Article
Chemistry, Multidisciplinary
Miaoxia Liu, Gerardo Salinas, Jing Yu, Antoine Cornet, Haidong Li, Alexander Kuhn, Neso Sojic
Summary: Multimodal imaging is a powerful approach that integrates multiple optical modalities in a single device, with potential applications in various fields. In this study, we developed wireless multimodal light-emitting chemical systems by coupling two light sources based on different physical principles. The results provide a novel alternative for designing autonomous hybrid systems with multimodal and multicolor optical readouts for complex bio-chemical systems.
Article
Chemistry, Multidisciplinary
Miaoxia Liu, Gerardo Salinas, Jing Yu, Antoine Cornet, Haidong Li, Alexander Kuhn, Neso Sojic
Summary: In this study, we developed a wireless multimodal light-emitting chemical device by combining two light sources based on different physical principles. This device integrates optical imaging and electrochemical reactions, providing a novel approach for complex bio-chemical systems.
Review
Biochemistry & Molecular Biology
Eleni Kyriakou, Gkikas Magiorkinis
Summary: In humans, retroviruses, including human endogenous retroviruses (HERVs) and exogenous retroviruses (HTLV and HIV), play complex roles in symbiosis and disease. This review explores the interactions between these groups, the influence of exogenous retrovirus infection on HERV expression, the impact of HERVs on the pathogenicity of HTLV and HIV, and the potential antiviral protection provided by HERVs.
TRENDS IN MICROBIOLOGY
(2023)
Article
Immunology
Ying Yin, Xiao-zhao Liu, Ximiao He, Li-quan Zhou
Summary: The study suggests that coronavirus infections can lead to increased retrotransposon expression, potentially causing genome instability and more severe symptoms, especially in cancer patients and the elderly. Additionally, the interaction between coronaviruses and retrotransposons may result in viral fragment invasion of the human genome, leading to more severe disease outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Food Science & Technology
Pengfei Gong, Ruoyu Shi, Jiali Tang, Jiaying Wang, Qiaoqiao Luo, Jia'ao Zhang, Xiaochun Ruan, Chengtao Wang, Wei Chen
Summary: In this study, the supplementation of exogenous ectoine effectively increased the production of Monascus pigments (MPs) and monacolin K (MK), while reducing citrinin (CTN) levels in Monascus purpureus. Moreover, the endogenous ectoine biosynthesis in Monascus showed comparable effects to exogenous addition, enhancing the stability of MPs. These findings propose an innovative strategy to improve the production and stability of bioactive compounds, and reduce CTN levels, advancing the Monascus industry.
Article
Multidisciplinary Sciences
N. Wang, G. Pugliese, M. Carrito, C. Moura, P. Vasconcelos, N. Cera, M. Li, P. Nobre, J. R. Georgiadis, J. K. Schubert, J. Williams
Summary: The chemical composition of exhaled breath was examined for volatile organic compound (VOC) indicators of sexual arousal in human beings. Both genders showed decreased levels of CO2 and isoprene in the breath during sexual arousal, while some males exhibited significant increases in indole, phenol, and cresol.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Giuseppe Ferrandino, Federico Ricciardi, Antonio Murgia, Iris Banda, Menisha Manhota, Yusuf Ahmed, Kelly Sweeney, Louise Nicholson-Scott, Lucinda McConville, Olga Gandelman, Max Allsworth, Billy Boyle, Agnieszka Smolinska, Carmen A. Ginesta Frings, Jorge Contreras, Claudia Asenjo-Lobos, Viviana Barrientos, Nataly Clavo, Angela Novoa, Amy Riviotta, Melissa Jerez, Luis Mendez
Summary: This study investigated a novel approach to cirrhosis detection based on dynamic breath testing. The researchers found that there was a significant increase in limonene breath levels in patients with cirrhosis, and this increase was correlated with the severity of the disease. Dynamic limonene breath testing enhances diagnostic performance for cirrhosis and has the potential to monitor therapeutic interventions.
Article
Hematology
Jesse I. Mobbs, Katrina A. Black, Michelle Tran, Wessel A. C. Burger, Hariprasad Venugopal, Theodore R. Holman, Michael Holinstat, David M. Thal, Alisa Glukhova
Summary: This study used single-particle cryo-electron microscopy to determine high-resolution structures of human 12-LOX, revealing its multiple oligomeric states and small molecule binding. The findings provide important insights into the assembly, catalytic mechanism, and drug development targeting the 12-LOX enzyme.
Article
Medicine, Research & Experimental
Elisabetta Panza, Ivana Bello, Martina Smimmo, Vincenzo Brancaleone, Emma Mitidieri, Mariarosaria Bucci, Giuseppe Cirino, Raffaella Sorrentino, Roberta d'Emmanuele di Villa Bianca
Summary: The impairment of the H2S pathway involving CSE and CBS-derived hydrogen sulfide is observed in urothelial carcinoma. Thus, targeting the H2S signaling pathway could be a novel therapeutic strategy for this type of cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Multidisciplinary
Antonio Shegani, Steven Kealey, Federico Luzi, Filippo Basagni, Joana do Mar Machado, Sevban Dogan Ekici, Alessandra Ferocino, Antony D. Gee, Salvatore Bongarzone
Summary: The presence of PET centers at major hospitals and the improvement of PET scanner sensitivity have increased interest in PET tracer development using carbon-11. Methodological improvements and automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 has provided important information on their biochemistry and in vivo behavior.
Article
Biophysics
Alexander Farnum, Michael Parnas, Ehsanul Hoque Apu, Elyssa Cox, Noel Lefevre, Christopher H. Contag, Debajit Saha
Summary: There is evidence that cancer alters cellular metabolic processes, which can be detected through the volatile organic compound compositions emitted by cancer cells. This study developed an insect olfactory neural circuit-based VOC sensor to detect oral cancer cells. The results showed that this method can effectively distinguish different oral cancer cell lines from each other and non-cancer cell lines.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Pharmacology & Pharmacy
Hua Fan, Qianqian Bai, Yang Yang, Xiaofei Shi, Ganqin Du, Junqiang Yan, Jian Shi, Dongmei Wang
Summary: Aberrant innate immunity in the brain is associated with several CNS disorders. Microglia, the main immune cells in the CNS, and endogenous antioxidant systems play important roles in regulating neuroinflammation. Sulfur-containing compounds that modulate these systems may have therapeutic potential for neuroinflammation-related diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Jianlin Han, Lorand Kiss, Haibo Mei, Attila Mario Remete, Maja Ponikvar-Svet, Daniel Mark Sedgwick, Raquel Roman, Santos Fustero, Hiroki Moriwaki, Vadim A. Soloshonok
Summary: This comprehensive review focuses on the effects of fluoride ions and organofluorine compounds on human health and the environment, as well as related topics including the reasons for the advancement of fluorine-containing pharmaceuticals and agrochemicals, metabolism of fluorinated drugs, withdrawn fluorinated drugs, natural sources of fluorine compounds in the environment, sources of fluoride intake, and biomarkers of fluoride exposure.
Article
Engineering, Environmental
Hao Wang, Haimei Wang, Keliang Wang, Jianyin Xiong, Shaodan Huang, Jack M. Wolfson, Petros Koutrakis
Summary: This study develops a two-layer analytical model to characterize the VOC/SVOC dermal uptake process, and extends it to predict VOC emissions from two-layer building materials or furniture. The key transport parameters of chemicals in every skin or material layer are determined via a hybrid optimization method using data from experiments and literature. The association between the absorption amount of studied chemicals into blood and age is preliminarily investigated, and dermal uptake is found to contribute significantly to the total exposure of examined SVOCs.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Chemistry, Analytical
Qiwen Yu, Jing Chen, Wei Fu, Kanhar Ghulam Muhammad, Yi Li, Wenxin Liu, Linxin Xu, Hao Dong, Di Wang, Jun Liu, Yanli Lu, Xing Chen
Summary: Lung cancer, with its high morbidity and mortality, has been studied for decades. Traditional methods for diagnosis are invasive and expensive, hindering early screening and diagnosis. Smartphones integrated with powerful applications show great potential for improving the detection and monitoring of lung cancer markers in various medical settings.
Article
Chemistry, Analytical
Joachim D. Pleil, Matthew A. Stiegel
ANALYTICAL CHEMISTRY
(2013)
Article
Biotechnology & Applied Microbiology
Sixin S. Lu, Jon R. Sobus, Gerd Sallsten, Maria Albin, Joachim D. Pleil, Anders Gudmundsson, Michael C. Madden, Bo Strandberg, Aneta Wierzbicka, Stephen M. Rappaport
Article
Biochemistry & Molecular Biology
Joachim D. Pleil, Jon R. Sobus, Paul R. Sheppard, Gary Ridenour, Mark L. Witten
CHEMICO-BIOLOGICAL INTERACTIONS
(2012)
Editorial Material
Environmental Sciences
Joachim D. Pleil, Benjamin C. Blount, Suramya Waidyanatha, Martin Harper
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2012)
Article
Environmental Sciences
Joachim D. Pleil, Jon R. Sobus
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2013)
Review
Environmental Sciences
Yu-Mei Tan, Jon Sobus, Daniel Chang, Rogelio Tornero-Velez, Michael Goldsmith, Joachim Pleil, Curtis Dary
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2012)
Review
Environmental Sciences
Joachim D. Pleil
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2012)
Review
Medicine, General & Internal
Andrew J. Ghio, Jon R. Sobus, Joachim D. Pleil, Michael C. Madden
SWISS MEDICAL WEEKLY
(2012)
Article
Biochemical Research Methods
S. Ghimenti, F. Di Francesco, M. Onor, M. A. Stiegel, M. G. Trivella, C. Comite, N. Catania, R. Fuoco, J. D. Pleil
JOURNAL OF BREATH RESEARCH
(2013)
Editorial Material
Biochemical Research Methods
Terence H. Risby, Joachim D. Pleil
JOURNAL OF BREATH RESEARCH
(2013)
Editorial Material
Biochemical Research Methods
J. D. Beauchamp, J. D. Pleil
JOURNAL OF BREATH RESEARCH
(2013)
Editorial Material
Biochemical Research Methods
Joachim D. Pleil
JOURNAL OF BREATH RESEARCH
(2013)
Article
Biochemical Research Methods
Joachim D. Pleil, Wolfram Miekisch, Matthew A. Stiegel, Jonathan Beauchamp
JOURNAL OF BREATH RESEARCH
(2014)
Article
Public, Environmental & Occupational Health
Kenneth W. Fent, Judith Eisenberg, John Snawder, Deborah Sammons, Joachim D. Pleil, Matthew A. Stiegel, Charles Mueller, Gavin P. Horn, James Dalton
ANNALS OF OCCUPATIONAL HYGIENE
(2014)