Article
Chemistry, Multidisciplinary
Jenna L. Payne, Zihang Deng, Andrew L. Flach, Jeffrey N. Johnston
Summary: In recent years, enantioselective halolactonization reactions have grown rapidly, but most are only effective in forming smaller rings (6,5,4-membered). The formation of highly selective seven-membered epsilon-lactones is rare and has never been achieved without conformational bias. This study describes the first highly enantioselective 7-exo-trig iodolactonizations of conformationally unbiased epsilon-unsaturated carboxylic acids, using a combination of a bifunctional BAM catalyst, I-2, and I(iii) reagent (PhI(OAc)(2):PIDA).
Article
Chemistry, Multidisciplinary
Selena J. Lockyer, Deepak Asthana, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, Grigore. A. Timco, Eric J. L. McInnes, Richard E. P. Winpenny
Summary: A synthetic strategy is used to prepare two distinct trimers of antiferromagnetically coupled {Cr7Ni} rings, showing substantial variation in magnetic interactions between spin centers.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Pornkanok Pongpamorn, Cholpisit Kiattisewee, Narongyot Kittipanukul, Juthamas Jaroensuk, Duangthip Trisrivirat, Somchart Maenpuen, Pimchai Chaiyen
Summary: Most esterification enzymes require minimization of water or activated substrates for activity, but this study found that carboxylic acid reductase (CAR) can catalyze esterification under aqueous conditions. By adding imidazole and other co-substrates, CAR can achieve high esterification yields for the synthesis of various compounds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Qi Yan, Ting Meng, Wendi Luo, Lei Sun, Qingdao Zeng, Haijun Xu
Summary: In this study, two new flavonol derivatives were synthesized and their self-assembly behaviors at the liquid/solid interface were investigated using scanning tunneling microscopy. The assembly of BDHF molecules with a pyridine derivative called BisPy successfully formed grid structures. Density functional theory calculations were conducted to understand the mechanism behind the assembly and co-assembly of flavonol derivatives and BisPy molecules.
Article
Chemistry, Multidisciplinary
Hui Luo, Jing Ren, Ying Sun, Yunlin Liu, Feng Zhou, Guoyue Shi, Jian Zhou
Summary: Carbon dioxide (CO2) is a highly abundant and sustainable C1 building block for chemical synthesis, but its low reactivity and stability restrict its transformation into value-added chemicals. Recent advancements in flow chemistry have enabled effective and continuous transformations of CO2, utilizing the advantages of continuous flow platforms. This article provides an update on the latest developments in this research area, highlighting the need for continuous CO2 transformation.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Xiaokang Li, Jianqiao Li, Chunyu Ma, Chen Chen, Siqi Zhang, Bin Tu, Wubiao Duan, Qingdao Zeng
Summary: In this study, the selective adsorption behaviors of the guest molecule COR in two hexamer host grids were investigated using STM, revealing different interactions between guest molecule COR and the host grids. Density functional theory calculations were performed to disclose the assembly mechanisms.
CHINESE CHEMICAL LETTERS
(2021)
Article
Water Resources
F. J. Castrillon-Munoz, J. J. Gibson, S. J. Birks
Summary: This study focuses on boreal lakes in the Athabasca Oil Sands Region (AOSR), Alberta, Canada. The study examines the hydrochemistry of 50 lakes that are considered to be acid sensitive and have been monitored by the Regional Aquatic Monitoring Program (RAMP) for the past two decades. The findings suggest that carbonate dissolution and organic matter uptake are the main processes controlling the increase in pH in these lakes. The study also provides insights into the influence of permafrost thaw and climate on the CO2 saturation and pH of the lakes.
JOURNAL OF HYDROLOGY-REGIONAL STUDIES
(2022)
Article
Multidisciplinary Sciences
Xu Qiu, Yueqian Sang, Hao Wu, Xiao-Song Xue, Zixi Yan, Yachong Wang, Zengrui Cheng, Xiaoyang Wang, Hui Tan, Song Song, Guisheng Zhang, Xiaohui Zhang, K. N. Houk, Ning Jiao
Summary: Synthetic chemistry is primarily focused on forming carbon-carbon bonds, but the development of methods for selective carbon-carbon bond cleavage is a significant challenge. These methods have potential applications in synthesis, coal liquefaction, petroleum cracking, polymer degradation, and biomass conversion.
Article
Chemistry, Organic
Lona Dutta, S. S. Ramasastry
Summary: This study describes a new method for the synthesis of 3HQs under neutral conditions, which also represents the first intramolecular oxyamination of α,β-ynones. The synthetic utility of this method is demonstrated by successfully synthesizing japonine, its analogs, and rare quinoline derivatives.
Review
Biochemistry & Molecular Biology
Andrea Vega, Ninoska Delgado, Michael Handford
Summary: The study discusses the harmful effects of heavy metals on plants and the counteracting effects of chelators, emphasizing the feasibility of exogenously adding organic compounds and analyzing the impact of different chelators on crop heavy metal tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Christopher J. Smedley
Summary: This article describes a novel method for synthesizing two unique sulfonyl fluoride cores using the highly reactive SASF center in addition reactions with DMSO and DMF. The stereoselectivity and excellent yields of the reactions are demonstrated.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
A. M. R. Ramirez, F. Mieres, F. Pineda, P. Grez, C. Heyser
Summary: Poly (indole-5-carboxylic acid) (5-PICA), Poly (indole-6-carboxylic acid) (6-PICA), and Poly (indole-7-carboxylic acid) (7-PICA) were electrochemically deposited onto AISI304 stainless steel. The morphology and structure of the polymer were characterized using IR spectroscopy and SEM. The corrosion protection performance was evaluated using LSV and EIS in sulfuric acid solution at different temperatures. The results showed that the morphology and branching structure of the polymer had a significant influence on its hydrophobicity and corrosion protection ability.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Food Science & Technology
Maria Ruiz-Rico, Felix Sancenon, Jose M. Barat
Summary: The limited solubility of chitosan at neutral and alkaline pH values restricts its use as a natural food preservative. However, its covalent immobilisation on inert supports can preserve its antimicrobial properties. Research shows that chitosan immobilisation through covalent urea bonding is the most suitable method, and chitosan-functionalised supports can effectively reduce microbial contamination in apple juice.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Cyprien Muller, Filip Horky, Marie Vayer, Andrei Golushko, David Leboeuf, Joseph Moran
Summary: This paper describes a new variant of the oxa-Pictet-Spengler reaction using epoxide as a starting material, which greatly expands the scope and rate of the reaction. By using hexafluoroisopropanol as a solvent, the electrophile scope of the reaction includes ketone analogues, aliphatic aldehydes, and phenylacetyl aldehydes, and the nucleophile scope includes moderately electronically deactivated and highly substituted beta-phenylethanols. In addition, the products can be further modified in the same system by subsequent ring-opening, reductions, and intra- and intermolecular Friedel-Crafts reactions. Finally, the synthesis of drug analogues demonstrates the pharmacological relevance of the isochroman motif.
Article
Biotechnology & Applied Microbiology
Malik Jan, Sheng-Jie Yue, Ru-Xiang Deng, Yan-Fang Nie, Hong-Yan Zhang, Xiang-Rui Hao, Wei Wang, Hong-Bo Hu, Xue-Hong Zhang
Summary: Filamentous fungi are considered robust microorganisms for the biotransformation of natural products in green chemistry. In this study, a new fungus strain Aspergillus sclerotiorum was isolated, which efficiently converts phenazine-1-carboxylic acid (PCA) into 3-hydroxy-phenazine 1-carboxylic acid (3-OH-PCA). An effective whole cells biotransformation system using optimal conditions and carbon sources was designed. The results showed promising potential for using filamentous fungi in large-scale biocatalysis of phenazine and efficient production of 3-OH-PCA.
FERMENTATION-BASEL
(2023)
Article
Chemistry, Inorganic & Nuclear
William D. Jobbins, Bono van IJzendoorn, Inigo J. Vitorica-Yrezabal, George F. S. Whitehead, Meera Mehta
Summary: The solution-state molecular chemistry of heptapnictogen clusters has not been well established. We investigated the heteroallene capture ability of heavy element derivatives of tetrel functionalized heptapnictogen clusters towards isocyanates and CO2. The experimental results showed that these clusters could capture isocyanates through their tetrel-pnictogen bonds, with different preferences for coordinating with nitrogen or oxygen atoms. This study also used density functional theory to explore the heteroallene insertion at these clusters.
DALTON TRANSACTIONS
(2023)
Article
Physics, Applied
Gabriele Clemente, Massimo Moret, Andres Granados del Aguila, Muhammad Hussain, Zdenek Sofer, Jiayuan Zhou, Xue Liu, Marco Fanciulli, Fabrizio Moro
Summary: In this study, the electron spin resonance (ESR) properties of a van der Waals bulk CrBr3 single crystal were investigated. Angular- and temperature-dependent experiments were conducted in the range of the critical temperature for ferromagnetic order. The results revealed a strong uniaxial magnetic anisotropy constant and the occurrence of long wavelength spin fluctuations. The findings have implications for the potential application of CrBr3 in perpendicular magnetic tunneling junctions.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Paula Escamilla, Lucia Bartella, Sergio Sanz-Navarro, Rita Maria Percoco, Leonardo Di Donna, Mario Prejano, Tiziana Marino, Jesus Ferrando-Soria, Donatella Armentano, Antonio Leyva-Perez, Emilio Pardo
Summary: Beta-lactam antibiotics are commonly used for treating bacterial infections, but their efficacy is limited due to the emergence of resistant bacteria with beta-lactamase enzymes. This study introduces a novel Zn-based metal-organic framework (MOF) that can mimic the catalytic activity of beta-lactamases. The MOF degrades the four-membered beta-lactam ring of amoxicillin, which expands the number of MOFs capable of mimicking enzymatic processes.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Cristina Negro, Sergio Sanz-Navarro, Antonio Leyva-Perez, Donatella Armentano, Jesu Ferrando-Soria, Emilio Pardo
Summary: Understanding the host-guest chemistry in MOFs has great potential to develop novel porous materials with improved performances in fields such as heterogeneous catalysis. In this study, a family of three isoreticular MOFs derived from amino acids were synthesized and their catalytic activities in hemiketalization reactions were investigated. The results showed that a multivariate MOF prepared using equal percentages of amino acids exhibited the most efficient catalytic conversions. The good catalytic performance was attributed to the intrinsic heterogeneity of the multivariate MOF.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jie Qu, Amr Elgendy, Rongsheng Cai, Mark A. Buckingham, Athanasios A. Papaderakis, Hugo de Latour, Kerry Hazeldine, George F. S. Whitehead, Firoz Alam, Charles T. Smith, David J. Binks, Alex Walton, Jonathan M. Skelton, Robert A. W. Dryfe, Sarah J. Haigh, David J. Lewis
Summary: In this study, a low-temperature and rapid approach was used to synthesize a high-entropy metal disulfide (MoWReMnCr)S-2. The resulting nanosheets showed a homogeneous distribution of metals and exhibited excellent hydrogen evolution electrocatalytic activity.
Article
Chemistry, Multidisciplinary
Luis Martinez-Crespo, Inigo J. Vitorica-Yrezabal, George F. S. Whitehead, Simon J. Webb
Summary: Relaying conformational change over several nanometers is crucial in allosterically regulated proteins. Scientists have successfully replicated this mechanism using nanometer-sized molecules that can reversibly switch between defined shapes in response to signaling molecules. The study demonstrated that a 1.8 nm long rigid rod molecule can serve as a switchable multi-squaramide hydrogen-bond relay, with each relay adopting different orientations based on proton signals and undergoing reversible changes. Additionally, a chemical fuel acted as a dissipative signal, causing the relay to return to its original orientation when consumed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Alexander C. Brannan, Elvie F. P. Beaumont, Nguyen Le Phuoc, George F. S. Whitehead, Mikko Linnolahti, Alexander S. Romanov
Summary: Organic TADF material 4BGIPN, based on benzoguanidine donor, shows impressive electronic properties and potential for the third generation of OLEDs. It emits yellow-green light with fast radiative rate and high photoluminescence quantum yield. With its stable highest occupied molecular orbital and lowest unoccupied molecular orbital, 4BGIPN is suitable for application as the electron transport layer or TADF class III emitter in OLEDs.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Selena J. Lockyer, Deepak Asthana, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, Grigore. A. Timco, Eric J. L. McInnes, Richard E. P. Winpenny
Summary: A synthetic strategy is used to prepare two distinct trimers of antiferromagnetically coupled {Cr7Ni} rings, showing substantial variation in magnetic interactions between spin centers.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Rajeh Alotaibi, Amy Booth, Edmund Little, Adam Brookfield, Amritroop Achari, Selena J. Lockyer, Grigore A. Timco, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, Nicholas F. Chilton, Rahul R. Nair, David Collison, Richard E. P. Winpenny
Summary: We synthesized and characterized a series of heterometallic rings using alkylammonium or imidazolium cations as templates. The structure of these rings can be controlled by the template and the coordination geometry preference of each metal, resulting in rings with eight, nine, ten, twelve, and fourteen metals. The compounds were analyzed using various techniques, including X-ray diffraction, elemental analysis, magnetometry, and EPR measurements. The magnetic measurements showed antiferromagnetic exchange coupling between the metal centers, while the EPR spectroscopy revealed different ground and excited states for different ring structures. These findings provide insights into the transferability of magnetic parameters among related compounds.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Tom S. Bennett, Selina Nawaz, Selena J. Lockyer, Deepak Asthana, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, Grigore A. Timco, Neil A. Burton, Richard E. P. Winpenny, Eric J. L. McInnes
Summary: This study reports the synthesis and structural characterization of four [7]rotaxanes formed by coordinating hybrid inorganic-organic [2]rotaxanes to a central {Ni12} core. X-ray single crystal diffraction shows the formation of [7]rotaxanes with different conformations in the crystal. Small angle X-ray scattering and molecular dynamic simulations confirm the stability of the large molecules in solution and reveal different conformers than those found in the crystal. Pulsed EPR spectroscopy demonstrates a slight reduction in phase memory times for the {Cr7Ni} rings, which are proposed as qubits, in the presence of the {Ni12} cage.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Cristina Bilanin, Paula Escamilla, Jesus Ferrando-Soria, Antonio Leyva-Perez, Donatella Armentano, Emilio Pardo
Summary: Host-guest chemistry within metal-organic frameworks (MOFs) offers great potential for the selective synthesis of industrially relevant products and represents a powerful alternative to current heterogeneous catalysts.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Bono van IJzendoorn, Jessica B. M. Whittingham, George F. S. Whitehead, Nikolas Kaltsoyannis, Meera Mehta
Summary: In this study, the boron functionalized [P7] cluster was applied in organic transformations, including dearomatized reduction of pyridines and hydroboration of imines and nitriles, leading to the synthesis of amine compounds. The catalyst exhibited high stability and could be recycled multiple times without loss in performance. The mechanism of the pyridine reduction was investigated experimentally and computationally. This work demonstrates the potential of boron functionalized phosphorus Zintl clusters as transition metal-free catalysts for nitrogen-containing substrates.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Bono van IJzendoorn, Jessica B. M. Whittingham, George F. S. Whitehead, Nikolas Kaltsoyannis, Meera Mehta
Summary: This study demonstrates that boron functionalized phosphorus Zintl cluster can serve as a catalyst for the reduction of nitrogen containing substrates. The catalyst showed high stability and could be recycled multiple times without loss in performance.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.
