Review
Urology & Nephrology
Tyrone G. Harrison, Marcello Tonelli
Summary: The measurement of proteinuria is crucial for diagnosing and monitoring kidney disease, but there is still controversy and uncertainty surrounding the optimal measurement method. International guidelines recommend the use of urinary albumin-to-creatinine ratio, but this method is not universally available and can be costly. Additionally, the accuracy of different measurement methods may vary depending on the magnitude of albuminuria, sex, and clinical contexts.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Cassianne Robinson-Cohen, Jefferson L. Triozzi, Bryce Rowan, Jing He, Hua C. Chen, Neil S. Zheng, Wei-Qi Wei, Otis D. Wilson, Jacklyn N. Hellwege, Philip S. Tsao, J. Michael Gaziano, Alexander Bick, Michael E. Matheny, Cecilia P. Chung, Loren Lipworth, Edward D. Siew, T. Alp Ikizler, Ran Tao, Adriana M. Hung
Summary: By conducting a meta-analysis of genome-wide association studies, three genetic loci associated with longitudinal eGFR change have been identified, shedding light on the molecular mechanisms of eGFR decline and potentially contributing to the development of new therapeutic approaches for progressive CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Cassianne Robinson-Cohen, Jefferson L. Triozzi, Bryce Rowan, Jing He, Hua C. Chen, Neil S. Zheng, Wei-Qi Wei, Otis D. Wilson, Jacklyn N. Hellwege, Philip S. Tsao, J. Michael Gaziano, Alexander Bick, Michael E. Matheny, Cecilia P. Chung, Loren Lipworth, Edward D. Siew, T. Alp Ikizler, Ran Tao, Adriana M. Hung
Summary: The study identified three significant loci associated with longitudinal decline in eGFR, providing insights into the molecular mechanisms of eGFR decline and potential therapeutic approaches for progressive CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Nutrition & Dietetics
Massimo Cirillo, Pierpaolo Cavallo, Enrico Zulli, Rachele Villa, Rosangela Veneziano, Simona Costanzo, Sara Magnacca, Augusto Di Castelnuovo, Licia Iacoviello
Summary: The study found independent positive associations of an index of sodium intake with proteinuria and albuminuria in the population.
Article
Transplantation
Zhalaliddin Makhammajanov, Abduzhappar Gaipov, Askhat Myngbay, Rostislav Bukasov, Mohamad Aljofan, Mehmet Kanbay
Summary: Proteinuria is a well-recognized biomarker and driver of chronic kidney disease progression. Degraded and reabsorbed proteins in proximal tubular epithelial cells can cause toxicity. Proteinuria leads to kidney damage and inflammation by increasing reactive oxygen species and impairing autophagy function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Carlo Garofalo, Silvio Borrelli, Toni De Stefano, Luca De Nicola, Carlo Vita, Nicola Peruzzu, Antonella Netti, Giuseppe Conte, Michele Provenzano, Roberto Minutolo
Summary: Over the past 15 years, the phenotype of newly referred CKD patients has significantly changed with an increasing frequency of older patients and more severe disease; however, renal survival has improved, suggesting greater efficacy of nephrology care.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Supabhorn Yimthiang, David A. Vesey, Phisit Pouyfung, Tanaporn Khamphaya, Glenda C. Gobe, Soisungwan Satarug
Summary: Chronic cadmium exposure can cause kidney damage, leading to a decline in glomerular filtration rate (GFR) and tubular proteinuria. Diabetic kidney disease (DKD) is characterized by albuminuria and declining GFR, and exposure to cadmium can worsen the progression of kidney disease in diabetics. A study involving 88 diabetics and 88 controls found that even low levels of cadmium exposure were associated with tubular dysfunction and increased risk of albuminuria, especially in individuals with a higher body burden of cadmium, hypertension, and reduced eGFR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Morgan E. Grams, Aditya Surapaneni, Lawrence J. Appel, James P. Lash, Jesse Hsu, Clarissa J. Diamantidis, Sylvia E. Rosas, Jeffrey C. Fink, Julia J. Scialla, James Sondheimer, Chi-Yuan Hsu, Alfred K. Cheung, Bernard G. Jaar, Sankar Navaneethan, Debbie L. Cohen, Sarah Schrauben, Dawei Xie, Pandu Rao, Harold Feldman
Summary: This study examined the multidimensional trajectories of CKD patients and found that more advanced CKD stages were associated with a higher risk of clinical events and faster eGFR decline, but only weakly related to changes in patient-reported metrics over time.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Xiaoyang Lou, Zhi Yang, Kexia Wu, Weihong Li, Wan Hu, Ronghui Nie, Ping Tu, Peng Duan
Summary: This study aimed to analyze the correlation between serum osteoprotegerin (OPG) level and chronic kidney disease (CKD) in patients with type 2 diabetes. The results showed a negative correlation between serum OPG level and albuminuria and CKD progression risk. The study suggests that increasing OPG levels may delay the progression of CKD.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Pediatrics
Tomas Seeman, Friederike Weigel, Kveta Blahova, Filip Fencl, Stepanka Pruhova, Katharina Hermes, Richard Klaus, Barbel Lange-Sperandio, Veit Grote, Ulrike John-Kroegel
Summary: The study found that high blood pressure is present in 22% of children with RCAD syndrome and ambulatory hypertension in 14% of them.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Transplantation
Hae Hyuk Jung
Summary: This study evaluated the systolic blood pressure (BP) target for CKD patients using the Korean National Health Information Database. The findings indicate that the systolic BP target for CKD patients with proteinuria should be <= 130 mmHg, while for CKD patients without proteinuria it should be <= 140 mmHg. Moreover, the benefit of intensive BP-lowering may be greater in CKD patients, especially those with proteinuria.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Chi D. Chu, Neil R. Powe, Charles E. McCulloch, Deidra C. Crews, Yun Han, Jennifer L. Bragg-Gresham, Rajiv Saran, Alain Koyama, Nilka R. Burrows, Delphine S. Tuot
Summary: The study shows that Asian, Black, and Hispanic patients have higher performance on process measures of CKD care compared to White patients, but achievement of blood pressure and diabetes control is similar or lower among these groups.
Article
Urology & Nephrology
Jing Liu, Lise Bankir, Ashish Verma, Sushrut S. Waikar, Ragnar Palsson
Summary: The urine-to-plasma (U/ P) ratio of urea is correlated with urine-concentrating capacity and associated with the progression of autosomal dominant polycystic kidney disease. This study aimed to investigate the association between U/P urea ratio and the progression of common forms of chronic kidney disease (CKD).
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Medical Laboratory Technology
Guillaume Resimont, Laura Vranken, Hans Pottel, Francois Jouret, Jean-Marie Krzesinski, Etienne Cavalier, Pierre Delanaye
Summary: This study investigated the performance of two equations for estimating ACR from PCR in our population. The results showed good concordance between mACR and eACR, regardless of the equation or analyser used.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Endocrinology & Metabolism
Filipe A. Moura, David D. Berg, Andrea Bellavia, Jamie P. Dwyer, Ofri Mosenzon, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Itamar Raz, Mark W. Feinberg, Eugene Braunwald, David A. Morrow, Marc S. Sabatine
Summary: A risk assessment tool has been developed to identify T2D patients at higher risk for kidney disease progression and who may benefit more from SGLT2 inhibition.
Article
Surgery
Mona Ascha, Jarred McDaniel, Irene Link, David Rowe, Hooman Soltanian, Abdus Sattar, Devra Becker, Gregory E. Lakin
JOURNAL OF CRANIOFACIAL SURGERY
(2016)
Article
Rheumatology
Carol M. Greco, Amy H. Kao, Abdus Sattar, Natalya Danchenko, Kathleen M. Maksimowicz-McKinnon, Daniel Edmundowicz, Kim Sutton-Tyrrell, Russell P. Tracy, Lewis H. Kuller, Susan Manzi
Article
Nursing
Shirley M. Moore, Carol M. Musil, Anthony I. Jack, Megan L. Alder, David M. Fresco, Allison Webel, Kathy D. Wright, Abdus Sattar, Patricia Higgins
Article
Nursing
Kelly L. Wierenga, Shirley M. Moore, Jintao Liu, Abdus Sattar
REHABILITATION NURSING
(2020)
Article
Rehabilitation
Matthew Plow, Marcia Finlayson, Jintao Liu, Robert W. Motl, Francois Bethoux, Abdus Sattar
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2019)
Article
Neurosciences
WR Lariviere, MA Sattar, R Melzack
JOURNAL OF NEUROPHYSIOLOGY
(2006)