期刊
CHEMICAL SCIENCE
卷 5, 期 9, 页码 3425-3431出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc00888j
关键词
-
资金
- National Science Foundation [ECCS 1231967, CBET 1139057]
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1231967] Funding Source: National Science Foundation
Experimental study of the charge transport properties associated with structural variations due to a change in the ionic environment will provide essential physical information in determining the nature of DNA molecules. This work reports an experimental study of the change in electronic transport properties induced by the conformational transition of a poly d(GC)(4) DNA. By gradually increasing the concentration of MgCl2 in the buffer solution from 0 M to 4 M, the conductance of the single DNA molecule decreased by two orders of magnitude. Circular dichroism (CD) measurements confirmed that a B to Z conformational transition caused the reduction in conductance. Using a stretch-hold mode scanning probe microscopy break junction (SPMBJ) technique, this B-Z transition process was monitored and a transition trend tine was successfully achieved from conductance measurements alone. The transition midpoint occurred at a MgCl2 concentration of 0.93 M for this DNA sequence. This method provides a general toot to study transitions of molecular properties associated with conductance differences.
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