Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anqi Xu, Xiao Jie, Yan Xiu, Hongcheng Shi
Summary: Metastasis of papillary thyroid cancer to nasopharynx is rare and can mimic nasopharyngeal carcinoma.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Caner Civan, Emine Goknur Isik, Seyfullah Karadogan, Yasemin Sanli, Serkan Kuyumcu
Summary: This article presents a case of a 62-year-old male with progressive left-sided papillary renal cell carcinoma. Ga-68-FAPI-04 and F-18-FDG PET/CT imaging revealed variable FAP expression in all metastatic lesions, including lymph nodes, bone, and thyroid. This case highlights the potential of FAP-targeted imaging for diagnostic and theranostic use in papillary renal cell carcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Makoto Taninokuchi Tomassoni, Arrigo Cattabriga, Caterina Gaudiano, Federica Ciccarese, Beniamino Corcioni, Lorenzo Bianchi, Riccardo Schiavina, Eugenio Brunocilla, Rita Golfieri
Summary: This case report presents a rare bladder paraganglioma with unusual onset and typical PET/CT characteristics, which aids in the recognition of paragangliomas.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Arnoldo Piccardo, Francesco Fiz, Giorgio Treglia, Gianluca Bottoni, Pierpaolo Trimboli
Summary: F-18-FES PET/CT can help overcome the reduced sensitivity of F-18-FDG PET/CT in ER+ breast cancer. When comparing the diagnostic accuracy of the two methods, lesion-based analysis and patients-based analysis should be considered. The results showed that F-18-FES may be preferred for restaging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Vahid Roshanravan, Ramin Sadeghi, Seyed Rasoul Zakavi, Nasim Norouzbeigi, Atena Aghaee
Summary: Ga-68-FAPI is a novel and versatile radiotracer with potential use in cancer and inflammatory conditions. This report presents a case of chronic sialadenitis diagnosed using Ga-68-FAPI PET/CT imaging in a patient with papillary thyroid carcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Richard Black, Jelle Barentsz, David Howell, David G. Bostwick, Stephen B. Strum
Summary: The accuracy of cancer diagnosis using FDG PET-CT is often inaccurate due to subjective interpretation. A new method of interpretation, combining multiple factors to optimize SUV, was compared with conventional non-normalized SUV. The optimized method showed superior accuracy in diagnosing cancer in different patient groups, including mediastinal/hilar lymph node metastases, extrathoracic lymph node metastases, and liver metastases. The optimized SUVmax interpretation improved the diagnostic accuracy of FDG PET-CT for cancer compared to conventional SUVmax interpretation.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Jiaying Zhang, Shaobo Yao, Weibing Miao
Summary: This is a case of metastatic papillary thyroid cancer in a patient previously treated with multiple therapies. CT scan of the chest revealed pleural thickening and effusion, and pleural biopsy confirmed the metastatic lesion. Ga-68-fibroblast activation protein inhibitor PET/CT can be helpful in identifying the metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hao Fu, Jing Wu, Jingxiong Huang, Long Sun, Hua Wu, Wei Guo, Sihuang Qiu, Haojun Chen
Summary: This study evaluated the clinical utility of Ga-68-FAPI PET/CT for detecting metastatic differentiated thyroid cancer (DTC) and compared it with F-18-FDG PET/CT. The results showed that Ga-68-FAPI PET/CT had a higher sensitivity than F-18-FDG PET/CT for depicting metastatic DTC, especially in lymph nodes and pulmonary metastases.
Article
Endocrinology & Metabolism
Chantal A. Lebbink, Lisa H. de Vries, Inne H. M. Borel Rinkes, Arthur J. A. T. Braat, Rachel S. van Leeuwaarde, Lutske Lodewijk, Mark J. C. van Treijen, Menno R. Vriens, Gerlof D. Valk, Hanneke M. van Santen, Bart de Keizer
Summary: This study demonstrates the potential usefulness of FDG PET/CT in detecting persistent or recurrent DTC in patients with low detectable thyroglobulin levels. However, a negative result on FDG PET/CT does not exclude the possibility of DTC, necessitating further investigations.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yuhua Yang, Lisha Liu, Juyi Lin, Shengcai Huang
Summary: A 46-year-old woman presented with menorrhagia, abdominal distension, and neck mass, which led to the diagnosis of uterine follicular dendritic cell sarcoma. After 6 cycles of CHOP-like chemotherapy, complete resolution was observed on F-18-FDG PET/CT scan.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yang Lu
Summary: A 76-year-old man with metastatic papillary thyroid cancer and prostate cancer underwent surgeries and androgen deprivation treatment. PET scans revealed metastases in the mediastinal nodule and L5 vertebra. The biopsy confirmed the L5 lesion was from prostate cancer. The patient responded well to radiation therapy for the L5 lesion.
CLINICAL NUCLEAR MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Daniel J. Hughes, Manil Subesinghe, Benjamin Taylor, Andrea Bille, James Spicer, Sophie Papa, Vicky Goh, Gary J. R. Cook
Summary: Immunotherapy has greatly improved the treatment of many cancers, but patient selection and the accuracy of predictive biomarkers remain challenges. Molecular imaging shows potential in assessing treatment response, guiding personalized therapy, and monitoring immune-related toxicities.
Article
Endocrinology & Metabolism
Shu-qi Wu, Fang Feng, Ren-jian Zou, Hong-liang Fu, Jia-wei Sun, Xi-ze Jia, Ya-fu Yin, Hui Wang
Summary: The study found that more PTC patients exhibited depression and anxiety after LT4 withdrawal for 4 weeks, highlighting the need for increased attention to these patients. Brain glucose metabolism analysis indicated that LT4 withdrawal may induce abnormal regional cerebral glucose metabolism. The study attempts to explain the possible mechanism of mood disorders related to transient hypothyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ian Alberts, Jan-Niklas Huenermund, Christos Sachpekidis, Clemens Mingels, Viktor Fech, Karl Peter Bohn, Axel Rominger, Ali Afshar-Oromieh
Summary: Digital PET/CT demonstrated a higher detection rate for pathological lesions compared with analogue PET/CT, with an improved true-positive rate and without increased diagnostic uncertainty, rate of non-specific lesions, or reduced interrater reliability.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Madhusudan A. Savaikar, Timothy Whitehead, Sudipta Roy, Lori Strong, Nicole Fettig, Tina Prmeau, Jingqin Luo, Shunqiang Li, Richard L. Wahl, Kooresh Shoghi
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Richard L. Wahl, Panithaya Chareonthaitawee, Bonnie Clarke, Alexander Drzezga, Liza Lindenberg, Arman Rahmim, James Thackeray, Gary A. Ulaner, Wolfgang Weber, Katherine Zukotynski, John Sunderland
Summary: The Society of Nuclear Medicine and Molecular Imaging's Value Initiative focuses on demonstrating the value of molecular imaging and molecularly targeted radiopharmaceutical therapy, with the research and discovery domain being crucial for advancing diagnostic and therapeutic nuclear medicine. Leaders have identified 5 broad areas of opportunity for future growth and clinical impact in this field.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Arda Konik, Joseph A. O'Donoghue, Richard L. Wahl, Michael M. Graham, Annick D. Van den Abbeele
Summary: Theranostics is a precision medicine discipline that integrates diagnostic nuclear medicine imaging with radionuclide therapy to provide personalized treatment for cancer patients. By using quantitative nuclear medicine imaging, accurate therapeutic plans can be developed based on the in-vivo distribution of radioactivity concentration within tumors and normal organs/tissues.
SEMINARS IN RADIATION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David H. Ballard, Udayabhanu Jammalamadaka, Kathleen W. Meacham, Mark J. Hoegger, Broc A. Burke, Jason A. Morris, Alexander R. Scott, Zachary O'Connor, Connie Gan, Jesse Hu, Karthik Tappa, Richard L. Wahl, Pamela K. Woodard
Summary: The study aimed to design a 3D-printed alternative N95 respirator that passed OSHA-certified quantitative fit testing. Two out of ten prototypes designed with flexible materials passed fit testing, showing potential for use after comprehensive evaluation.
ACADEMIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Diane S. Abou, Amanda Fears, Lucy Summer, Mark Longtine, Nadia Benabdallah, Ryan C. Riddle, David Ulmert, Jeff M. Michalski, Richard L. Wahl, Denise Chesner, Michele Doucet, Nicholas C. Zachos, Brian W. Simons, Daniel L. J. Thorek
Summary: The study investigates the role of enteric ion channels in improving the uptake of Ra-223 and reducing toxicity. In vivo experiments showed that amiloride can enhance bone uptake and inhibit tumor growth when combined with other agents. This combination therapy has the potential to improve outcomes for bone-metastatic cancer patients while maintaining tolerability.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Richard L. Wahl, Vasken Dilsizian, Christopher J. Palestro
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin A. Lodge, Lilja B. Solnes, Muhammad A. Chaudhry, Richard L. Wahl
Summary: A study found that pre-dosing with unlabeled octreotide can decrease radiotracer uptake in normal liver and spleen, but has minimal impact on uptake in tumor and other organs. This suggests that discontinuing somatostatin analog therapy before PET/CT with Ga-68-DOTATOC may not be necessary, potentially simplifying patient protocols. Further research is needed to explore the implications of this approach in different clinical settings.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark J. Hoegger, Mark S. Longtine, Kyuhwan Shim, Richard L. Wahl
Summary: This study compared survival and optical imaging characteristics of mice strains with varied coat colors harboring luciferase-expressing disseminated lymphoma, finding that mouse pelt color and imaging aspect are critical considerations for quantifying bioluminescent tumor signal. The R2G2 mouse strain may be useful for preclinical targeted therapy studies.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ashwin Singh Parihar, Lisa R. Schmidt, Farrokh Dehdashti, Richard L. Wahl
Summary: The aim of this study was to evaluate the detection rate of incidental second primary neoplasms in patients with prostate cancer on F-18-fluciclovine PET/CT. The results showed that 9.1% of patients had findings suggestive of a second neoplasm, with renal cell carcinoma being the most common (45.5%).
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Richard L. Wahl, Eric C. Frey, Heather A. Jacene, Brad S. Kahl, Steven Piantadosi, Jesus A. Bianco, Richard J. Hammes, Miah Jung, Wayne Kasecamp, Bin He, George Sgouros, Ian W. Flinn, Lode J. Swinnen
Summary: The study evaluates the feasibility of SPECT-CT/planar organ dosimetry-based radiation dose escalation radioimmunotherapy in patients with recurrent non-Hodgkin's lymphoma. The approach was patient-specific and showed efficient tumor response rates, variability in liver dosimetry, and feasibility of exceeding FDA-approved activity. The study supports the feasibility of patient-specific dose escalation in the treatment of NHL with stem cell transplant.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark J. Hoegger, Anup S. Shetty, Darcy R. Denner, Jennifer E. Gould, Richard L. Wahl, Constantine A. Raptis, David H. Ballard
Summary: The COVID-19 pandemic had a broad impact on radiology trainees and their training programs, affecting aspects such as resident wellness, imaging opinions, and opinions regarding exam delays. Most institutions reported positive cases of COVID-19, with residents generally favoring laboratory testing over imaging and some using COVID-19 terminology when encountering chest CT findings suggestive of viral pneumonia in symptomatic patients.
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anne M. Smith, Nancy A. Obuchowski, Norman L. Foster, Gregory Klein, P. David Mozley, Adriaan A. Lammertsma, Richard L. Wahl, John J. Sunderland, Jean-Luc Vanderheyden, Tammie L. S. Benzinger, Paul E. Kinahan, Dean F. Wong, Eric S. Perlman, Satoshi Minoshima, Dawn Matthews
Summary: Standardized approach in acquiring amyloid PET images increases their value as disease and drug response biomarkers. The Quantitative Imaging Biomarkers Alliance amyloid PET biomarker committee developed and validated a profile to characterize and reduce the variability of SUVRs, increasing statistical power for these assessments.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Prabhakar Shantha Rajiah, Maria Jose Sarda, Ravi Ashwath, Harold Goerne
Article
Multidisciplinary Sciences
Thomas F. Heston, John Y. Jiang
Summary: This study aimed to determine whether chest X-ray imaging could achieve acceptable diagnostic accuracy in patients with a low body mass index (BMI). A retrospective study of 50 patients with acute, nontraumatic cardiopulmonary complaints who underwent chest X-ray and CT scans showed that even in patients with a low BMI, chest X-ray had significantly lower diagnostic accuracy compared to CT.
Review
Radiology, Nuclear Medicine & Medical Imaging
Donna M. Peehl, Cristian T. Badea, Thomas L. Chenevert, Heike E. Daldrup-Link, Li Ding, Lacey E. Dobrolecki, A. McGarry Houghton, Paul E. Kinahan, John Kurhanewicz, Michael T. Lewis, Shunqiang Li, Gary D. Luker, Cynthia X. Ma, H. Charles Manning, Yvonne M. Mowery, Peter J. O'Dwyer, Robia G. Pautler, Mark A. Rosen, Raheleh Roudi, Brian D. Ross, Kooresh I. Shoghi, Renuka Sriram, Moshe Talpaz, Richard L. Wahl, Rong Zhou
Summary: The availability of high-fidelity animal models has increased, allowing for preclinical studies relevant to cancer research. Co-clinical trials conducted on animal models that mirror patients' tumors have seen increased opportunities. However, quantitative imaging in co-clinical trials still needs optimization.