Article
Neurosciences
Aurelie Edwards, Kimberly R. Long, Catherine J. Baty, Katherine E. Shipman, Ora A. Weisz
Summary: Recent research shows that filtered albumin is mainly retrieved in proximal tubule through receptor-mediated endocytosis. A mathematical model is developed to predict the rates of albumin uptake and suggests that megalin-mediated uptake predominates under nephrotic conditions. The majority of albumin is reabsorbed in the S1 sub-segment.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Pharmacology & Pharmacy
Mark A. Bryniarski, Bei Zhao, Lee D. Chaves, Jakob Hauge Mikkelsen, Benjamin M. Yee, Rabi Yacoub, Shichen Shen, Mette Madsen, Marilyn E. Morris
Summary: Therapeutic immunoglobulin G (IgG) antibodies are important protein therapeutics, and research has indicated that megalin and cubilin may serve as receptors for the entry of IgG into various tissues or cells. Experimental findings suggest that megalin has a high affinity for binding and internalizing IgG.
Review
Physiology
Bruce A. Molitoris, Ruben M. Sandoval, Shiv Pratap S. Yadav, Mark C. Wagner
Summary: The proximal tubule plays a crucial role in the reabsorption, processing, and transcytosis of albumin, which can prevent its loss in urine and prolong its serum half-life. Understanding the mechanisms involved in albumin metabolism by proximal tubule cells is important not only for physiological functions but also for therapeutic applications.
PHYSIOLOGICAL REVIEWS
(2022)
Review
Medicine, Research & Experimental
Elsayed G. E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Ahmed Ismail, Ahmed S. Doghish
Summary: The endocytosis mechanism is a complex system essential for cell signaling and survival. Megalin and its related proteins play important roles in receptor-mediated endocytosis and have significant implications for kidney function and injury.
Review
Neurosciences
Ora A. Weisz
Summary: The article describes the mechanism of protein recycling in the renal tubules and its behavior in different states, proposing an integrated new working model that explains the role of fluid phase uptake in recovering high concentrations of protein in conditions of impaired filtration barrier. This model considers the independent pathways of fluid phase and receptor-mediated uptake, as well as the impact of protein load on physiological and pathological states.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Pharmacology & Pharmacy
Bei Zhao, Chengjian Tu, Shichen Shen, Jun Qu, Marilyn E. Morris
Summary: Megalin and cubilin, endocytic proteins in the kidney, are responsible for reabsorbing filtered proteins from urine. By comparing urinary protein differences between kidney-specific megalin knockdown (KD) mice and control (WT) mice, potential megalin/cubilin substrates were identified. The study discovered 877 potential substrates, including 23 known substrates, and found significant differences in the levels of certain proteins between KD and WT mice.
Article
Medicine, General & Internal
Michael A. Puskarich, Nathan W. Cummins, Nicholas E. Ingraham, David A. Wacker, Ronald A. Reilkoff, Brian E. Driver, Michelle H. Biros, Fernanda Bellolio, Jeffrey G. Chipman, Andrew C. Nelson, Kenneth Beckman, Ryan Langlois, Tyler Bold, Matthew T. Aliota, Timothy W. Schacker, Helen T. Voelker, Thomas A. Murray, Joseph S. Koopmeiners, Christopher J. Tignanelli
Summary: The study found that losartan did not reduce hospitalizations in low-risk outpatients with mild symptomatic COVID-19, and viral load was not affected by the treatment. This suggests that initiation of losartan treatment for this group is not supported.
Article
Oncology
Salvatore Panza, Rocco Malivindi, Amanda Caruso, Umberto Russo, Francesca Giordano, Balazs Gyorffy, Luca Gelsomino, Francesca De Amicis, Ines Barone, Francesca Luisa Conforti, Cinzia Giordano, Daniela Bonofiglio, Stefania Catalano, Sebastiano Ando
Summary: Losartan, as an adjuvant pharmacological tool, may represent a potential treatment for GBM by inhibiting local estrogen production and halting cell growth. The limited mortality benefit of current treatments underscores the importance of exploring new therapeutic avenues.
Article
Biochemistry & Molecular Biology
Diogo B. Peruchetti, Paulo F. R. Barahuna-Filho, Rodrigo P. Silva-Aguiar, Thiago P. Abreu, Christina M. Takiya, Jie Cheng, Ana Acacia S. Pinheiro, Liudmila Cebotaru, William B. Guggino, Celso Caruso-Neves
Summary: The study found that the anti-proteinuric effect of losartan may be associated with modulating albumin endocytosis in PT epithelial cells. The research demonstrates that PT megalin-mediated albumin endocytosis could be a potential target for ARB treatment in renal diseases patients. These results represent a significant advancement in understanding the role of ARBs in treating renal diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Medicine, General & Internal
Qiang Wei, Li Zhang, Mei-fan Duan, Yue-mei Wang, Nan Huang, Chun-rong Song
Summary: This case study highlights the potential fetal toxicity associated with the use of losartan in pregnant women with nephrotic syndrome. Discontinuation of losartan and replacement with nifedipine led to the normalization of amniotic fluid levels, successful delivery of a healthy infant, and overall positive outcomes. Pregnant women should be informed about the risks and carefully monitored if using ARBs, with treatment adjustments made as needed to optimize maternal and infant health.
Article
Biochemistry & Molecular Biology
Takashi Nishida, Sho Akashi, Masaharu Takigawa, Satoshi Kubota
Summary: This study revealed that angiotensin II has negative effects on chondrocyte metabolism, while AT(1)R blockade can mitigate these effects, potentially reducing chondrocyte degeneration. Additionally, ANG II regulates age-related cartilage degeneration through the ANG II-AT(1)R axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nadin Hoffmann, Joerg Peters
Summary: The (pro)renin receptor (P)RR has important roles in the kidney and brain, independently of prorenin, in activating inflammatory and fibrotic responses in renal dysfunction and being linked to hypertension in the brain. By regulating pH and function of v-ATPase, (P) RR plays crucial roles in cellular homeostasis and autophagy in kidney, brain, and heart.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Eileen Dahlke, Yaman Anan, Lea Maximiliane Klie, Ariane Elisabeth Hartkopf, Franziska Theilig
Summary: The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and plays a crucial role in the reclamation of albumin by cellular transcytosis. The interaction between megalin and FcRn in the endosomal compartment was detected, which increased when endocytosis was induced. Megalin orchestrates the endocytosis and intracellular trafficking of FcRn as an early event in transcytosis.
Article
Cardiac & Cardiovascular Systems
Nicholas D. Fried, Tamara M. Morris, Anna Whitehead, Eric Lazartigues, Xinping Yue, Jason D. Gardner
Summary: Chronic nicotine exposure induces pulmonary hypertension and right ventricular remodeling in mice, while treatment with losartan, an angiotensin II type 1 receptor antagonist, can ameliorate these effects. This provides preclinical evidence for using renin-angiotensin system-based therapies in treating pulmonary hypertension, particularly in patients with a history of tobacco-product use.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Orthopedics
K. Yamaura, A. L. Nelson, H. Nishimura, J. C. Rutledge, S. K. Ravuri, C. Bahney, M. J. Philippon, J. Huard
Summary: The objective of this study was to analyze the latest evidence on the effects of losartan or Ang II receptor antagonists on cartilage repair, with a focus on their clinical relevance. The effects of losartan or Ang II receptor antagonists on cartilage repair in in vitro and in vivo animal studies were evaluated. A total of 12 studies were included in this systematic review, and qualitative evaluation was conducted for each study due to the difficulty of meta-analysis. Both in vitro and in vivo studies provide evidence to demonstrate the beneficial effects of Ang II receptor antagonists on osteoarthritis and cartilage defect models across animal species.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biochemistry & Molecular Biology
Eduardo Molina-Jijon, Omar Emiliano Aparicio-Trejo, Rafael Rodriguez-Munoz, Juan Carlos Leon-Contreras, Maria del Carmen Cardenas-Aguayo, Omar Noel Medina-Campos, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Rogelio Hernandez-Pando, Jose L. Reyes, Laura Arreola-Mendoza, Jose Pedraza-Chaverri
Article
Toxicology
Tania Jacobo-Estrada, Mariana Cardenas-Gonzalez, Mitzi Santoyo-Sanchez, Benjamin Parada-Cruz, Esther Uria-Galicia, Laura Arreola-Mendoza, Olivier Barbier
JOURNAL OF APPLIED TOXICOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Vicente Escamilla-Rivera, Marisela Uribe-Ramirez, Sirenia Gonzalez-Pozos, Subramaniam Velumani, Laura Arreola-Mendoza, Andrea De Vizcaya-Ruiz
JOURNAL OF NANOPARTICLE RESEARCH
(2016)
Article
Medicine, Research & Experimental
Yazmin Debray-Garcia, Elsa I. Sanchez, Rafael Rodriguez-Munoz, Miguel A. Venegas, Josue Velazquez, Jose L. Reyes
Article
Oncology
Dulce Avila-Rodriguez, Carmen Solano Agama, Sirenia Gonzalez-Pozos, Juan Vicente Mendez-Mendez, Alma Ortiz Plata, Laura Arreola-Mendoza, Maria E. Mendoza-Garrido
EXPERIMENTAL CELL RESEARCH
(2017)
Article
Cell Biology
Brenda I. Luna-Antonio, Rafael Rodriguez-Munoz, Carmen Namorado-Tonix, Paula Vergara, Jose Segovia, Jose L. Reyes
HISTOCHEMISTRY AND CELL BIOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Tania Jacobo-Estrada, Mitzi Santoyo-Sanchez, Frank Thevenod, Olivier Barbier
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Multidisciplinary Sciences
Eduardo Molina-Jijon, Rafael Rodriguez-Munoz, Ricardo Gonzalez-Ramirez, Carmen Namorado-Tonix, Jose Pedraza-Chaverri, Jose L. Reyes
Article
Environmental Sciences
Harry Gutierrez-Mosquera, S. B. Sujitha, M. P. Jonathan, S. K. Sarkar, Fairy Medina-Mosquera, Helcias Ayala-Mosquera, Gladis Morales-Mira, Laura Arreola-Mendoza
JOURNAL OF ENVIRONMENTAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Edith Sierra-Mondragon, Eduardo Molina-Jijon, Carmen Namorado-Tonix, Rafael Rodriguez-Munoz, Jose Pedraza-Chaverri, Jose L. Reyes
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Deyanira Guadalupe Acuna-Hernandez, Laura Arreola-Mendoza, Ramses Santacruz-Marquez, Sihomara Patricia Garcia-Zepeda, Lyda Yuliana Parra-Forero, Jesus Alberto Olivares-Reyes, Isabel Hernandez-Ochoa
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Edith Sierra-Mondragon, Rafael Rodriguez-Munoz, Carmen Namorado-Tonix, Eduardo Molina-Jijon, Daniel Romero-Trejo, Jose Pedraza-Chaverri, Jose L. Reyes
Article
Medicine, Research & Experimental
Lorena Rosas-Martinez, Rafael Rodriguez-Munoz, Maria del Carmen Namorado-Tonix, Fanis Missirlis, Leonardo del Valle-Mondragon, Alicia Sanchez-Mendoza, Jose L. Reyes-Sanchez, Luz Graciela Cervantes-Perez
Summary: This study aims to investigate the impact of hyperglycemia on renal expression of claudins-2 and -5 in diabetic nephropathy and the role of glucose-induced oxidative stress. The results show that chronic high-glycemia levels in early stages of diabetic nephropathy decrease expression of claudins-2 and -5, increase oxidative stress, and induce MMP-activity faster than chronic middle-glycemia levels. The level of hyperglycemia plays a crucial role in the progression of diabetic nephropathy.
Article
Toxicology
W-K Lee, S. Probst, M. P. Santoyo-Sanchez, W. Al-Hamdani, I. Diebels, J-K von Sivers, E. Kerek, E. J. Prenner, F. Thevenod
ARCHIVES OF TOXICOLOGY
(2017)
Article
Multidisciplinary Sciences
Edith Sierra-Mondragon, Eduardo Molina-Jijon, Carmen Namorado-Tonix, Rafael Rodriguez-Munoz, Jose Pedraza-Chaverri, Jose L. Reyes