Review
Medicine, General & Internal
Anna Pliszka, Sebastian Rajda, Agata Wawrzyniak, Jerzy Walocha, Michal Polguj, Grzegorz Wysiadecki, Edward Clarke, Michal Golberg, Michal Zarzecki, Krzysztof Balawender
Summary: This systematic review aimed to summarize current knowledge on testicular metastasis of renal cell carcinoma (RCC). It was found that approximately one-third of RCC cases are recognized in its metastatic stage. Testicular metastasis suggests advanced disease stage, with swelling and enlargement of the affected testis as the main symptoms. Understanding the possibility of such RCC metastases is crucial for making an appropriate diagnosis and implementing timely treatment in the management of neoplastic disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Margaret F. Meagher, Maria C. Mir, Andrea Minervini, Maximilian Kriegmair, Matthias Heck, Francesco Porpiglia, Siska Van Bruwaene, Estefania Linares, Vital Hevia, Maurizio D'Anna, Alessandro Veccia, Eduard Roussel, Francesco Claps, Carlotta Palumbo, Michele Marchioni, Jonathan Afari, Cesare Saitta, Franklin Liu, Jose Rubio, Riccardo Campi, Andrea Mari, Thomas Amiel, Enrico Checcucci, Mireia Musquera, Georgi Guruli, Nicola Pavan, Maarten Albersen, Alessandro Antonelli, Tobias Klatte, Riccardo Autorino, Rana R. McKay, Ithaar H. Derweesh
Summary: The study aimed to determine the accuracy of a proposed two-tier re-classification of the M domain in the TNM staging of RCC. The analysis of patients from the REMARCC database showed that the M2 classification was an independent risk factor for worsened mortality. Comparisons between M1 and M2 groups demonstrated significant differences in overall survival and cancer-specific survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Kazuyuki Numakura, Yuya Sekine, Shingo Hatakeyama, Yumina Muto, Ryuta Sobu, Mizuki Kobayashi, Hajime Sasagawa, Soki Kashima, Ryohei Yamamto, Taketoshi Nara, Hideo Akashi, Ryuji Tabata, Satoshi Sato, Mitsuru Saito, Shintaro Narita, Chikara Ohyama, Tomonori Habuchi
Summary: This study investigated primary resistance to NIVO+IPI as a first-line treatment in patients with metastatic renal cell carcinoma (mRCC). It found that approximately 20% of patients developed primary resistant disease (PRD) with worse survival rates. Lymph node metastasis (LNM) was identified as an independent risk factor for PRD.
Article
Pathology
Julien Dagher, Angelique Brunot, Bertrand Evrard, Solene-Florence Kammerer-Jacquet, Marion Beaumont, Laurence Cornevin, Fanny Derquin, Gregory Verhoest, Karim Bensalah, Alexandra Lespagnol, Frederic Dugay, Marc-Antoine Belaud-Rotureau, Frederic Chalmel, Nathalie Rioux-Leclercq
Summary: Metastatic evolution in clear cell renal cell carcinoma is complex, with tumor heterogeneity resulting from clonal evolution playing a role in metastatic dissemination. Using an integrative multiomics strategy, it was found that all sites were heterogeneous and polyclonal, with each tumor site containing two aggressive subclonal populations.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Urology & Nephrology
Rodrigo Rodrigues Pessoa, Reza Nabavizadeh, Fernando Quevedo, Daniel D. Joyce, Christine M. Lohse, Vidit Sharma, Brian A. Costello, Stephen A. Boorjian, R. Houston Thompson, Bradley C. Leibovich, John C. Cheville
Summary: This study compared different models using clinical, primary tumor, and metastatic features to predict cancer-specific survival for patients with surgically resected metastatic clear cell renal cell carcinoma. The findings showed that scoring algorithms calculated using histopathological features of the metastasis can be used to predict cancer-specific survival, which is particularly important when primary tumor histopathology is not readily available.
JOURNAL OF UROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Natalie L. Demirjian, Bino A. Varghese, Steven Y. Cen, Darryl H. Hwang, Manju Aron, Imran Siddiqui, Brandon K. K. Fields, Xiaomeng Lei, Felix Y. Yap, Marielena Rivas, Sharath S. Reddy, Haris Zahoor, Derek H. Liu, Mihir Desai, Suhn K. Rhie, Inderbir S. Gill, Vinay Duddalwar
Summary: This study evaluated the utility of CT-based radiomics signatures in discriminating low-grade and high-grade, as well as low-stage and high-stage clear cell renal cell carcinomas (ccRCC). The results suggest that CT-based radiomics signatures have the potential to be valuable in distinguishing between different grades and stages of ccRCC.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Giacomo Maria Pini, Roberta Luciano, Maurizio Colecchia
Summary: Renal cancer is a common malignant neoplasm, with clear cell renal cell carcinoma (CCRCC) being the most frequent type. Cystic forms of renal cancer can be challenging to differentiate from other subtypes. The presence of cystic areas in renal tumors can be due to various factors, such as intrinsic cystic architecture, pseudocystic degeneration, or cystically dilated renal tubules. Differential diagnosis of cystic renal neoplasms requires specific criteria and analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zaosong Zheng, Zhiliang Chen, Yingwei Xie, Qiyu Zhong, Wenlian Xie
Summary: Radiomics analysis was used to develop a CT-based nomogram for preoperative prediction of nuclear grades in ccRCC, showing good accuracy in discriminating nuclear grades and providing individualized treatment for patients.
EUROPEAN RADIOLOGY
(2021)
Article
Cell Biology
Guodong Fang, Xudan Wang
Summary: This study identified nine genes associated with clinical traits and prognosis in clear cell renal cell carcinoma (ccRCC). A risk signature constructed by these genes could predict patient survival probabilities. Patients in the high-risk group showed a higher response rate to immunotherapy and this may be related to dendritic cell-mediated immunosuppression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Chirag Krishna, Renzo G. DiNatale, Fengshen Kuo, Raghvendra M. Srivastava, Lynda Vuong, Diego Chowell, Sounak Gupta, Chad Vanderbilt, Tanaya A. Purohit, Ming Liu, Emily Kansler, Briana G. Nixon, Ying-Bei Chen, Vladimir Makarov, Kyle A. Blum, Kyrollis Attalla, Stanley Weng, Michael L. Salmans, Mahdi Golkaram, Li Liu, Shile Zhang, Raakhee Vijayaraghavan, Traci Pawlowski, Victor Reuter, Maria Carlo, Martin H. Voss, Jonathan Coleman, Paul Russo, Robert J. Motzer, Ming O. Li, Christina S. Leslie, Timothy A. Chan, A. Ari Hakimi
Summary: Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, and this study investigates the immune landscape of ccRCC using paired single-cell RNA (scRNA) and T cell receptor (TCR) sequencing, revealing extensive heterogeneity within and between patients. The study shows that tissue-resident T cells and tumor-associated macrophages (TAMs) are associated with responses to immune checkpoint blockade (ICB) and targeted therapies, highlighting the importance of cellular programs in therapeutic efficacy for ccRCC.
Article
Biology
Maeva Dufies, Annelies Verbiest, Lindsay S. Cooley, Papa Diogop Ndiaye, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andreas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie M. Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti, Gilles Pages
Summary: Dufies et al. found high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discovered that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also found that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor against VEGF receptor, suggesting a critical role for hypoxia/HIF-2-induced Plk1 in disease progression.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, General & Internal
Gaetano Aurilio, Giovanni Mauri, Duccio Rossi, Paolo Della Vigna, Guido Bonomo, Gianluca Maria Varano, Daniele Maiettini, Maria Cossu Rocca, Elena Verri, Daniela Cullura, Franco Nole, Franco Orsi
Summary: Renal cell carcinoma is a common tumor with high recurrence and metastasis rates. Image-guided ablation techniques, such as microwave, radiofrequency, cryo, and laser, can effectively control tumor progression. Systemic treatment can be initiated at a certain time after the ablation. The primary success and efficacy rates were high, and no significant complications occurred.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Arun R. Menon, Ahmed A. Hussein, Kristopher M. Attwood, Tashionna White, Gaybrielle James, Bo Xu, Michael Petroziello, Charles L. Roche, Eric C. Kauffman
Summary: This study introduced a novel approach of active surveillance for patients with small renal masses who did not meet predefined progression criteria for intervention. The majority of patients with small renal masses did not require immediate intervention, and delayed intervention focused on those with malignant pathology at risk. Further research is needed to study the long-term outcomes of delayed intervention and oncologic safety.
JOURNAL OF UROLOGY
(2021)
Article
Pathology
Regina Kwon, Pedram Argani, Jonathan Epstein, Kara A. Lombardo, Xiaoming Wang, Phillip M. Pierorazio, Rohit Mehra, Andres Matoso
Summary: Our study focused on reclassifying adult unclassified RCC, identifying 79 cases and successfully reclassifying 10 cases based on morphological features and ancillary studies. The most frequently reclassified entity was eosinophilic solid and cystic RCC.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Medicine, General & Internal
Tae-Soo Choi, Dong-Gi Lee, Kyu-Yeoun Won, Gyeong-Eun Min
Summary: Tubulocystic renal cell carcinoma is a rare subtype of kidney cancer with mostly indolent behavior, but some cases can exhibit aggressive features. Treatment may involve a combination of targeted therapy and radiofrequency ablation for recurrent tumors.
MEDICINA-LITHUANIA
(2021)
Article
Urology & Nephrology
P. Romao, I. de Campos Souza, I Silva, V. Ribeiro Guimaraes, J. Alves de Camargo, G. A. dos Santos, N. Izabel Viana, M. Srougi, K. R. Moreira Leite, S. T. Reis, R. Pimenta
Summary: The study found that the AR gene was downregulated in the PC3 cell line, and X chromosome polysomy was present in both PC3 and LNCaP cell lines. HUMARA-Q assay revealed that both X chromosomes in PC3 cells exhibited AR activity, while only one AR gene was methylated in LNCaP cells.
ACTAS UROLOGICAS ESPANOLAS
(2022)
Article
Surgery
Eduardo A. Fonseca, Flavia Feier, Rodrigo Vincenzi, Helry L. L. Candido, Rodrigo L. Azambuja, Fabio Payao, Marcel R. Benavides, Karina M. O. Roda, Katia M. R. Leite, Cristiane M. F. Ribeiro, Maria D. Begnami, Charles E. Zurstrassen, Francisco C. Carnevale, Paulo Chapchap, Joao Seda-Neto
Summary: This study presents three cases of large hepatocellular adenomas with central location that utilized living donor liver transplantation as a backup procedure. All patients were diagnosed with hepatocellular adenomas before surgery, and the decision for surgical resection was based on symptoms, lesion size, and growth, with the final decision made intraoperatively.
CASE REPORTS IN SURGERY
(2022)
Correction
Oncology
Katia R. M. Leite, Alberto Tomiyama, Sabrina T. Reis, Juliana M. Sousa-Canavez, Adriana Sanudo, Luiz H. Camara-Lopes, Miguel Srougi
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Oncology
Gabriel Arantes dos Santos, Nayara I. Viana, Ruan Pimenta, Juliana Alves de Camargo, Vanessa R. Guimaraes, Poliana Romao, Patricia Candido, Vitoria Ghazarian, Sabrina T. Reis, Katia Ramos Moreira Leite, Miguel Srougi
Summary: This study investigates the role of the CST complex in various types of cancer and reveals its importance in genetic stability, nucleic acid metabolism, and immune regulation. The study identifies potential interactors, transcription factors, and microRNAs associated with CST, as well as drugs that may disrupt CST pathways.
Article
Medicine, General & Internal
Gustavo N. C. Inoue, Ruan Pimenta, Juliana A. Camargo, Nayara Viana, Vanessa R. Guimaraes, Miguel Srougi, William C. Nahas, Katia R. M. Leite, Sabrina T. Reis
Summary: The combination of spinal and general anesthesia may attenuate the suppression of innate tumor immunity and it may be related to a reduction in the neuroendocrine response to surgery.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Claudio B. Murta, Tatiane K. Furuya, Alexis G. M. Carrasco, Miyuki Uno, Laura Sichero, Luisa L. Villa, Sheila F. Faraj, Rafael F. Coelho, Giuliano B. Guglielmetti, Mauricio D. Cordeiro, Katia R. M. Leite, William C. Nahas, Roger Chammas, Jose Pontes
Summary: This study aimed to identify potential biomarkers for lymph node metastasis and prognosis in penile cancer (PeC). The study found miRNA and gene expression profiles associated with metastasis and prognosis, as well as revealed the disruption of mRNA-miRNA regulation during disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Victor Srougi, Rodolfo Anisio Santana de Torres Bandeira, Sabrina Thalita Reis, Gabriel Arantes dos Santos, Hiury da Silva Andrade, Katia Ramos Moreira Leite, David Hamilton-Cho, Anuar Ibrahim Mitre, Marco Antonio Arap, Miguel Srougi, Ricardo Jordao Duarte
Summary: Patients with high ICC density experience significant improvement in hydronephrosis following pyeloplasty, but ICC density is not associated with functional outcomes.
Editorial Material
Urology & Nephrology
Kenneth A. Iczkowski, Mariel Molina, Lars Egevad, David G. Bostwick, Geert J. L. H. van Leenders, Francisco G. La Rosa, Theodorus van der Kwast, Daniel M. Berney, Andrew J. Evans, Thomas M. Wheeler, Katia R. M. Leite, Hemamali Samaratunga, John Srigley, Murali Varma, Toyonori Tsuzuki, Marshall Scott Lucia, Elward David Crawford, Richard G. Harris, Philip Stricker, Nathan Lawrentschuk, Henry H. Woo, Neil E. Fleshner, Neal D. Shore, John Yaxley, Ola Bratt, Peter Wiklund, Matthew Roberts, Liang Cheng, Brett Delahunt
Article
Pathology
Hemamali Samaratunga, Lars Egevad, Michelle Thunders, Kenneth A. Iczskowski, Theodorus van der Kwast, Glen Kristiansen, Chin-Chen Pan, Katia R. M. Leite, Andrew Evans, David Clouston, Diane N. Kenwright, Peter B. Bethwaite, Greg Malone, Simon Wood, John W. Yaxley, Brett Delahunt
Summary: The classification of malignant tumors is influenced by immunohistochemical and molecular genetic findings. Renal oncocytoma, a benign tumor, can occasionally exhibit malignant behavior as a variant called hybrid oncocytic chromophobe tumor. Two new entities, low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) with varying nuclear pleomorphism, have been proposed. The diagnosis of these apparently benign tumors is based on morphological, immunohistochemical features, and mutations in the mTOR pathway. However, the importance and specificity of these tumors are still debatable.
Article
Cell Biology
Lars Egevad, Brett Delahunt, Kenneth A. Iczkowski, Theo van der Kwast, Geert J. L. H. van Leenders, Katia R. M. Leite, Chin-Chen Pan, Hemamali Samaratunga, Toyonori Tsuzuki, Nita Mulliqi, Xiaoyi Ji, Henrik Olsson, Masi Valkonen, Pekka Ruusuvuori, Martin Eklund, Kimmo Kartasalo
Summary: There is evidence that cribriform morphology is associated with a worse prognosis for prostatic adenocarcinoma. This study aimed to investigate the reproducibility of cribriform cancer diagnosis in prostate needle biopsies. A panel of nine prostate pathology experts independently reviewed 304 digitised biopsies and achieved a 2/3 consensus diagnosis of cribriform and noncribriform cancer in 90% of the cases. Strict diagnostic criteria were used to identify cribriform patterns and generate a set of consensus cases for standardization.
Article
Surgery
Maira Suzuka Kudo, Vinicius Meneguette Gomes de Souza, Carmen Liane Neubarth Estivallet, Henrique Alves de Amorim, Fernando J. Kim, Katia Ramos Moreira Leite, Matheus Cardoso Moraes
Summary: The study utilized artificial intelligence methods to construct a CNN for classifying Gleason patterns with high accuracy. In the test phase, the true positive ratio between pathologist and computer method reached 85% to 96%. Precision, sensitivity, and specificity all reached up to 97%.
PATIENT SAFETY IN SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Ruan Pimenta, Carolina Mie Mioshi, Guilherme L. Goncalves, Patricia Candido, Juliana A. Camargo, Vanessa R. Guimaraes, Caroline Chiovatto, Vitoria Ghazarian, Poliana Romao, Karina Serafim da Silva, Gabriel A. dos Santos, Iran A. Silva, Miguel Srougi, William C. Nahas, Katia R. Leite, Nayara I. Viana, Sabrina T. Reis
Summary: This study aimed to evaluate the suppressive effect of miR-137 in prostate cancer, regardless of diet-induced hypercholesterolemia. The results showed that miR-137 could inhibit the transcription and translation of the p160 family, SRC-1, SRC-2, and SRC-3, and indirectly reduce the expression of AR. It also inhibited cell migration and invasion, reduced proliferation, and increased apoptosis rates. In vivo experiments demonstrated that tumor growth was arrested after intratumoral restoration of miR-137, with a more significant response in the hypercholesterolemic group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Isadora Oliveira Ansaloni Pereira, Glenda Nicioli da Silva, Tamires Cunha Almeida, Ana Paula Braga Lima, Andre Luiz Ventura Savio, Katia Ramos Moreira Leite, Daisy Maria Favero Salvadori
Summary: Long non-coding RNAs are frequently dysregulated and have been associated with carcinogenesis, aggressiveness, and chemoresistance in tumors. In this study, we investigated the combined expression of JHDM1D and JHDM1D-AS1 in bladder tumors, and found that it can distinguish between low-grade and high-grade tumors. We also discovered that silencing JHDM1D-AS1 can reduce the growth and proliferation of high-grade bladder tumor cells and increase their sensitivity to gemcitabine treatment.
Meeting Abstract
Oncology
Diogo Assed Bastos, Rafael Coelho, Leonardo Cardili, Felipe Galiza, Eder Nisi Ilario, Ublio Viana, Claudio Bovolenta Murta, Giuliano Guglielmetti, Mauricio Cordeiro, Jose Pontes, David Queiroz Borges Muniz, Jamile Almeida Silva, Jose Mauricio Mota, Guilherme Fialho De Freitas, Katia Ramos Moreira Leite, Carlos Alberto Buchpiguel, William Carlos Nahas
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Urology & Nephrology
C. B. Murta, T. K. Furuya, M. Uno, A. G. M. Carrasco, L. Sichero, L. L. Villa, S. F. Faraj, R. F. Coelho, G. B. Guglielmetti, M. D. Cordeiro, K. R. M. Leite, W. C. Nahas, R. Chammas, Jr J. Pontes