期刊
CHEMICAL SCIENCE
卷 3, 期 5, 页码 1582-1588出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc01031c
关键词
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资金
- University Grants Council of Hong Kong [AoE/P-03-08]
- City University of Hong Kong [9667047, 9610020]
Eight new nitridoosmium(VI) complexes with the general formula [Os-VI(N)Cl-3(Hazole)(2)] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.
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