Article
Chemistry, Multidisciplinary
Harsh Jain, Dipankar Sutradhar, Sourav Roy, Gautam R. Desiraju
Summary: Higher cocrystal synthesis relies heavily on understanding supramolecular synthons, taking into account the electrophilicity/nucleophilicity differences between alternative sites of halogen bond formation, and ensuring that the two halogen bonds in a ternary halogen bonded cocrystal have different strengths. Mimicking hydrogen bond interactions with halogen bonds is a feasible approach for ternary structures, as shown with the pyrene example. Crystal engineers should be able to predict halogen bonds that are stronger than hydrogen bonds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yu-Jie Zhu, Ya Gao, Min-Min Tang, Julius Rebek, Yang Yu
Summary: Supramolecular capsules are nanoscale containers used for studying molecular behavior, with practical applications in various fields. Self-assembly is an effective approach in constructing these capsules, utilizing noncovalent interactions. Bowl-shaped cavitand structures made from resorcinarenes have advantages for building supramolecular capsules, especially when held together by unconventional halogen and chalcogen bonds.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Nikola Bedekovic, Luka Fotovic, Vladimir Stilinovic, Dominik Cincic
Summary: Seven cocrystals of pyridone and perfluorinated halocarbons have been prepared, and the pyridone homosynthon is found to be a robust and reliable supramolecular synthon in these cocrystals.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Shuguo An, Aiyou Hao, Pengyao Xing
Summary: This study reports a series of halogen-bonded dimeric complexes with axial chirality formed by noncovalent bonds. The introduced halogen bond allows the material to have dynamic tunability and adaptivity, and can be a powerful tool for constructing functional axial chiral compounds.
Review
Chemistry, Multidisciplinary
Carsten Praesang, Duncan W. Bruce
Summary: This article discusses the application of the halogen bond in the preparation of liquid crystal materials, focusing on successful examples of deployed motifs. By comparing with hydrogen-bonded materials, the article examines how the lability and flexibility of the halogen bond manifest in liquid crystal behavior.
HELVETICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Chuan-Zhi Liu, Jing-Jing Wang, Bo Yang, Zhong-Yi Li, Meng Yan, Xin-Ming Liu, Zhi-Yuan Hu, Lan-Tao Liu, Zhan-Ting Li
Summary: This paper selectively constructed two types of 2D and 3D XBOFs by changing the crystallization solvent. These XBOFs were formed from identical building blocks and the 3D XBOF is a novel hybrid supramolecular organic framework with synergistic control of hydrogen and halogen bonds.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Chuan-Zhi Liu, Jing-Jing Wang, Bo Yang, Zhong-Yi Li, Meng Yan, Xin-Ming Liu, Zhi-Yuan Hu, Lan-Tao Liu, Zhan-Ting Li
Summary: In this study, two types of solid phase 2D and 3D XBOFs were selectively constructed from identical building blocks by changing the crystallization solvent. The novel 3D XBOF formed in this process is a hybrid supramolecular organic framework that combines the control of hydrogen and halogen bonds. The selective construction of two types of 2D and 3D XBOFs was achieved by altering the crystallization solvent.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jiri Czernek, Jiri Brus
Summary: The study investigated a tetramer model of a remarkably stable iodine-containing supramolecular capsule using a DFT computational model to decompose total stabilization energy. It was found that the significant enthalpic gain associated with the formation of investigated tetramers, and the total stabilization of these complexes is dominated by binary interactions.
Article
Chemistry, Multidisciplinary
Lavanya Kumar, Katarina Leko, Vinko Nemec, Damian Trzybinski, Nikola Bregovic, Dominik Cincic, Mihails Arhangelskis
Summary: Periodic DFT calculations were used to predict the stability and interconversion of halogen-bonded cocrystals. The results aligned well with experimental findings, demonstrating the capability of periodic DFT in designing solid-state mechanochemical reactions. Additionally, the calculated DFT energies were compared with experimental dissolution calorimetry measurements, providing a benchmark for the accuracy of periodic DFT calculations in modeling transformations of halogen-bonded molecular crystals.
Article
Chemistry, Multidisciplinary
Ning Xia, Jiahao Zhao, Guanfei Gong, Hongqiang Dong, Haohu Li, Jike Wang, Lu Wang, Shigui Chen
Summary: In this study, chiral supramolecular 2D halogen-bonded organic frameworks (XOFs) were constructed through a post-synthetic modification strategy. Chiral α/β-cyclodextrins (α/β-CD) were successfully introduced, resulting in the fabrication of chiral supramolecular 2D XOFs.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
J. Mikko Rautiainen, Maryna Green, Minna Mahonen, Jani O. Moilane, Manu Lahtinen, Arto Valkonen
Summary: Halogen bonding interactions were studied in 15 crystalline 3-iodopyridinium systems. Experimental results showed that halogen bonding acts as a secondary intermolecular force in these charged systems, while still maintaining high directionality of interaction. Computational studies validated the experimental data and showed that halogen bond strengths were exaggerated in smaller model systems, but improved agreement between experimental and calculated structures was seen in larger systems. The strength of halogen bonds was found to come second to electrostatic interactions in stabilizing structures, but played a major role in directing the packing of solid-state structures.
CRYSTAL GROWTH & DESIGN
(2023)
Review
Chemistry, Physical
Veronica Iuliano, Paolo Della Sala, Carmen Talotta, Margherita De Rosa, Annunziata Soriente, Carmine Gaeta, Placido Neri
Summary: The confinement of substrates inside self-assembled capsules allows for effective catalysis of organic reactions similar to enzymes in biological systems. Chemical reactions in confined spaces exhibit unique processes due to steric constraints, solvent exclusion, intermediates stabilization, and conformational control of substrates, often breaking the fundamental rules of organic reactivity. This review focuses on the hexameric capsule CR, a supramolecular assembly of six resorcinarene 1 macrocycles and eight water molecules, which has shown effective catalysis of various chemical reactions by controlling reactivity and selectivity in its confined space.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Elena Vulpe, Sylvain Grosjean, Zahid Hassan, Veronique Bulach, Mir Wais Hosseini, Stefan Brase
Summary: A series of halogen-bonded discrete, one-dimensional supramolecular architectures were prepared by co-crystalizing a sterically hindered class of homologous ditopic para-xylenes with mono-, di-, and triiodofluorobenzene. The solid-state structures investigated by X-ray diffraction show that the molecular geometry of the tectons and halogen bond directionality translates into corresponding XB cocrystals with a conformational twist at the planes of para-xylene. The bipyridine tectons grafted with photo-responsive azobenzene side-group can be remotely modulated by light in the halogen-bonded chains, offering innovative applications possibilities.
Article
Chemistry, Multidisciplinary
Shilin Yu, Khai-Nghi Truong, Marcel Siepmann, Arto Siiri, Christian Schumacher, Jas S. Ward, Kari Rissanen
Summary: A series of LH[Z-I-Z] halogen(I) complexes were synthesized and characterized. These complexes consist of a [N-I-N]- anion with a three-center-four-electron (3c-4e) halogen bond, and a hydrogen bonding or inert cation. The symmetric [N-I-N]- anion is structurally equivalent to its cationic analogue [N-I-N]+. However, the [N-I-N]- complexes with a hydrogen bond to only one saccharinato moiety showed asymmetry in the N-I bond lengths, similar to the asymmetric heteroleptic [N-I-N]+ complexes.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Shuguo An, Aiyou Hao, Pengyao Xing
Summary: In this work, the [N center dot center dot center dot I center dot center dot center dot N]+ halogen bond was utilized to drive the formation of supramolecular helical polymers, showing tunable supramolecular chirality. Multiple protocols in regulating helicity were provided by ion exchange and solvent environments.
Article
Chemistry, Applied
Peng Wu, Jas S. Ward, Kari Rissanen, Carsten Bolm
Summary: Copper-catalyzed cross-coupling reactions of alpha-bromoaryl NH-sulfoximines with elemental sulfur were used to synthesize benzo[d][1,3,2]dithiazole-1-oxides, which belong to a new class of three-dimensional heterocycles. The reactions exhibited good functional group and heterocycle tolerance under mild conditions. Moreover, the initial cross-coupling products could be converted to unprecedented cyclic sulfonimidamides derivatives through imination/oxidation. Additionally, a seven-membered heterocycle was obtained by a ruthenium-catalyzed ring-expansion with ethyl propiolate.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Christian Schumacher, Jas S. Ward, Kari Rissanen, Carsten Bolm, Mohamed Ramadan El Sayed Aly
Summary: Cholesterol can react under Appel conditions to form 3,5-cholestadiene and 313-bromocholest-5-ene, which deviates from the stereochemistry of the standard Appel mechanism due to the involvement of A5 pi-electrons. However, the subsequent azidolysis of 313-bromocholest-5-ene proceeds mainly by Walden inversion, resulting in the formation of 3a-azidocholest-5-ene. The structures of the products were confirmed by X-ray crystallography and the NMR data matched the reported data.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rene Hommelsheim, Sandra Bausch, Arjuna Selvakumar, Mostafa M. Amer, Khai-Nghi Truong, Kari Rissanen, Carsten Bolm
Summary: Copper(I)-catalyzed domino reactions of 2-azido sulfoximines with 1-iodoalkynes afford fused triazolyl-containing benzothiadiazine-1-oxides in one step with high yields. This method exhibits broad functional group tolerance and allows the synthesis of two fused heterocyclic rings. Mechanistic investigations reveal the involvement of a copper pi-complex and an iodinated triazole intermediate in the reaction sequence.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jas S. Ward, Elina I. Sievanen, Kari Rissanen
Summary: Solid-state NMR was used to study a series of Barluenga-type iodine(I) [L-I-L]PF6 complexes (L=pyridine, 4-ethylpyridine, 4-dimethylaminopyridine, isoquinoline) and their respective non-liquid ligands (L), precursor silver(I) complexes, and N-methylated pyridinium and quinolinium hexafluorophoshate salts. The results were compared to solution studies and single-crystal X-ray structures. Practical considerations were discussed to encourage wider utilization of this technique in the future as the first study of its kind on the solid-state NMR behavior of halogen(I) complexes.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kwaku Twum, Sanaz Nadimi, Frank Boateng Osei, Rakesh Puttreddy, Yvonne Bessem Ojong, John J. Hayward, Kari Rissanen, John F. Trant, Ngong Kodiah Beyeh
Summary: In this study, the formation of a three-component halogen-bonded ternary assembly in a protic polar solvent system is achieved by utilizing the binding of fused aromatic N-heterocycles in an open resorcinarene cavity to template the assembly. This approach overcomes the challenges posed by the overwhelming quantity of competing solvent.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Maike Lettow, Kim Greis, Eike Mucha, Tyler R. Lambeth, Murat Yaman, Vasilis Kontodimas, Christian Manz, Waldemar Hoffmann, Gerard Meijer, Ryan R. Julian, Gert von Helden, Mateusz Marianski, Kevin Pagel
Summary: Fucose is a signaling carbohydrate attached to the end of glycan processing. It has various roles in processes like leukocyte adhesion and pathogen-receptor interactions. However, the presence of fucose-containing chimeric fragments in mass-spectrometric analysis has complicated the determination of glycans' structure. In this study, various techniques were used to deduce the rearrangement product of fucose in model trisaccharides Lewis x and blood group H2, with the most likely product being fucose attached to galactose through an alpha(1 -> 6) glycosidic bond.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Plant Sciences
Emanuel T. Mahambo, Colores Uwamariya, Masum Miah, Leandro da Costa Clementino, Luis Carlos Salazar Alvarez, Gabriela Paula Di Santo Meztler, Edward Trybala, Joanna Said, Lianne H. E. Wieske, Jas S. Ward, Kari Rissanen, Joan J. E. Munissi, Fabio T. M. Costa, Per Sunnerhagen, Tomas Bergstrom, Stephen S. Nyandoro, Mate Erdelyi
Summary: Six new crotofolane diterpenoids (1-6) and 13 known compounds (7-19) were isolated from Croton kilwae. The structures of the new compounds were determined by analyzing spectroscopic and mass spectrometric data. Some of the compounds exhibited antiviral, antibacterial, and antimalarial activities.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Organic
Kim Greis, Caleb E. Griesbach, Carla Kirschbaum, Gerard Meijer, Gert von Helden, Kevin Pagel, Mark W. Peczuh
Summary: Ferrier reactions involve Lewis acid activation of a cyclic enol ether to generate a glycosyl Ferrier cation through the departure of an allylic leaving group. The resulting cation undergoes attack and transposition, forming a new acetal linkage. This study focuses on the septanosyl Ferrier cation derived from a seven-membered ring carbohydrate-based oxepine. Experimental characterization of the ion, including gas-phase cryogenic IR spectroscopy and solution-phase Ferrier reactions, reveals a preference for contraction to five-membered ring structures in the cation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Xianliang Wang, Kari Rissanen, Carsten Bolm
Summary: N-Trifluoroacetylated (N-TFA) sulfoximines react with 1-trifluoromethylstyrenes in a one-pot domino reaction to give fluorinated 5,6-dihydro-1,2-thiazine 1-oxides in good to high yields. The process involves three sequential reaction steps that can be characterized as (1) nucleophilic allylic substitution (S(N)2 '), (2) hydrolysis, and (3) intramolecular nucleophilic vinylic substitution (SNV). The products can further be modified by defluorination. The molecular structure of the resulting product was confirmed by X-ray crystallographic analysis.
Article
Chemistry, Multidisciplinary
Teresa M. Karl, Samir Bouayad-Gervais, Julian A. Hueffel, Theresa Sperger, Sebastian Wellig, Sherif J. Kaldas, Uladzislava Dabranskaya, Jas S. Ward, Kari Rissanen, Graham J. Tizzard, Franziska Schoenebeck
Summary: Due to the unknown correlation between a metal's ligand and its resulting preferred speciation in terms of oxidation state, geometry, and nuclearity, the rational design of multinuclear catalysts is still challenging. In this study, we employed an assumption-based machine learning approach to accelerate the identification of suitable ligands for trialkylphosphine-derived dihalogen-bridged Ni-(I) dimers. We experimentally verified the predictions, synthesized novel Ni-(I) dimers, and explored their potential in catalysis, achieving C-I selective arylations of polyhalogenated arenes with competing C-Br and C-Cl sites in under 5 min at room temperature using the newly developed dimer, [Ni-(I)(& mu;-Br)PAd(2)(n-Bu)](2), which has not been met with alternative dinuclear or mononuclear Ni or Pd catalysts so far.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemical Research Methods
Michael Goetze, Lukasz Polewski, Leila Bechtella, Kevin Pagel
Summary: This article introduces a 3D-printable nano-electrospray ionization (nano-ESI) source for Bruker instruments, which can be assembled by anyone with access to a 3D printer. The source can be fitted to any Bruker mass spectrometer with an ionBooster ESI source and only requires minor, reversible changes to the original Bruker hardware. The general utility of the source was demonstrated by recording high-resolution MS spectra of small molecules, intact proteins, as well as complex biological samples in negative and positive ion mode on two different Bruker instruments.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Chemistry, Organic
Yiwei Gong, Jas S. Ward, Kari Rissanen, Florian F. Mulks
Summary: Site-selective functionalization of pyridines is crucial for the synthesis of pharmaceuticals and materials. We introduce diiminium pyridine adducts as convenient and potent Lewis acids, and report the selective addition of tributylphosphine to the 4-position of pyridine. This finding advances the utilization of diiminium units as organic reagents or catalysts for pyridine functionalization. Computational models provide valuable insights for future investigations in this area.
Article
Chemistry, Multidisciplinary
Rene Hommelsheim, Sandra Bausch, Robin van Nahl, Jas S. Ward, Kari Rissanen, Carsten Bolm
Summary: A variety of 3-amino-substituted benzothiadiazine oxides were synthesized via a one-step palladium-catalyzed cascade reaction of 2-azido sulfoximines with isonitriles. The desired heterocycles were obtained in good to excellent yields using very low catalyst loadings and short reaction times. This protocol provides direct access to precursors for pharmaceutically relevant sulfoximines.
Article
Chemistry, Multidisciplinary
Milla Mattila, Kari Rissanen, Jas S. Ward
Summary: Three chiral carbonyl hypoiodites were synthesized from N-protected (S)-valine and formed ligand-stabilised (S)-valinoyl hypoiodite complexes with 4-dimethylaminopyridine, 4-pyrrolidinopyridine, and 4-morpholinopyridine as stabilising ligands. The structures of the complexes were determined through NMR (H-1, C-13, H-1-N-15 HMBC) and single crystal X-ray diffraction analysis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ahed Almalla, Laura Elomaa, Lei''la Bechtella, Assal Daneshgar, Prabhu Yavvari, Zeinab Mahfouz, Peter Tang, Beate Koksch, Igor Sauer, Kevin Pagel, Karl Herbert Hillebrandt, Marie Weinhart
Summary: In this study, the potential of proteolytic enzymes including pepsin, papain, alpha-amylase, and collagenase to solubilize porcine liver dECM was compared. Papain, a plant-derived enzyme, was found to be a cost-effective alternative to animal-derived pepsin for dECM solubilization. Papain-digested dECM preserved its thermally triggered gelation properties similar to pepsin-digested dECM, and the resulting hydrogels demonstrated enhanced bioadhesiveness.
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.
