Article
Critical Care Medicine
Sharina Kort, Marjolein Brusse-Keizer, Hugo Schouwink, Emanuel Citgez, Frans H. de Jongh, Jan W. G. van Putten, Ben van den Borne, Elisabeth A. Kastelijn, Daiana Stolz, Milou Schuurbiers, Michel M. van den Heuvel, Wouter H. van Geffen, Job van der Palen
Summary: This study developed and validated a prediction model to distinguish patients with non-small cell lung cancer from non-lung cancer subjects using exhaled breath analysis. It also investigated the impact of adding clinical variables to improve the diagnosis. The results showed that combining exhaled breath data and clinical variables can effectively differentiate lung cancer patients from non-lung cancer subjects in a noninvasive manner, paving the way for the implementation of exhaled breath analysis in lung cancer diagnosis.
Article
Food Science & Technology
Xiaoguang Dong, Libing Gao, Haijun Zhang, Jing Wang, Kai Qiu, Guanghai Qi, Shugeng Wu
Summary: The study evaluated the sensory qualities of eggs from three commercial laying breeder strains, finding significant differences in smell profiles and successfully discriminating the breeds based on electronic nose data.
Article
Chemistry, Multidisciplinary
Jing Li, Ami Hannon, George Yu, Luke A. Idziak, Adwait Sahasrabhojanee, Prasanthi Govindarajan, Yvonne A. Maldonado, Khoa Ngo, John P. Abdou, Nghia Mai, Antonio J. Ricco
Summary: We improved an existing, spaceflight-proven, robust electronic nose (E-Nose) that mimics aspects of mammalian olfaction to rapidly screen for COVID-19 infection. The E-Nose detects volatile organic compounds (VOCs) in exhaled breath by measuring the pattern of sensor responses from an array of nanosensors. Preliminary clinical testing demonstrated a 79% correct identification rate between COVID-19-positive and COVID-19-negative individuals.
Article
Medicine, General & Internal
Valentina Sas, Paraschiva Chereches-Panta, Diana Borcau, Cristina-Nicoleta Schnell, Edita-Gabriela Ichim, Daniela Iacob, Alina-Petronela Coblisan, Tudor Drugan, Sorin-Claudiu Man
Summary: Electronic nose (e-nose) is a new technology used to identify volatile organic compounds (VOC) in breath air. It can adequately identify airway inflammation in asthma patients. In this study, the e-nose was able to discriminate pediatric patients with asthma from controls, but the accuracy was lower in the external validation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Carmen Bax, Stefano Robbiani, Emanuela Zannin, Laura Capelli, Christian Ratti, Simone Bonetti, Luca Novelli, Federico Raimondi, Fabiano Di Marco, Raffaele L. Dellaca
Summary: A novel sampling system was developed for analyzing exhaled breath in respiratory failure patients, showing good tolerance and successful discrimination by support vector machine between respiratory failure patients and controls.
Article
Chemistry, Analytical
Ariana Lammers, Anne H. Neerincx, Susanne J. H. Vijverberg, Cristina Longo, Nicole A. H. Janssen, A. John F. Boere, Paul Brinkman, Flemming R. Cassee, Anke H. Maitland van der Zee
Summary: This study explored the effects of short-term exposure to air pollution on the exhaled breath profiles of healthy adults, finding that high levels of air pollution may influence breath composition, although the impact may be minimal for regular daily exposures.
Review
Chemistry, Analytical
Chuntae Kim, Iruthayapandi Selestin Raja, Jong-Min Lee, Jong Ho Lee, Moon Sung Kang, Seok Hyun Lee, Jin-Woo Oh, Dong-Wook Han
Summary: This review discusses the importance of artificial olfactory systems in fields such as healthcare, along with the trend and prospects of using these systems for disease diagnosis. Monitoring health status and early disease diagnosis are crucial in modern healthcare, with the potential to increase survival rates and reduce treatment costs. The article introduces promising technologies for real-time monitoring of health conditions and early disease diagnosis through analysis of exhaled human breath.
Article
Medicine, General & Internal
Lisa Goudman, Julie Jansen, Nieke Vets, Ann De Smedt, Maarten Moens
Summary: This study evaluated whether an electronic nose could differentiate between chronic pain patients with Spinal Cord Stimulation (SCS) activated versus deactivated, finding that exhaled breath could not effectively distinguish between the two states in patients with Failed Back Surgery Syndrome (FBSS). The findings suggest that exhaled breath cannot be used as an additional marker of the effect of neuromodulation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Li Yang, Guanghao Zheng, Yaoqian Cao, Chuizhou Meng, Yuhang Li, Huadong Ji, Xue Chen, Guangyu Niu, Jiayi Yan, Ye Xue, Huanyu Cheng
Summary: This study presents the design and demonstration of a moisture-resistant, stretchable NOx gas sensor based on laser-induced graphene (LIG). The gas sensor exhibits a large response, an ultralow detection limit, fast response/recovery, and excellent selectivity. It can be stretched by 30% and has been demonstrated to monitor the personal local environment and analyze human breath samples for disease diagnostics.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Biochemical Research Methods
D. Gallart-Mateu, P. Dualde, C. Coscolla, J. M. Soriano, S. Garrigues, M. de la Guardia
Summary: The exposure to smoking related products was evaluated through the analysis of urine samples of smokers and vapers. The study identified and quantified various biomarkers and their metabolites in the urine samples. The findings suggest that traditional smoking practice is a major source of carcinogenic chemicals compared to substitutive practices, although there are still potential harm in alternative practices.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Hsiao-Yu Yang, Wan-Chin Chen, Rodger-Chen Tsai
Summary: The review analyzed 44 eligible studies and found that sensor-based breath tests have a sensitivity of 90.0%, specificity of 88.4%, and an area under the curve of 0.93. Standardized reporting of diagnostic accuracy and accuracy in a test set are essential for the use of electronic noses in hospitals.
Article
Chemistry, Analytical
Yolande Christelle Ketchanji Mougang, Laurent-Mireille Endale Mangamba, Rosamaria Capuano, Fausto Ciccacci, Alexandro Catini, Roberto Paolesse, Hugo Bertrand Mbatchou Ngahane, Leonardo Palombi, Corrado Di Natale
Summary: Tuberculosis is a common cause of death in many countries, and the current diagnostic method of smear microscopy has a low true positive rate. Analyzing exhaled VOCs using sensors has been proposed as a promising alternative for disease diagnosis. Testing an electronic nose based on sensor technology in a Cameroon hospital showed promising results for the diagnosis of pulmonary TB.
Article
Chemistry, Analytical
Bei Liu, Huiqing Yu, Xiaoping Zeng, Dan Zhang, Juan Gong, Ling Tian, Junhui Qian, Leilei Zhao, Shuya Zhang, Ran Liu
Summary: This research aimed to differentiate lung cancer patients by analyzing VOCs through an E-nose platform, with 87 subjects enrolled for data collection. A sparse group feature selection method was applied to improve classification performance significantly, while statistical analysis showed that age and smoking habit had no significant influences on classification results.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Roberta Anzivino, Pasqua Irene Sciancalepore, Silvano Dragonieri, Vitaliano Nicola Quaranta, Paolo Petrone, Domenico Petrone, Nicola Quaranta, Giovanna Elisiana Carpagnano
Summary: The aim of this study was to assess the ability of a polymer-based e-nose to accurately distinguish head and neck cancer patients, healthy controls, and patients with allergic rhinitis. The results showed that the e-nose was able to differentiate between these three groups, suggesting its potential as a diagnostic tool for head and neck cancer. It is a user-friendly, fast, non-invasive, and cost-effective technology.
Article
Chemistry, Analytical
M. Hassani-Marand, N. Fahimi-Kashani, M. R. Hormozi-Nezhad
Summary: A high-performance colorimetric artificial tongue was proposed for the multiplex detection of catecholamine neurotransmitters (CNs). Different aggregation behaviors of gold nanoparticles in the presence of CNs under various buffering conditions generate unique fingerprint response patterns. The utilization of machine learning algorithms enables the classification and quantification of CNs in various samples.
ANALYTICAL METHODS
(2023)