期刊
CHEMICAL SCIENCE
卷 5, 期 11, 页码 4333-4338出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc01136h
关键词
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资金
- National Institutes of Health [R01-GM086258, U19-AI109673, RC4-GM096347, F32-GM108415]
- German National Academy of Sciences Leopoldina
- Divisions of Chemistry (CHE) and Materials Research (DMR)
- National Science Foundation [NSF/CHE-1346572]
- U.S. DOE [DE-AC02-06CH11357]
- FAS Division of Science, Research Computing Group at Harvard University
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1346572] Funding Source: National Science Foundation
- Villum Fonden [00010101] Funding Source: researchfish
We report a preliminary functional and complete structural characterization of a highly unusual geldanamycin analog, natalamycin A, that was isolated from Streptomyces strain M56 recovered from a South African nest of Macrotermes natalensis termites. Bioassay-guided fractionation based on antifungal activity led to the isolation of natalamycin A, and a combination of NMR spectroscopy and X-ray crystallographic analysis, including highly-accurate quantum-chemical NMR calculations on the largest and most conformationally-flexible system to date, revealed natalamycin A's three-dimensional solid-and solution-state structure. This structure along with the structures of related compounds isolated from the same source suggest a geldanamycin-like biosynthetic pathway with unusual post-PKS modifications.
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