extensively studied. However, the relationship between these three factors still needs to be further elucidated. This review provides an updated overview of glutamine metabolism traits and its influence on endocrine oncology, as well as its upstream hormonal regulation. The hormone/glutamine metabolism axis may serve as a potential target for novel therapeutic strategies in endocrine-related cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Zhongxia Wu, Libin Yang, Qiongjie He, Shutang Zhou
Summary: Insect vitellogenesis is regulated by a combination of hormones, miRNA, and nutritional signaling pathways, showing the importance of the coordination of these mechanisms in controlling insect reproduction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Akimasa Adachi, Tetsuya Honda
Summary: Psoriasis is a chronic inflammatory skin disease associated with the interleukin-23/interleukin-17 axis, and female sex hormones, specifically estrogens, play a significant role in its development by suppressing the production of psoriasis-related cytokines.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Daisuke Saito, Yuko Nakagawa, Takashi Sato, Ayako Fukunaka, Ofejiro Blessing Pereye, Nobuhiro Maruyama, Hirotaka Watada, Yoshio Fujitani
Summary: In this study, we developed a method to specifically detect and measure the secretion of pancreatic polypeptide (PP), and investigated the molecular mechanisms that regulate PP secretion. We found that the secretion of PP is triggered by an increase in intracellular calcium concentrations via voltage-dependent calcium channels, unlike the mechanism of insulin secretion.
Article
Food Science & Technology
Weijia Li, Haoming Li, Jia Li, Jia Xu, Li Fang, Chunlei Liu, Dan Wu, Weihong Min
Summary: This study explored the relationship between the digestion of walnut peptide (<3 kDa) and its antioxidant activity, focusing on the inhibitory effect of DPP-IV on the antioxidant peptide KGHLFPN. The results showed that after simulated gastrointestinal digestion, the antioxidant capacity of the peptides was enhanced, while their tertiary structures became weaker and secondary structures became random coiled. The study also found that the antioxidant walnut peptide KGHLFPN exhibited good DPP-IV inhibitory activity, and the optimal time for oral absorption of KGHLFPN in vivo was found to be 4-8 hours. Therefore, walnut protein hydrolysate (<3 kDa) can be used as an antioxidant precursor, and walnut peptides have the potential to serve as food-derived antioxidants.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Brian Finan, Sebastian D. Parlee, Bin Yang
Summary: NASH is a spectrum of liver pathologies triggered by factors like fat accumulation, insulin resistance, and dyslipidemia. Emerging combinatorial therapeutic approaches may help overcome challenges faced by NASH drug candidates in early clinical trials.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Elin Manell, Emmi Puuvuori, Anna Svensson, Irina Velikyan, Gry Hulsart-Billstrom, Patricia Hedenqvist, Jens Juul Holst, Marianne Jensen Waern, Olof Eriksson
Summary: The study examined GLP-1 receptor distribution and occupancy in pigs, finding high uptake of Lu-177-exendin-4 in the pancreas and duodenum, with lower uptake in other gastrointestinal areas. During OGTT, there was no increase in plasma GLP-1 concentrations and low GLP-1R occupancy. The findings suggest differences in GLP-1R distribution and response to OGTT in pigs compared to humans, providing new insights for porcine diabetes models.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Multidisciplinary Sciences
Frederique Ruf-Zamojski, Zidong Zhang, Michel Zamojski, Gregory R. Smith, Natalia Mendelev, Hanqing Liu, German Nudelman, Mika Moriwaki, Hanna Pincas, Rosa Gomez Castanon, Venugopalan D. Nair, Nitish Seenarine, Mary Anne S. Amper, Xiang Zhou, Luisina Ongaro, Chirine Toufaily, Gauthier Schang, Joseph R. Nery, Anna Bartlett, Andrew Aldridge, Nimisha Jain, Gwen Childs, Olga G. Troyanskaya, Joseph R. Ecker, Judith L. Turgeon, Corrine K. Welt, Daniel J. Bernard, Stuart C. Sealfon
Summary: In order to investigate transcriptional regulatory mechanisms, a team profiled the transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei from adult mouse pituitaries. They identified transcriptional and chromatin accessibility programs distinguishing each major cell type, as well as co-regulated gene sets that recapitulate cell type clustering. The study highlights the centrality of chromatin accessibility in shaping cell-defining transcriptional programs.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jenny J. Seo, Soo-Jin Jung, Jihye Yang, Da-Eun Choi, V. Narry Kim
Summary: Recent advancements in the sequencing of viral genomes have allowed for a better understanding of viral diversity and unknown regulatory mechanisms. In this study, researchers screened 30,367 viral segments from 143 species and identified hundreds of elements impacting RNA abundance, translation, and distribution. By investigating a conserved element called K5, they discovered its ability to enhance mRNA stability and translation. Additionally, they identified a previously unknown protein, ZCCHC2, as a critical host factor for K5. This study provides valuable information for virus and RNA research and highlights the potential of the virosphere for biological discoveries.
Review
Biochemistry & Molecular Biology
Pulak R. Manna, Ahsen U. Ahmed, Deborah Molehin, Madhusudhanan Narasimhan, Kevin Pruitt, P. Hemachandra Reddy
Summary: This article investigates the molecular pathogenesis and therapeutic strategies for hormone receptor positive breast cancer, with a focus on the role of steroidogenic acute regulatory (StAR) protein, suggesting that StAR could serve as both a prognostic marker and a therapeutic candidate in the prevention and treatment of this life-threatening disease.
Review
Cell Biology
Ping Lyu, Bo Li, Peiran Li, Ruiye Bi, Chen Cui, Zhihe Zhao, Xuedong Zhou, Yi Fan
Summary: This article reviews the effects of PTH, PTHrP, and PTH1R signaling on MSCs in the orofacial region, as well as the potential therapeutic applications for dental and bone regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
