Article
Endocrinology & Metabolism
Gabriela Lupusoru, Ioana Ailincai, Bogdan Marian Sorohan, Andreea Andronesi, Camelia Achim, Georgia Micu, Andra Caragheorgheopol, Dana Manda, Mircea Lupusoru, Gener Ismail
Summary: This study found that serum suPAR levels were elevated in patients with diabetic kidney disease and were associated with diabetes duration, diabetic retinopathy, renoprotective treatment, kidney function, and proteinuria. suPAR also showed a good capacity as a biomarker for advanced renal impairment and severe histological lesions of diabetic nephropathy.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Multidisciplinary Sciences
Ester Zamarron, Ana Jaureguizar, Aldara Garcia-Sanchez, Trinidad Diaz-Cambriles, Alberto Alonso-Fernandez, Vanesa Lores, Olga Mediano, Paula Rodriguez-Rodriguez, Sheila Cabello-Pelegrin, Enrique Morales-Ruiz, Maria T. Ramirez-Prieto, Maria Isabel Valiente-Diae, Teresa Gomez-Garcia, Francisco Garcia-Rio
Summary: The study compared UACR and eGFR of DKD patients based on OSA severity, finding that severe OSA patients had higher UACR and lower eGFR. AHI and ODI were identified as independent predictors.
SCIENTIFIC REPORTS
(2021)
Article
Medical Laboratory Technology
Daniela Ceccarelli Ceccarelli, Renata Paleari, Bruno Solerte, Andrea Mosca
Summary: Diabetic nephropathy and non-diabetic kidney disease are two types of kidney diseases, with the former being associated with diabetes and the latter having other causes. Early identification of disease progression and timely intervention are crucial.
CLINICA CHIMICA ACTA
(2022)
Article
Cell Biology
Ya-Chun Han, Shi-Qi Tang, Yu-Ting Liu, Ai-Mei Li, Ming Zhan, Ming Yang, Na Song, Wei Zhang, Xue-Qin Wu, Can-Hui Peng, Hao Zhang, Shikun Yang
Summary: This study investigated the effects of the AMPK agonist metformin on mitophagy and cellular injury in renal tubular cells under diabetic conditions. The results showed that metformin ameliorated renal oxidative stress and tubulointerstitial fibrosis in HFD/STZ-induced diabetic mice by activating mitophagy through a p-AMPK-Pink1-Parkin pathway. In vitro experiments revealed that metformin promoted mitophagy in HK-2 cells under high glucose/fatty acid conditions by activating AMPK and promoting the translocation of Pink1 to mitochondria.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Yui Yamamoto, Ko Hanai, Tomomi Mori, Yoichi Yokoyama, Naoshi Yoshida, Hidekazu Murata, Tomohiro Shinozaki, Tetsuya Babazono
Summary: This study found that individuals with type 2 diabetes exhibiting non-albuminuric kidney insufficiency had a higher risk of kidney function decline, albuminuria, and all-cause mortality compared to those exhibiting preserved kidney function without albuminuria.
Article
Biochemistry & Molecular Biology
Zhou Zhou, Xue-qi Liu, Shi-qi Zhang, Xiang-ming Qi, Qiu Zhang, Benito Yard, Yong-gui Wu
Summary: Our study found that serum CN-1 concentration and activity were highest in patients with diabetic nephropathy (DN), while serum carnosine concentration was lowest. Furthermore, serum CN-1 concentration was positively correlated with uric acid and serum creatinine, and negatively correlated with serum albumin and estimated glomerular filtration rate within the DN group. Additionally, serum CN-1 concentration was positively correlated with various indicators of renal damage, suggesting its importance in the occurrence and progression of DN.
Article
Multidisciplinary Sciences
Xi Yao, Xiaoting Pei, Shuoning Fan, Xueke Yang, Yingrui Yang, Zhijie Li
Summary: This study aims to explore the relationship between abnormal renal and liver function and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). The study found that higher urine albumin and urine albumin/creatinine ratio were closely related to the occurrence of DR, and low total protein was associated with an increased risk of DR. The risk factor score was positively correlated with the risk of developing DR.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Peir-Haur Hung, Yung-Chien Hsu, Tsung-Hsien Chen, Chun-Liang Lin
Summary: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease, characterized by glomerular hyperfiltration, progressive albuminuria, and declining estimated glomerular filtration rate leading to kidney failure. Metabolic changes and programmed epigenetic modifications resulting from hyperglycemia are believed to play a role in the development of DKD, although the detailed mechanisms are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Urology & Nephrology
Edgar Lerma
Summary: Chronic kidney disease caused by diabetes is a common complication in patients with diabetes, and the traditional treatment method focuses on inhibiting the renin-angiotensin system to reduce the incidence of cardiovascular and renal diseases. However, recent studies have shown that new drugs can not only improve glycemic control in diabetic patients, but also have positive effects on cardiovascular and renal outcomes. By analyzing real-world data, this study aims to evaluate the performance of medical institutions in diagnosing and treating diabetic kidney disease.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, General & Internal
Thi Thuy Uyen Nguyen, Hyeongwan Kim, Yoon Jung Chae, Jong Hwan Jung, Won Kim
Summary: This study indicates that serum VEGF-D may be an important biomarker in patients with diabetic CKD, associated with renal dysfunction and proteinuria.
Review
Pharmacology & Pharmacy
Aqsa Ashfaq, Myriam Meineck, Andrea Pautz, Ebru Arioglu-Inan, Julia Weinmann-Menke, Martin C. Michel
Summary: A systematic review of studies on SGLT2 inhibitors in rodent models of diabetes showed that these inhibitors not only improved glycemic control but also had various beneficial effects on renal function. These nephroprotective effects were observed in different animal models of type 1 and type 2 diabetes/obesity. SGLT2 inhibitors had positive effects on lipid metabolism, blood pressure, glomerulosclerosis, renal tubular fibrosis, apoptosis, oxidative stress, and inflammation, which are important pathomechanisms for atherosclerosis and renal health. However, more data on female animals and direct comparative studies with other anti-diabetic compounds are needed.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Hyunwoo Kim, Miyeon Kim, Hwa-Young Lee, Ho-Young Park, Hyunjhung Jhun, Soohyun Kim
Summary: Diabetic nephropathy is a significant microvascular complication in diabetic patients, with current treatment options insufficient to prevent its progression. Recent studies suggest DN is an inflammatory disease, with immune cells potentially playing a role in its development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Khurrum Shahzad, Sameen Fatima, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Hamzah Khawaja, Saira Ambreen, Ahmed Elwakiel, Nora Kloeting, Matthias Blueher, Peter P. Nawroth, Peter R. Mertens, Sven Michel, Frank Jaschinski, Richard Klar, Berend Isermann
Summary: The study demonstrates that an ASO-based approach reducing CHOP expression can ameliorate DKD in mice, providing renal protection on top of ACE inhibition. Inhibition of CHOP not only improves glomerular damage, but also tubular damage. ASO therapies are a potential new approach to target maladaptive ER stress signaling and improve DKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
J. David Smeijer, Donald E. Kohan, David J. Webb, Neeraj Dhaun, Hiddo J. L. Heerspink
Summary: Endothelin receptor antagonists show significant kidney protection in patients with diabetic kidney disease, with potential therapeutic effects in non-diabetic kidney diseases such as IgA nephropathy and FSGS.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Article
Clinical Neurology
Mayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yohei Doi, Adnan I. Qureshi, Sohei Yoshimura, Kaori Miwa, Akiko Ishigami, Masayuki Shiozawa, Katsuhiro Omae, Masafumi Ihara, Kazunori Toyoda
Summary: Renal impairment may lead to unfavorable outcomes following intracerebral hemorrhage, and there is a significant interaction between decreased eGFR and treatment assignment in intensive blood pressure control therapy, raising safety concerns.
Article
Endocrinology & Metabolism
Manel Mata-Cases, Bogdan Vlacho, Jordi Real, Ramon Puig-Treserra, Magdalena Bundo, Josep Franch-Nadal, Didac Mauricio
Summary: This study assessed the trends in cardiovascular risk factor control and drug therapy in patients with type 2 diabetes mellitus from 2007 to 2018. The study found improvements in blood pressure and lipid control, but an insufficient achievement of glycemic targets. The use of antidiabetic and cardiovascular drugs increased, but the proportion of patients achieving all three targets remained low and plateaued after 2013.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Anna Ramirez-Morros, Josep Franch-Nadal, Jordi Real, Monica Gratacos, Didac Mauricio
Summary: Women with T2DM have a 40% higher risk of CVD compared to men due to the interaction between sex and gender factors. There are significant differences between women and men in the management and control of CVRF, with women less likely to achieve recommended targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Suping Ling, Francesco Zaccardi, Bogdan Vlacho, Ping Li, Jordi Real Gatius, Manel Mata-Cases, Josep Franch-Nadal, Mikhail N. Kosiborod, Clare Gillies, Peter Fenici, Didac Mauricio, Baiju R. Shah, Kamlesh Khunti
Summary: This study aimed to understand the geographical and temporal patterns in the excess mortality risk associated with type 2 diabetes (T2D) in three high-income countries. The results showed similar diabetes gaps between Ontario and England, particularly in elderly subjects, while Catalonia had lower mortality rates in men with T2D from the age of 60 years.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Angels Mollo, Bogdan Vlacho, Monica Gratacos, Manel Mata-Cases, Esther Rubinat, Anna Berenguera, Jordi Real, Ramon Puig-Treserra, Xavier Cos, Josep Franch-Nadal, Kamlesh Khunti, Didac Mauricio, INTEGRA Res grp
Summary: A specially designed multicomponent healthcare intervention can improve glycaemic control in subjects with poorly controlled type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Didac Mauricio, Bogdan Vlacho, Emilio Ortega, Xavier Cos-Claramunt, Manel Mata-Cases, Jordi Real, Berta Fernandez-Camins, Josep Franch-Nadal
Summary: The aim of this study was to estimate the incidence and risk factors for fatal and non-fatal events among COVID-19 infected subjects with obesity or diabetes during the initial three epidemiological waves in the region. A retrospective cohort study was conducted using a primary care database to identify individuals with COVID-19, stratifying them based on diabetes mellitus or obesity. Results showed that fatal events were more common among individuals with diabetes, particularly during the first wave. The number of study events decreased in the second and third waves. Diabetes was found to be a risk factor for fatal events, while obesity was only a risk factor when adjusted for age, sex, diabetes, and COVID-19 waves. HIV, cancer, and autoimmune diseases were also identified as risk factors for mortality among subjects with COVID-19 in the fully-adjusted model.
PRIMARY CARE DIABETES
(2023)
Article
Endocrinology & Metabolism
Maria Teresa Julian, Silvia Ballesta, Guillem Pera, Alejandra Perez-Montes de Oca, Berta Soldevila, Llorenc Caballeria, Rosa Morillas, Carmen Exposito, Alba Martinez-Escude, Manel Puig-Domingo, Josep Franch-Nadal, Pere Toran, Kenneth Cusi, Josep Julve, Didac Mauricio, Nuria Alonso
Summary: This study investigated longitudinal changes in liver stiffness measurement (LSM) in the general adult population without known liver disease and found that abdominal obesity and dysglycemia were the main risk metabolic factors associated with the development of moderate-to-advanced liver fibrosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Violeta Antonio-Arques, Joan A. Cayla, Jordi Real, Antonio Moreno-Martinez, Angels Orcau, Didac Mauricio, Manel Mata-Cases, Josep Julve, Elena Navas Mendez, Rai Puig Treserra, Joan Pau Millet, Jose Luis Del Val Garcia, Bogdan Vlacho, Josep Franch-Nadal
Summary: The glycemic control of diabetic patients is associated with an increased risk of developing tuberculosis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Orthopedics
Magdalena Bundo, Bogdan Vlacho, Judit Llussa, Isabel Bobe, Meritxell Aivar, Carmen Ciria, Ana Martinez-Sanchez, Jordi Real, Manel Mata-Cases, Xavier Cos, Montserrat Doria, Jordi Viade, Josep Franch-Nadal, Didac Mauricio
Summary: This study evaluated the prognosis of diabetic foot ulcer (DFU) in primary care centers in Catalonia, Spain, over a 12-month period. The results showed high mortality, amputation, and recurrence rates, and low healing rate among patients with DFU. Diabetes complications and high PEDIS/SINBAD scores were associated with poor clinical outcomes.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Marina Idalia Rojo-Lopez, Marcelino Bermudez-Lopez, Eva Castro, Cristina Farras, Gerard Torres, Reinald Pamplona, Albert Lecube, Jose Manuel Valdivielso, Elvira Fernandez, Josep Julve, Esmeralda Castelblanco, Josep Franch-Nadal, Nuria Alonso, Minerva Granado-Casas, Didac Mauricio
Summary: The aim of this study was to evaluate the association between the Mediterranean diet and subclinical atherosclerotic disease. The results showed that higher adherence to the Mediterranean diet was associated with a lower risk of atherosclerotic plaques, and moderate or high adherence to the diet was associated with a lower number of plaques.
Article
Endocrinology & Metabolism
Angels Mollo, Bogdan Vlacho, Monica Gratacos, Manel Mata-Cases, Esther Rubinat, Anna Berenguera Osso, Francesc Xavier Cos, Josep Franch-Nadal, Kamlesh Khunti, Didac Mauricio
Summary: The INTEGRA study aimed to evaluate the effectiveness of a specially designed multicomponent health care intervention in improving glycaemic control in poorly controlled type 2 diabetes patients. The intervention group showed a significant reduction in HbA1c values compared to the usual care group at 12 months, and more patients in the intervention group achieved target blood glucose levels.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Sergio Valdes, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Eva Garcia-Escobar, Sara Garcia-Serrano, Wasima Oualla-Bachiri, Marta Garcia-Vivanco, Juan Luis Garrido, Victoria Gil, Fernando Martin-Llorente, Alfonso Calle-Pascual, Luis Castano, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbes, F. Javier Chaves, Jose L. Galan-Garcia, Gabriel Aguilera-Venegas, Joan Carles Vallve, Nuria Amigo, Montse Guardiola, Josep Ribalta, Gemma Rojo-Martinez
Summary: The study aimed to assess the associations between exposure to air pollutants and lipoprotein measures in the adult population of Spain. The results showed that exposure to particulate matter and nitrogen dioxide was associated with lower levels of high-density lipoprotein cholesterol and particles, as well as increased risk of low high-density lipoprotein cholesterol and particles. Subgroup analysis further revealed that the effects of particulate matter and nitrogen dioxide were more pronounced in men and individuals with obesity.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Pedro Romero-Aroca, Raquel Verges, Jordi Pascual-Fontanilles, Aida Valls, Josep Franch, Joan Barrot, Xavier Mundet, Alex La Torre, Antonio Moreno, Ramon Sagarra, Josep Basora, Eugeni Garcia-Curto, Marc Baget-Bernaldiz
Summary: This study found that arterial hypertension, high HbA1c levels, microalbuminuria, high LDL-cholesterol, high TC/HDL-C index, high non-HDL-C/HDL-C index, the use of statins, and high body mass index are the main factors influencing the development of diabetic retinopathy. Conversely, high HDL-cholesterol levels and the use of fibrates have a protective effect.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Olga Simo-Servat, Judit Amigo, Monica Sanchez, Carla Morer, Josep Franch-Nadal, Regina Mayor, Tim Snel, Rafael Simo, Cristina Hernandez
Summary: This study evaluated the efficacy of self-management of insulin titration based on information received by the Short Message Service (SMS). The results showed that SMS-guided titration improved glycemic control and significantly improved psychological aspects related to insulin treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)