期刊
CHEMICAL SCIENCE
卷 2, 期 6, 页码 1003-1010出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0sc00647e
关键词
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资金
- NIH
- NSF
- National Key Scientific Program of China [2011CB911000]
- China National Grand Program on Key Infectious Disease [2009ZX10004-312]
- National Natural Science Foundation [20627005, 2060204]
As an alternative to antibodies, aptamers have shown promising applications in diagnostics and therapeutics. However, different from antibodies, the chemical nature of nucleic acids allows easy synthesis and modification of aptamers. As a result, there are various feasible ways to engineer aptamers with extended bioavailability (e. g., stability and binding affinity in complex environments), regulating ability, and multi-functional properties. In this review, recent advances in rational design and novel functionalization of aptamers, especially DNA aptamers, is described. The broad spectrum of ways for aptamer engineering and applications is paving the way for the future evolution of bioanalytical and biomedical developments.
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