期刊
CHEMICAL SCIENCE
卷 2, 期 8, 页码 1568-1572出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1sc00221j
关键词
-
资金
- National Science Foundation [CHE-0848224]
- National Institute of Health [GM49551]
- German Academic Exchange Service DAAD
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM049551] Funding Source: NIH RePORTER
Cysteine plays a number of important functional and structural roles in nature, often in the realm of catalysis. Herein, we present an example of a cysteine-promoted Rauhut-Currier reaction for a potentially biomimetic synthesis of Sch-642305 and related analogs. In this key step of the synthesis we discuss interesting new discoveries and the importance of substrate-catalyst recognition, as well as cysteine's structural features. Also, we investigate the activity of Sch-642305 and four analogs in HIV-infected T-cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据