Article
Chemistry, Analytical
Rui Duan, Chao Peng, Lu Sun, Lu-Xia Zhang, Chen-Chen Bai, Lin-Yi Dong, Xian-Hua Wang
Summary: By integrating boronate affinity controllable-oriented surface imprinting nylon wire and allochroic-graphene oxide, a fast, sensitive, and specific detection method for glycoproteins has been developed. This method offers lower limit of detection, wider linear range, lower cost, less time-consuming, and reusability compared to traditional methods, demonstrating great potential for various applications including early clinical cancer diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Jin-Ye Lang, Chen-Chen Bai, Shi-Song Yu, Meng-Ying Chen, Lin-Yi Dong, Zhen-Yu Zhao, Xian-Hua Wang
Summary: By integrating boronate-affinity-oriented and sequential surface imprinting, boronate-affinity-oriented and sequential-surface imprinting magnetic nanoparticles (BSIMN) were fabricated. The BSIMN exhibited excellent selectivity towards glycoprotein templates and was successfully applied in quantitative detection of glycoproteins.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Lu-Xia Zhang, Rui Duan, Yuan-Shuo Yang, Chao Peng, Lin-Yi Dong, Xian-Hua Wang
Summary: The method relies on a dual boronate-affinity sandwich strategy for specific and ultrasensitive detection of ellagic acid, utilizing boronate-affinity-related molecularly imprinted recognition and boronate-affinity recognition. The approach shows a linear relationship between allochroic signal readout and the logarithm of EA concentration, with a good correlation coefficient and a low limit of detection. Additionally, it has been successfully applied in the detection of EA concentration in spiked strawberry samples with satisfactory recovery and relative standard deviation.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Xing-Hui Ren, Hai-Yan Wang, Si Li, Xi-Wen He, Wen-You Li, Yu-Kui Zhang
Summary: In this study, Gal-NAc-imprinted nanoparticles were synthesized using a boronate-affinity glycan-oriented surface imprinting strategy. Molecularly imprinted polymers were hybridized with fluorescent silicon nanoparticles for highly sensitive fluorescence and magnetic resonance imaging. The synthesized nanoparticles showed desirable performance in dual-model imaging for specific targeting of cancer cells, with potential in real biological samples.
Article
Chemistry, Analytical
Yi Luo, Chen-Chen Bai, Ming-Xia Liu, Di Wang, Meng-Ying Chen, Shi-Song Yu, Xin-Ying Bu, Xian-Hua Wang
Summary: The study successfully integrated boronate-affinity-oriented surface imprinting and PEGylation to fabricate PBSIMN for HRP detection, demonstrating improved adsorption capacity and rate. This integration provided ultrahigh sensitivity with a significantly lower limit of detection compared to non-PEGylated materials, indicating the potential of this combined approach for enhancing the performance of imprinted materials.
Article
Chemistry, Analytical
Haibo He, Yishan Wang, Ziqing Zhou, Yue Guo, Xiaoxia Yan, Yunyi Lei, Xia Shen, Wanjun Liu, Liqiang Luo
Summary: A facile method utilizing boronate affinity was developed for preparing adenosine molecularly imprinted materials with excellent recognition selectivity and specificity. The obtained material was successfully applied as a selective solid-phase extractant for the determination of adenosine and guanine, showing good recovery rates and stability.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Xue Zhang, Qin Wei, Xin Meng, Lili Zhao, Zhaosheng Liu, Yanping Huang
Summary: A new strategy utilizing a dendrimer-like structure of boron materials based on octavinyl-polyhedral oligomeric silsesquioxanes (Ov-POSS) was suggested to improve boronate avidity with good accessibility of sites. The resulting Ov-POSS cross-linked boron monolith showed significantly stronger affinity for glycoproteins compared to the Ov-POSS-free monolith. The developed microfluidic platform, which integrated multiple functions, demonstrated high efficiency and high-throughput analysis for post-translational modification proteomics.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jing Chen, Liangwen Hao, Jiaqi Hu, Kang Zhu, Yu Li, Sicheng Xiong, Xiaolin Huang, Yonghua Xiong, Ben Zhong Tang
Summary: A universal boronate-affinity crosslinking-amplified DLS immunoassay was developed for point-of-care glycoprotein detection, achieving ultrasensitive and rapid quantitative assay within 15 minutes. This approach combines antibody-coated magnetic nanoparticles for target capture and DLS signal transduction with phenylboronic acid-based boronate-affinity materials as crosslinking amplifiers, making it a promising strategy for extending DLS technique to detect glycoproteins even in challenging environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Ting Pan, Yali Lin, Quanzhou Wu, Kaiwen Huang, Jianfeng He
Summary: This study proposed a facile strategy for the preparation of surface molecularly imprinted polymer microspheres using boronate affinity and polydopamine coating, showing good imprinting efficiency towards the glycoside template naringin. The surface imprinted microspheres were successfully utilized as sorbents for the solid phase extraction of naringin from Citri Grandis extract, achieving a high recovery rate of 84.4%.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Biophysics
Yi Sun, Yi Luo, Lu Sun, Xiao-Rui Wang, Li-Wei Chen, Ning Zhang, Yu Wang, Lin-Yi Dong, Hua Guo, Xian-Hua Wang
Summary: We developed an innovative PEGylated boronate affinity cell imprinted polydimethylsiloxane (PBACIP) system for efficient capture and release of circulating tumor cells (CTCs) from cancer patients. The system achieved high selectivity and capture efficiency through the synergistic effect of boronate affinity and cell imprinting, without the use of antibodies. The captured CTCs can be released for downstream analysis.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Shucheng Liu, Nana Tang, Xuan Zhang, Hao Huang, Jinyu Li, Hongxiang Ou
Summary: Porous hydrophilic boronate affinity imprinted hydrogels (POHBA-MIPs) were successfully fabricated using a one-step RAFT Pickering HIPEs emulsion imprinting method. The hydrogels exhibited strong binding affinity and selectivity, making them suitable for the specific separation and purification of naringin.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Chemistry, Analytical
Zijun Bie, Yang Chen
Summary: An IFN-alpha specific plastic antibody was prepared using boronate affinity oriented surface imprinting, showing strong affinity and high specificity for selective enrichment of IFN-alpha. This plastic antibody has potential applications in the pharmaceutical industry.
Article
Nanoscience & Nanotechnology
Yao Zhu, Ke Wang, Jiahui Lu, Zhiyuan Pan, Jian Rong, Tao Zhang, Dongya Yang, Jianming Pan, Fengxian Qiu
Summary: The study demonstrates a new strategy for preparing boronate affinity molecularly imprinted hollow carbon fibers through electrospinning technique with selective binding sites for shikimic acid. These fibers exhibit high adsorption capacity and stability, showing strong affinity and selectivity towards shikimic acid.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Zixuan Liu, Zheng-Zhi Yin, Wenrong Cai, Datong Wu, Junyao Li, Yong Kong
Summary: A surface protein-imprinted biosensor was developed for the detection of anti-IgG. The biosensor showed a wide linear range, low detection limit, high selectivity, reproducibility, and stability.
Article
Engineering, Chemical
Danqing Shen, Xueping Chen, Jialu Luo, Yaxin Wang, Yonghui Sun, Jianming Pan
Summary: The research presents a new method to prepare efficient sorbents for pollutant uptake in water using Janus nanosheets. By selectively grafting imprinted polymers onto one side of Janus nanosheets, the efficient sorptive extraction of catechol can be achieved. NS-1-MIPs show excellent adsorption performance and regeneration capability.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Pengfei Li, Jilei Pang, Shuxin Xu, Hui He, Yanyan Ma, Zhen Liu
Summary: Researchers have developed a dual-modal ratiometric immunoassay based on MIPs for precise diagnosis of hepatocellular carcinoma (HCC). This assay exhibits improved precision compared to traditional ELISA, providing a glycoform-resolved method for HCC diagnosis and a new paradigm for developing antibody mimics via molecular imprinting.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Shuxin Xu, Hui He, Zhen Iiu
Summary: The development of biomimetic affinity materials has significant value in both scientific research and practical applications. By using boronic acid chemistry, a series of boronate affinity materials (BAMs) with desired binding properties have been developed. MIPs and aptamers based on BAMs have been designed and prepared for targeting vital biomolecules. These affinity reagents, combined with advanced analytical techniques, have enabled the construction of promising analytical methods for challenging applications, such as targeted proteomics analysis, single cell analysis, and disease diagnostics. Additionally, the targeting capability of nanoscale MIPs has provided a unique approach for the development of innovative nanotherapeutics for cancer treatment.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Xinpei He, Qi Luo, Zhanchen Guo, Ying Li, Zhen Liu
Summary: This study presents a new strategy for the rational design and preparation of molecularly imprinted mesoporous silica nanoparticles that can mimic the functions of enzymes. This strategy enhances the effective collision probability of substrates and enables continuous product amplification through thermal cycling. As a result, the reaction speed is significantly improved and sequence specificity is enhanced.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Rongrong Xing, Zhanchen Guo, Haifeng Lu, Qi Zhang, Zhen Liu
Summary: Molecularly imprinted polymers (MIPs) are important antibody mimics, but the current molecular imprinting technology faces a compromise between affinity and specificity. This study presents a new strategy called molecular imprinting and cladding (MIC), which improves the affinity and specificity of MIPs by generating a chemically inert cladding layer. The proposed strategy and method were successfully applied to engineer protein binders and demonstrated potential applications in disease diagnosis and nanomedicine.
Article
Chemistry, Analytical
Yanyan Ma, Zhanchen Guo, Chuanwen Fan, Jingran Chen, Shuxin Xu, Zhen Liu
Summary: This study developed aptamers that can target ABCG2 and reverse multidrug resistance, showing great potential in cancer diagnosis and treatment. The aptamers can specifically bind to human colorectal cancer stem cells and effectively reverse drug resistance in liver cancer cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Jin Ye, Mengyao Zheng, Haihua Ma, Zhihong Xuan, Wei Tian, Hongmei Liu, Songxue Wang, Yuan Zhang
Summary: A chromatography-free method for the detection of AFB(1) in cereals and oils using quantum dots and immunomagnetic beads coupled with AAS has been developed. This method exhibited high sensitivity, low detection limits, and a wide linear dynamic range. The recoveries for different food matrices were high with low standard deviations. The method was successfully applied to various food samples and showed comparable results to liquid chromatography-tandem mass spectrometry. This method provides a new route for the detection of mycotoxins through AAS and expands the application scope of AAS, making it useful for simultaneous determination of multiple poisonous compounds.
Article
Agriculture, Multidisciplinary
Baoxia Ni, Jin Ye, Jinnan Chen, Li Li, Hongmei Liu, Yu Wu, Songxue Wang
Summary: This study proposes an environmentally friendly and automated pretreatment method for the detection and analysis of mycotoxins in peanut oil. The method efficiently cleans and concentrates aflatoxins without the need for centrifugation or filtering steps, and virtually no organic waste is produced. Coupled with ultra-performance liquid chromatography-fluorescence detection, the method offers a reliable detection approach.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Jian Ji, Heyang Huang, Li Li, Jin Ye, Jiadi Sun, Lina Sheng, Yongli Ye, Yi Zheng, Zhijie Zhang, Xiulan Sun
Summary: This study utilized solid-phase microextraction combined with full two-dimensional gas chromatography time-of-flight mass spectrometry to detect volatile organic compounds (VOCs) produced by F. graminearum during wheat infestation. The results showed that VOCs emitted by F. graminearum can differentiate strains at different growth stages and are correlated with the composition of fungal flora and mycotoxin production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Wei Tian, Yonglin Liu, Songxue Wang, Jin Ye, Hongmei Liu, Yue Wang, Minghui Zhou
Summary: A high-throughput and automatic magnetic solid-phase extraction method was developed for the rapid and accurate analysis of five heavy metals in cereals and feeds. The method achieved purification and enrichment of the heavy metals within 8 minutes and could process up to 24 samples simultaneously in less than 22 minutes. The developed method showed good agreement with traditional standard microwave digestion and had high precision, safety, and reliability.
Article
Agriculture, Multidisciplinary
Jian Ji, Dachuan Zhang, Jin Ye, Yi Zheng, Jing Cui, Xiulan Sun
Summary: Mycotoxins can be converted into masked forms during plant metabolism or food processing, which, together with their prototypes, may cause mixture toxicity effects and have adverse effects on animal welfare and productivity. The structure elucidation of masked mycotoxins is challenging due to limitations in traditional analysis methods. To facilitate rapid identification, we developed MycotoxinDB, an online prediction tool based on reaction rules. Using MycotoxinDB, we successfully identified seven masked DONs from wheat samples. Given its widespread applications, MycotoxinDB is expected to become an indispensable tool in future mycotoxin research. MycotoxinDB is freely available at: http://www.mycotoxin-db.com/.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Engineering, Environmental
Shuangshou Wang, Yuwen Ding, Lu Zhang, Yingle Cheng, Ying Deng, Qin Jiang, Hongrui Gao, Jing Gu, Ganggang Yang, Lei Zhu, Tingxuan Yan, Qi Zhang, Jin Ye
Summary: A multi-mode visualization platform was developed for in-situ detection of food dyes by combining colorimetry, fluorometry, and smartphone-based digital image analysis. Water-dispersible quantum dots were used as nanoprobes for colorimetry and fluorometry. The platform showed fast and accurate detection capability and could be extended to other fields.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Hui Bao, Jin Ye, Xuyan Zhao, Yuan Zhang
Summary: A method of preparing nanocomposites for an all-solid potassium ion selective electrode using poly (3-octylthiophene-2,5-diyl) (POT) and carbon black (CB) as the transducer is proposed. The nanocomposites obtained, with POT as the dispersant, exhibit unique characteristics including high conductivity, high capacitance, and high stability. Characterization of the potassium ion selective electrode based on POT and CB was done using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and chronopotentiometry. Results showed a detection limit of potassium ions at 10(-6.2) M and a slope of 57.6 +/- 0.8 mV/decade. Water layer and anti-interference tests demonstrated high hydrophobicity of the electrode with a static contact angle of 139.7 degrees, and resistance to light, O-2, and CO2 interference.
Article
Food Science & Technology
Baoxia Ni, Jin Ye, Zhihong Xuan, Li Li, Xiangrui Wen, Zongwang Li, Hongmei Liu, Songxue Wang
Summary: A novel automated, high-throughput, and environmentally friendly pretreatment method is proposed, which combines immunomagnetic beads technology and dispersive liquid-liquid microextraction technology for the direct purification and concentration of zearalenone in corn oils. This method allows for batch pretreatment of samples without the use of organic reagents, resulting in minimal organic waste liquid. Coupled with UPLC-FLD, an effective and accurate quantitative detection method for zearalenone is established.
Article
Food Science & Technology
Xiaomin Han, Wenjing Xu, Luxinyi Wang, Ruina Zhang, Jin Ye, Jing Zhang, Jin Xu, Yu Wu
Summary: A total of 181 citrus-based products collected from China and abroad in 2021 were analyzed. The results showed that at least two or more Alternaria toxins were present in 83.4% of the analyzed products. Chinese-made products had higher levels of toxins compared to imported products. Solid and condensed liquid products, as well as tangerines, pummelos, and grapefruits, had higher concentrations of toxins compared to other citrus-based products.
Article
Chemistry, Multidisciplinary
Yansong Zhang, Zixin Zhang, Yihan Ding, Daojin Li, Shuangshou Wang
Summary: Clindamycin, a widely used compound in animal husbandry and fish husbandry, has been successfully imprinted onto magnetic nanoparticles for selective separation and enrichment in milk. The prepared clindamycin-imprinted magnetic nanoparticles demonstrated good specificity, high binding affinity, and high chemical stability, making them an ideal sorbent for clindamycin enrichment.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.